Fallon, Padraic G.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

Cited by 1,885

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology

Inflammatory Bowel DiseaseMicroscopic Colitis

Cited by 407

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

Hams, E., Armstrong, M. E., Barlow, J. L., Saunders, S. P., Schwartz, C., Cooke, G., Fahy, R. J., Crotty, T. B., Hirani, N., Flynn, R. J., et al. (2014) · Proceedings of the National Academy of Sciences

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisIL-33, ST2, and ILC Pathways

Cited by 376

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development

Townsend, M. J., Fallon, P. G., Matthews, D. J., Smith, P., Jolin, H. E., & McKenzie, A. N. J. (2000) · Immunity

Asthma and respiratory diseasesMast cells and histamine

Cited by 328

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Scholz, C. C., Cavadas, M. A. S., Tambuwala, M. M., Hams, E., Rodríguez, J., Kriegsheim, A. V., Cotter, P., Bruning, U., Fallon, P. G., Cheong, A., et al. (2013) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 186

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

Saunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M., Oliphant, C. J., Núñez, G., McManus, R., et al. (2016) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesAsthma and respiratory diseases

Cited by 160

Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity

Smith, P., Fallon, R. E., Mangan, N. E., Walsh, C. M., Saraiva, M., Sayers, J. R., McKenzie, A. N. J., Alcami, A., & Fallon, P. G. (2005) · The Journal of Experimental Medicine

Parasites and Host InteractionsParasitic Diseases Research and Treatment

Cited by 160

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

Hams, E., Saunders, S. P., Cummins, E. P., O'Connor, A., Tambuwala, M. T., Gallagher, W. M., Byrne, A., Campos-Torres, A., Moynagh, P. M., Jobin, C., et al. (2011) · Shock

Sepsis Diagnosis and TreatmentImmune Response and Inflammation

Cited by 106