Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review
Open accessAbstract
BACKGROUND: The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer. METHODS: The National Cancer Data Base was queried for unresected patients who received chemotherapy for nonmetastatic pancreatic adenocarcinoma between 2004 and 2012. Four treatment groups were identified: chemotherapy alone, chemotherapy combined with external‐beam radiotherapy (EBRT), chemotherapy combined with intensity‐modulated radiotherapy (IMRT), and chemotherapy combined with SBRT. Propensity score models predicting the odds of receiving SBRT were created to control for potential selection bias, and patients were matched by propensity scores. The survival analysis was performed with the Kaplan‐Meier method. RESULTS: A total of 14,331 patients met the inclusion criteria. Chemotherapy alone was delivered to 5464 patients (38.1%); 6418 (44.8%), 322 (2.3%), and 2127 (14.8%) received chemotherapy along with EBRT, IMRT, and SBRT, respectively. The unadjusted median survival before matching was 9.9, 10.9, 12.0, and 13.9 months for patients treated with chemotherapy, EBRT, IMRT, and SBRT, respectively. In separate matched analyses, SBRT remained superior to chemotherapy alone (log‐rank P < .0001) and EBRT (log‐rank P = .0180). After matching, survival did not differ between patients receiving IMRT and patients receiving SBRT (log‐rank P = .0492). CONCLUSIONS: SBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158–4167. © 2017 American Cancer Society.
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Stereotactic body radiotherapy (SBRT) has significantly better outcomes than chemotherapy alone or in combination with conventional external-beam radiotherapy (EBRT).
“It has been proven that SBRT has significantly better outcomes than chemotherapy alone or in combination with conventional external-beam radiotherapy (EBRT) 244.”
From Artificial intelligence in pancreatic cancer (2022) · cites this paper as [244]
Cites
TNM Classification of Malignant Tumours
Hermanek, P., & Sobin, L. H. (1987) · Springer eBooks · doi:10.1007/978-3-642-82982-6 · Cited by 16,073 · see citing works
Austin, P. C. (2011) · Multivariate Behavioral Research · doi:10.1080/00273171.2011.568786 · Cited by 12,242 · see citing works
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452 · see citing works
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Conroy, T., Desseigne, F., Ychou, M., Bouché, O., Guimbaud, R., Bécouarn, Y., Adenis, A., Raoul, J.-L., Gourgou-Bourgade, S., de la Fouchardière, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011923 · Cited by 7,810 · see citing works
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., Seay, T., Tjulandin, S. A., Ma, W. W., Saleh, M. N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304369 · Cited by 6,712 · see citing works
TNM Classification of Malignant Tumors
Carter, D. (1998) · The American Journal of Surgical Pathology · doi:10.1097/00000478-199810000-00016 · Cited by 6,354 · see citing works
Neoptolemos, J. P., Palmer, D. H., Ghaneh, P., Psarelli, E. E., Valle, J. W., Halloran, C. M., Faluyi, O. O., O'Reilly, D. A., Cunningham, D., Wadsley, J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)32409-6 · Cited by 1,942 · see citing works
The National Cancer Data Base: A Powerful Initiative to Improve Cancer Care in the United States
Bilimoria, K. Y., Stewart, A. K., Winchester, D. P., & Ko, C. Y. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9747-3 · Cited by 1,853 · see citing works
International Classification of Diseases for Oncology
Trott, P. A. (1977) · Journal of Clinical Pathology · doi:10.1136/jcp.30.8.782-c · Cited by 1,688 · see citing works
Hammel, P. R., Huguet, F., Laethem, J. V., Goldstein, D., Glimelius, B. L. G., Artru, P., Borbath, I., Bouché, O., Shannon, J., André, T., et al. (2016) · JAMA · doi:10.1001/jama.2016.4324 · Cited by 1,092 · see citing works
Loehrer, P. J., Feng, Y., Cardenes, H. R., Wagner, L. I., Brell, J. M., Cella, D. F., Flynn, P. J., Ramanathan, R. K., Crane, C. H., Alberts, S. R., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.8904 · Cited by 831 · see citing works
Chauffert, B., Mornex, F., Bonnetain, F., Rougier, P. R., Mariette, C., Bouché, O., Bosset, J.-F., Aparicio, T., Mineur, L., Azzedine, A., et al. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn281 · Cited by 696 · see citing works
Gastrointestinal Tumor Study Group (1988) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/80.10.751 · Cited by 576 · see citing works
