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Cited by 122Cellular Mechanics and InteractionsAdvanced Materials and MechanicsTissue Engineering and Regenerative Medicine

Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

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Chen, Aaron, Lieu, Deborah K., Freschauf, Lauren, Lew, Valerie, Sharma, Himanshu, Wang, Jiaxian, Nguyen, Diep, Karakikes, Ioannis +6 more·2011·Advanced Materials
DOI 10.1002/adma.201103463
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Abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated.

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  • Prior studies have arranged hPSC-derived ventricular cardiomyocytes as monolayers and patches for electrophysiology and for surgical implantation.

    “Although hPSC-vCMs have been organized as monolayers and patches for electrophysiological assessment [6–8] and even surgical engraftment [9–11]”

    From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [6]

    The paper’s Experimental Section reports optical mapping of action-potential propagation in aligned hESC-derived cardiomyocyte monolayers, supporting the electrophysiology portion. It does not identify those cells specifically as ventricular cardiomyocytes or report patches or surgical implantation. The citing sentence assigns surgical engraftment to a separate citation group [9–11]. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 32

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Authors
Chen, A., Lieu, D. K., Freschauf, L., Lew, V., Sharma, H., Wang, J., Nguyen, D., Karakikes, I., Hajjar, R. J., Gopinathan, A., Botvinick, E., Fowlkes, C. C., Li, R. A., & Khine, M.
Affiliations
  • University of California, Irvine (US)
  • University of California, Davis (US)
  • University of Hong Kong (HK)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
  • Li, Ronald A.
  • Khine, Michelle
ORCID
Venue
Advanced Materials
Publisher
Wiley
Published
2011-11-08
Volume
23
Issue
48
Pages
5785-5791
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
DOI
10.1002/adma.201103463
OpenAlex
W2004994313
Cited by
122
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 6 · 2017: 9 · 2016: 14 · 2015: 15 · 2014: 14 · 2013: 11 · 2012: 8
FWCI
5.21
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • California Institute for Regenerative Medicine
  • Edwards Lifesciences
  • National Institutes of Health (DP2OD007283)
  • Defense Advanced Research Projects Agency (N66001-1-4003)
  • University of California, Irvine
  • Advanced Research Projects Agency
  • National Heart, Lung, and Blood Institute (R01HL119046, R01HL093183, R01 HL-72857, R01HL072857)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
biomimetic substrates, plasma treatment, cell alignment, human embryonic stem cells, cardiomyocytes, cardiac differentiation, cell culture substrates
MeSH terms
Action Potentials, Animals, Cell Differentiation, Cells, Cultured, Equipment Design, Flow Cytometry, Humans, Materials Testing, Myocardium, Stem Cells, Surface Properties, Myocytes, Cardiac, Biomimetics, Mice, Rats, Embryonic Stem Cells

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