IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development
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Interleukin-9 is a cytokine produced by Th2 cells and is a candidate gene for asthma and atopy. We have generated IL-9-deficient mice to delineate the specific roles of IL-9 in Th2 responses. Using a pulmonary granuloma model, we have demonstrated a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge. In contrast, eosinophilia and granuloma formation were not affected. IL-9 was not required for T cell development or differentiation, the generation of naive or antigen-driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis. Thus, deletion of IL-9 manifests as a highly defined phenotype in Th2 responses modulating mucus production and mast cell proliferation.
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IL-9 promotes mucus production from lung epithelial cells and pulmonary mastocytosis.
“IL-9 promotes mucus production from lung epithelial cells and pulmonary mastocytosis14–17.”
From The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation (2010) · cites this paper as [17]
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Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
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Self-citationRepositioning TH cell polarization from single cytokines to complex help
Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., & Becher, B. (2021) · Nature Immunology · doi:10.1038/s41590-021-01009-w · Cited by 171 · see citing works
IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis
Gerlach, K., McKenzie, A. N., Neurath, M. F., & Weigmann, B. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.983777 · Cited by 83 · see citing works
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- Authors
- Townsend, M. J., Fallon, P. G., Matthews, D. J., Smith, P., Jolin, H. E., & McKenzie, A. N. J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- University of Cambridge (GB)
- Corresponding author
- McKenzie, Andrew N.J
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 13
- Issue
- 4
- Pages
- 573-583
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1991018824
- Cited by
- 328
- References
- 2
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 3 · 2023: 8 · 2022: 13 · 2021: 7 · 2020: 10 · 2019: 5 · 2018: 11 · 2017: 22 · 2016: 12 · 2015: 20 · 2014: 15 · 2013: 11 · 2012: 16
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- IL-9, Th2 immune response, goblet cell hyperplasia, mucus production, pulmonary granuloma, eosinophilia, T cell development, antibody response, Nippostrongylus brasiliensis, asthma, atopy
- MeSH terms
- Animals, Antibody Formation, Cell Differentiation, Hyperplasia, Immunoglobulins, Lung, Mastocytosis, Mice, Inbred C57BL, Nippostrongylus, T-Lymphocytes, Granuloma, Respiratory Tract, Cytokines, Interleukin-9, Strongylida Infections, Mice, Knockout, Gene Targeting, Th1 Cells, Th2 Cells, Epitopes, T-Lymphocyte, Goblet Cells, Mice
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