Pancreatic Adenocarcinoma, Version 2.2014
Tempero, M. A., Malafa, M. P., Behrman, S. W., Benson, A. B., Casper, E. S., Chiorean, E. G., Chung, V. M., Cohen, S. J., Czito, B. G., Engebretson, A., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0106 · Cited by 464 · see citing works
Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer
Koong, A. C., Le, Q., Ho, A., Fong, B. T., Fisher, G. A., Cho-Phan, C. D., Ford, J., Poen, J. C., Gibbs, I. C., Mehta, V. K., et al. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2003.11.004 · Cited by 445 · see citing works
Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas
Chang, D. T., Schellenberg, D. D., Shen, J., Kim, J., Goodman, K. A., Fisher, G. A., Ford, J. M., Desser, T. S., Quon, A. S. W., & Koong, A. C. (2009) · Cancer · doi:10.1002/cncr.24059 · Cited by 378 · see citing works
Schellenberg, D. D., Kim, J., Christman-Skieller, C., Chun, C. L., Columbo, L. A., Ford, J. M., Fisher, G. A., Kunz, P. L., Dam, J. V., Quon, A. S. W., et al. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2010.05.006 · Cited by 253 · see citing works
Overcoming drug resistance in pancreatic cancer
Long, J., Zhang, Y., Yu, X., Yang, J., LeBrun, D. G., Chen, C., Yao, Q. C., & Li, M. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.566216 · Cited by 239 · see citing works
Sultana, A., Smith, C. T., Cunningham, D., Starling, N., Tait, D., Neoptolemos, J. P., & Ghaneh, P. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603719 · Cited by 235 · see citing works
Nuttall, M., van der Meulen, J., & Emberton, M. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.07.015 · Cited by 219 · see citing works
Gastrointestinal Tumor Study Group (1985) · Cancer · doi:10.1002/1097-0142(19851201)56:11 · Cited by 172 · see citing works
Stereotactic Body Radiotherapy in the Treatment of Advanced Adenocarcinoma of the Pancreas
Rwigema, J.-C. M., Parikh, S. D., Heron, D. E., Howell, M., Zeh, H. J., Moser, A. J., Bahary, N., Quinn, A. E., & Burton, S. A. (2010) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3181d270b4 · Cited by 165 · see citing works
The Secret of Immortal Time Bias in Epidemiologic Studies
Shariff, S. Z., Cuerden, M. S., Jain, A. K., & Garg, A. X. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007121354 · Cited by 164 · see citing works
Moningi, S., Dholakia, A. S., Raman, S. P., Blackford, A. L., Cameron, J. L., Le, D. T., Jesus‐Acosta, A. D., Hacker‐Prietz, A., Rosati, L. M., Assadi, R. K., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-014-4274-5 · Cited by 163 · see citing works
Calonge, M. J., & Massagué, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33637 · Cited by 146 · see citing works
Gurka, M. K., Collins, S. P., Slack, R. S., Tse, G., Charabaty, A., Ley, L., Berzcel, L., Lei, S., Suy, S., Haddad, N., et al. (2013) · Radiation Oncology · doi:10.1186/1748-717x-8-44 · Cited by 125 · see citing works
Bittner, M.-I., Grosu, A., & Brunner, T. B. (2014) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2014.11.043 · Cited by 91 · see citing works
Gurka, M. K., Kim, C. M., He, A. R., Charabaty, A., Haddad, N., Turocy, J. M., Johnson, L. B., Jackson, P. G., Weiner, L. M., Marshall, J. L., et al. (2014) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000118 · Cited by 68 · see citing works
Locally Advanced Pancreatic Cancer: The Role of Definitive Chemoradiotherapy
Huguet, F., Mukherjee, S., & Javle, M. M. (2014) · Clinical Oncology · doi:10.1016/j.clon.2014.06.002 · Cited by 54 · see citing works
Swaminath, A., & Chu, W. (2015) · Canadian Urological Association Journal · doi:10.5489/cuaj.2900 · Cited by 29 · see citing works
Ambe, C. M., Fulp, W. J., Springett, G. M., Hoffe, S. E., & Mahipal, A. (2015) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-015-9734-z · Cited by 20 · see citing works
Surgery for Localized Pancreatic Cancer
Strohl, M. P., Raigani, S., Ammori, J. B., Hardacre, J. M., & Kim, J. A. (2015) · Pancreas · doi:10.1097/mpa.0000000000000511 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yang, X., Lu, Y., Hang, J., Zhang, J., Zhang, T., Huo, Y., Liu, J., Lai, S., Luo, D., Wang, L., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0111 · Cited by 278 · see citing works
Artificial intelligence in pancreatic cancer
Huang, B., Huang, H., Zhang, S., Zhang, D., Shi, Q., Liu, J., & Guo, J. (2022) · Theranostics · doi:10.7150/thno.77949 · Cited by 142 · see citing works
“It has been proven that SBRT has significantly better outcomes than chemotherapy alone or in combination with conventional external-beam radiotherapy (EBRT) [244].”
