Hedley, Ann

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Frezza, C., Zheng, L., Folger, O., Rajagopalan, K. N., MacKenzie, E. D., Jerby, L., Micaroni, M., Chaneton, B., Adam, J., Hedley, A., et al. (2011) · Nature

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Fumarate induces redox-dependent senescence by modifying glutathione metabolism

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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

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Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancer

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

Sakamaki, J.-I., Wilkinson, S., Hahn, M., Tasdemir, N., O’Prey, J., Clark, W., Hedley, A., Nixon, C., Long, J. S., New, M., et al. (2017) · Molecular Cell

Autophagy in Disease and TherapyProtein Degradation and Inhibitors

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Repression of the Type I Interferon Pathway Underlies MYC- and KRAS-Dependent Evasion of NK and B Cells in Pancreatic Ductal Adenocarcinoma

Muthalagu, N., Monteverde, T., Raffo-Iraolagoitia, X., Wiesheu, R., Whyte, D., Hedley, A., Laing, S., Kruspig, B., Upstill-Goddard, R., Shaw, R., et al. (2020) · Cancer Discovery

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The ERBB network facilitates KRAS-driven lung tumorigenesis

Kruspig, B., Monteverde, T., Neidler, S., Hock, A., Kerr, E., Nixon, C., Clark, W., Hedley, A., Laing, S., Coffelt, S. B., et al. (2018) · Science Translational Medicine

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

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Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

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Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

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Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

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