Mancias, Joseph D.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature

Autophagy in Disease and TherapyIron Metabolism and Disorders

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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Yamamoto, K., Venida, A., Yano, J., Biancur, D. E., Kakiuchi, M., Gupta, S., Sohn, A. S. W., Mukhopadhyay, S., Lin, E. Y., Parker, S. J., et al. (2020) · Nature

Autophagy in Disease and TherapyCancer Immunotherapy and Biomarkers

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Plasticity in binding confers selectivity in ligand-induced protein degradation

Nowak, R. P., DeAngelo, S. L., Buckley, D., He, Z., Donovan, K. A., An, J., Safaee, N., Jedrychowski, M. P., Ponthier, C. M., Ishoey, M., et al. (2018) · Nature Chemical Biology

Protein Degradation and InhibitorsChemical Synthesis and Analysis

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Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

Mancias, J. D., Pontano Vaites, L., Nissim, S., Biancur, D. E., Kim, A. J., Wang, X., Liu, Y., Goessling, W., Kimmelman, A. C., & Harper, J. W. (2015) · eLife

Autophagy in Disease and TherapyIron Metabolism and Disorders

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The role of NCOA4-mediated ferritinophagy in health and disease

Santana-Codina, N., & Mancias, J. D. (2018) · Pharmaceuticals

Autophagy in Disease and TherapyIron Metabolism and Disorders

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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Biancur, D. E., Paulo, J. A., Małachowska, B., Quiles Del Rey, M., Sousa, C. M., Wang, X., Sohn, A. S. W., Chu, G. C., Gygi, S. P., Harper, J. W., et al. (2017) · Nature Communications

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

Nabet, B., Ferguson, F. M., Seong, B. K. A., Kuljanin, M., Leggett, A. L., Mohardt, M. L., Robichaud, A., Conway, A. S., Buckley, D. L., Mancias, J. D., et al. (2020) · Nature Communications

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

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Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

Dilly, J., Hoffman, M. T., Abbassi, L., Li, Z., Paradiso, F., Parent, B. D., Hennessey, C. J., Jordan, A. C., Morgado, M., Dasgupta, S., et al. (2024) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

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Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Kuljanin, M., Mitchell, D. C., Schweppe, D. K., Gikandi, A. S., Nusinow, D. P., Bulloch, N. J., Vinogradova, E. V., Wilson, D. L., Kool, E. T., Mancias, J. D., et al. (2021) · Nature Biotechnology

Click Chemistry and ApplicationsAdvanced Proteomics Techniques and Applications

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Neurons release serine to support mRNA translation in pancreatic cancer

Banh, R. S., Biancur, D. E., Yamamoto, K., Sohn, A. S. W., Walters, B., Kuljanin, M., Gikandi, A., Wang, H., Mancias, J. D., Schneider, R. J., et al. (2020) · Cell

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

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NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

Quiles del Rey, M., & Mancias, J. D. (2019) · Frontiers in Neuroscience

Autophagy in Disease and TherapyIron Metabolism and Disorders

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Mechanisms of Selective Autophagy in Normal Physiology and Cancer

Mancias, J. D., & Kimmelman, A. C. (2016) · Journal of Molecular Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

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Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer

Parker, S. J., Amendola, C. R., Hollinshead, K. E. R., Yu, Q., Yamamoto, K., Encarnación-Rosado, J., Rose, R. E., LaRue, M. M., Sohn, A. S. W., Biancur, D. E., et al. (2020) · Cancer Discovery

Amino Acid Enzymes and MetabolismPancreatic and Hepatic Oncology Research

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Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review

de Geus, S. W. L., Eskander, M. F., Kasumova, G. G., Ng, S. C., Kent, T. S., Mancias, J. D., Callery, M. P., Mahadevan, A., & Tseng, J. F. (2017) · Cancer

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Coordinated transcriptional and catabolic programs support iron-dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer

Ravichandran, M., Hu, J., Cai, C., Ward, N. P., Venida, A., Foakes, C., Kuljanin, M., Yang, A., Hennessey, C. J., Yang, Y., et al. (2022) · Cancer Discovery

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

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Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

Santana-Codina, N., Chandhoke, A. S., Yu, Q., Małachowska, B., Kuljanin, M., Gikandi, A., Stańczak, M., Gableske, S., Jedrychowski, M. P., Scott, D. A., et al. (2020) · Cell Reports

Protein Kinase Regulation and GTPase SignalingAdvanced Proteomics Techniques and Applications

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Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., et al. (2022) · eLife

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

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