BackgroundLocally Advanced Pancreatic Cancer: A Review of Local Ablative Therapies
Ruarus, A. H., Vroomen, L. G. P. H., Puijk, R. S., Scheffer, H. J., & Meijerink, M. R. (2018) · Cancers · doi:10.3390/cancers10010016 · Cited by 87 · see citing works
Oar, A. J., Lee, M., Le, H. V., Hruby, G., Dalfsen, R., Pryor, D. I., Lee, D., Chu, J., Holloway, L. C., Briggs, A., et al. (2019) · Practical Radiation Oncology · doi:10.1016/j.prro.2019.07.018 · Cited by 70 · see citing works
Self-citationStereotactic body radiation therapy for locally advanced pancreatic cancer
Jung, J., Yoon, S. M., Park, J., Seo, D., Lee, S. S., Kim, M.-H., Lee, S. K., Park, D. H., Song, T. J., Yoo, C., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214970 · Cited by 70 · see citing works
Concurrent chemoradiotherapy using proton beams for unresectable locally advanced pancreatic cancer
Hiroshima, Y., Fukumitsu, N., Saito, T., Numajiri, H., Murofushi, K. N., Ohnishi, K., Nonaka, T., Ishikawa, H., Okumura, T., & Sakurai, H. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.03.012 · Cited by 56 · see citing works
Bouchart, C., Navez, J., Closset, J., Hendlisz, A., Gestel, D. V., Moretti, L., & Laethem, J. V. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920936093 · Cited by 43 · see citing works
An Interpretable Planning Bot for Pancreas Stereotactic Body Radiation Therapy
Zhang, J., Wang, C., Sheng, Y., Palta, M., Czito, B., Willett, C., Zhang, J., Jensen, P. J., Yin, F.-F., Wu, Q., et al. (2021) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2020.10.019 · Cited by 41 · see citing works
Demidov, V. V., Maeda, A., Sugita, M., Madge, V., Sadanand, S., Flueraru, C., & Vitkin, I. A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18635-w · Cited by 39 · see citing works
Janssen, Q. P., van Dam, J. L., Kivits, I. G., Besselink, M. G., van Eijck, C. H. J., Homs, M. Y. V., Nuyttens, J. J. M. E., Qi, H., van Santvoort, H. C., Wei, A. C.-C., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-10276-8 · Cited by 39 · see citing works
Janssen, Q. P., van Dam, J. L., Prakash, L. R., Doppenberg, D., Crane, C. H., van Eijck, C. H. J., Ellsworth, S. G., Jarnagin, W. R., O'Reilly, E. M., Paniccia, A., et al. (2022) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2022.7008 · Cited by 36 · see citing works
Metastatic renal cell carcinoma to the pancreas: Clinical features and treatment outcome
Shin, T. J., Song, C., Jeong, C. W., Kwak, C. H., Seo, S., Kang, M., Chung, J., Hong, S., Hwang, E. C., Park, J. Y., et al. (2020) · Journal of Surgical Oncology · doi:10.1002/jso.26251 · Cited by 36 · see citing works
Burkoň, P., Trna, J., Slavík, M., Němeček, R., Kazda, T., Pospíšil, P., Dastych, M., Eid, M., Novotný, I., Procházka, T., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10102480 · Cited by 33 · see citing works
Gutierrez, N. M. C., Clainche, T. L., Bulin, A., Leo, S., Kadri, M., Abdelhamid, A. G. A., Pujol‐Solé, N., Obaid, G., Hograindleur, M., Gardette, V., et al. (2024) · Advanced Materials · doi:10.1002/adma.202404605 · Cited by 33 · see citing works
Pancreatic cancer: treatment approaches and trends
Pereira, N. P., & Corrêa, J. R. (2018) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2018.13 · Cited by 33 · see citing works
