Karakikes, Ioannis

Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes: Insights Into Molecular, Cellular, and Functional Phenotypes

Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 478

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

Lee, J., Termglinchan, V., Diecke, S., Itzhaki, I., Lam, C. K., Garg, P., Lau, E., Greenhaw, M., Seeger, T., Wu, H., et al. (2019) · Nature

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 222

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 184

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Matsa, E., Burridge, P. W., Yu, K.-H., Ahrens, J. H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J. M., et al. (2016) · Cell stem cell

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 164

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

Chen, A., Lieu, D. K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., et al. (2011) · Advanced Materials

Cellular Mechanics and InteractionsAdvanced Materials and Mechanics

Cited by 122

Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration

Nakayama, K. H., Quarta, M., Paine, P., Alcazar, C., Karakikes, I., Garcia, V., Abilez, O. J., Calvo, N. S., Simmons, C. S., Rando, T. A., et al. (2019) · Communications Biology

Tissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical Applications

Cited by 113

A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells

Weng, Z., Kong, C.-W., Ren, L., Karakikes, I., Geng, L., He, J., Chow, M. Z. Y., Mok, C. F., Chan, H. Y. S., Webb, S. E., et al. (2014) · Stem Cells and Development

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 109

Telomere shortening is a hallmark of genetic cardiomyopathies

Chang, A. C. Y., Chang, A. C. H., Kirillova, A., Sasagawa, K., Su, W., Weber, G., Lin, J., Termglinchan, V., Karakikes, I., Seeger, T., et al. (2018) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCardiomyopathy and Myosin Studies

Cited by 91

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Stillitano, F., Turnbull, I. C., Karakikes, I., Nonnenmacher, M., Backeris, P., Hulot, J.-S., Kranias, E. G., Hajjar, R. J., & Costa, K. D. (2016) · European Heart Journal

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 77

Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation

Beeri, R., Chaput, M., Guerrero, J. L., Kawase, Y., Yosefy, C., Abedat, S., Karakikes, I., Morel, C., Tisosky, A., Sullivan, S., et al. (2010) · Circulation: Heart Failure

Cardiac Fibrosis and RemodelingCardiac Structural Anomalies and Repair

Cited by 69

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias

Wang, J., Chen, A., Lieu, D. K., Karakikes, I., Chen, G., Keung, W., Chan, C. W., Hajjar, R. J., Costa, K. D., Khine, M., et al. (2013) · Biomaterials

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

Cited by 69

iPSC Modeling of RBM20-Deficient DCM Identifies Upregulation of RBM20 as a Therapeutic Strategy

Briganti, F., Sun, H., Wei, W., Wu, J., Zhu, C., Liss, M., Karakikes, I., Rego, S., Cipriano, A., Snyder, M., et al. (2020) · Cell Reports

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 68

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs

Chen, G., Li, S., Karakikes, I., Ren, L., Zi-Ying Chow, M., Chopra, A., Keung, W., Yan, B., Chan, C. W. Y., Costa, K. D., et al. (2015) · Circulation: Arrhythmia and Electrophysiology

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 38

Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy

Zhang, J., Zanella, F., Ellis, M. W., Bradford, W. H., Gutierrez-Lara, E. J., Wang, T.-M., Fujita, K., Duron, C., Karakikes, I., Lyon, R. C., et al. (2026) · Circulation: Heart Failure

Cardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmias

Cited by 5