Cui, J., Jiao, F., Li, Q., Wang, Z., Fu, D., Liang, J., Liang, H., Xia, T., Zhang, T., Zhang, Y., et al. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.08.006 · Cited by 32 · see citing works
Simoni, N., Micera, R., Paiella, S., Guariglia, S., Zivelonghi, E., Malleo, G., Rossi, G., Addari, L., Giuliani, T., Pollini, T., et al. (2020) · Clinical Oncology · doi:10.1016/j.clon.2020.06.019 · Cited by 28 · see citing works
Oar, A. J., Lee, M. A., Le, H. V., Wilson, K., Aiken, C., Chantrill, L. A., Simes, J. R., Nguyen, N. Q., Barbour, A. P., Samra, J. S., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08666-y · Cited by 28 · see citing works
Seufferlein, T. T. W., Mayerle, J. V., Böck, S., Brunner, T. B., Ettrich, T. J., Grenacher, L., Gress, T. M., Hackert, T., Heinemann, V., Kestler, A. M. R., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1856-7346 · Cited by 27 · see citing works
Slagowski, J. M., Colbert, L. E., Cazacu, I. M., Singh, B. S., Martin, R., Koay, E. J., Taniguchi, C. M., Koong, A. C., Bhutani, M. S., Herman, J. M., et al. (2020) · Practical Radiation Oncology · doi:10.1016/j.prro.2020.01.007 · Cited by 26 · see citing works
Committee of the Korean clinical practice guideline for pancreatic cancer and National Cancer Center, K. (2021) · Pancreatology · doi:10.1016/j.pan.2021.05.004 · Cited by 26 · see citing works
Ejlsmark, M. W., Bahij, R., Schytte, T., Hansen, C. R., Bertelsen, A. S., Mahmood, F., Mortensen, M. B., Detlefsen, S., Weber, B., Bernchou, U., et al. (2024) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2024.110347 · Cited by 25 · see citing works
Pancreatic cancer in young adults: changes, challenges, and solutions
Primavesi, F., Stättner, S., Schlick, K., Kiesslich, T., Mayr, C., Klieser, E., Urbas, R., & Neureiter, D. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s176700 · Cited by 24 · see citing works
ARCELLI, A., Buwenge, M., Macchia, G., Bertini, F., Guido, A., Deodato, F., Cilla, S., Scotti, V., Rosetto, M. E., Djan, I., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.3330 · Cited by 24 · see citing works
Gutierrez, N. M. C., Pujol‐Solé, N., Arifi, Q., Coll, J., Clainche, T. L., & Broekgaarden, M. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10064-0 · Cited by 24 · see citing works
Recent advances in the management of pancreatic adenocarcinoma
Karakaş, Y., Laçin, Ş., & Yalçın, Ş. (2017) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1403319 · Cited by 24 · see citing works
Neoadjuvant stereotactic body radiation therapy for nonmetastatic pancreatic adenocarcinoma
Jiang, W., Haque, W. M., Verma, V., Butler, E. B., & Teh, B. S. (2019) · Acta Oncologica · doi:10.1080/0284186x.2019.1631472 · Cited by 21 · see citing works
Niedzielski, J. S., Liu, Y., Ng, S. S. W., Martin, R., Perles, L. A., Beddar, S. A., Rebueno, N. C. S., Koay, E. J., Taniguchi, C. M., Holliday, E. B., et al. (2021) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2021.08.002 · Cited by 20 · see citing works
Self-citationManderlier, M., Navez, J., Hein, M., Engelholm, J.-L., Closset, J., Bali, M. A., Gestel, D. V., Moretti, L., Laethem, J. V., & Bouchart, C. (2022) · Cancers · doi:10.3390/cancers14235730 · Cited by 20 · see citing works
Hill, C., Rosati, L. M., Wang, H., Tsai, H., He, J. P., Hacker‐Prietz, A., Laheru, D. A., Zheng, L., Sehgal, S., Bernard, V., et al. (2022) · Practical Radiation Oncology · doi:10.1016/j.prro.2022.02.009 · Cited by 19 · see citing works
Mazzarotto, R., Simoni, N., Guariglia, S., Rossi, G., Micera, R., Robertis, R. D., Pierelli, A., Zivelonghi, E., Malleo, G., Paiella, S., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.600940 · Cited by 19 · see citing works
Demidov, V. V., Demidova, N., Pires, L., Demidova, O., Flueraru, C., Wilson, B. C., & Vitkin, I. A. (2021) · Biomedical Optics Express · doi:10.1364/boe.424045 · Cited by 19 · see citing works
Radiotherapy for Locally Advanced Pancreatic Adenocarcinoma—A Critical Review of Randomised Trials
Ejlsmark, M. W., Schytte, T., Bernchou, U., Bahij, R., Weber, B., Mortensen, M. B., & Pfeiffer, P. (2023) · Current Oncology · doi:10.3390/curroncol30070499 · Cited by 18 · see citing works
Dallavalle, S., Campagnoli, G., Pastena, P., Martinino, A., Schiliró, D., & Giovinazzo, F. (2024) · Medicina · doi:10.3390/medicina60071070 · Cited by 18 · see citing works
Wu, R., Su, Z., Le, Z., Pei, R., Ding, Y., Li, D., Zhu, S., Xu, L., Zhao, W., & Zhou, W. (2023) · Stem Cells International · doi:10.1155/2023/6510571 · Cited by 17 · see citing works
EUS-guided placement of fiducial markers for the treatment of pancreatic cancer
Coronel, E. S., Singh, B. S., Cazacu, I. M., Moningi, S., Romero, L. G., Taniguchi, C. M., Herman, J. M., & Bhutani, M. S. (2019) · VideoGIE · doi:10.1016/j.vgie.2019.05.007 · Cited by 17 · see citing works
Buwenge, M., ARCELLI, A., Cellini, F., Deodato, F., Macchia, G., Cilla, S., Galietta, E., Strigari, L., Malizia, C., Cammelli, S., et al. (2022) · Current Oncology · doi:10.3390/curroncol29040214 · Cited by 17 · see citing works
Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia
Slotman, B. J., Clark, M. A., Özyar, E., Kim, M., Itami, J., Tallet, A. R., Debus, J., Pfeffer, R., Gentile, P., Hama, Y., et al. (2022) · Radiation Oncology · doi:10.1186/s13014-022-02114-2 · Cited by 16 · see citing works
Chuong, M. D., Clark, M. A., Henke, L. E., Kishan, A. U., Portelance, L., Parikh, P. J., Bassetti, M. F., Nagar, H., Rosenberg, S. A., Mehta, M. P., et al. (2022) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2022.11.013 · Cited by 16 · see citing works
Enhanced CXCL12/CXCR4 signaling increases tumor progression in radiation‑resistant pancreatic cancer
Kato, T., Matsuo, Y., Ueda, G., Murase, H., Aoyama, Y., Omi, K., Hayashi, Y., Imafuji, H., Saito, K., Morimoto, M., et al. (2022) · Oncology Reports · doi:10.3892/or.2022.8279 · Cited by 14 · see citing works
Kim, S., & Shin, E. J. (2021) · Clinical Endoscopy · doi:10.5946/ce.2021.102 · Cited by 14 · see citing works
The Role of Radiation Therapy in the Older Patient
Dohm, A. E., Díaz, R., & Nanda, R. H. (2021) · Current Oncology Reports · doi:10.1007/s11912-020-01000-y · Cited by 13 · see citing works
Narita, Y., Katō, T., Takemasa, K., Sato, H., Ikeda, T., Harada, T., Oyama, S., & Murakami, M. (2021) · Journal of Applied Clinical Medical Physics · doi:10.1002/acm2.13429 · Cited by 13 · see citing works
Tang, L., Wu, J., Cai, S., Huang, Y.-X., Zhang, X.-Q., Fu, W., Zhuang, Q., & Li, J. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s187615 · Cited by 13 · see citing works
Uchinami, Y., Kanehira, T., Fujita, Y., Miyamoto, N., Yokokawa, K., Koizumi, F., Shido, M., Takahashi, S., Otsuka, M., Yasuda, K., et al. (2023) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2023.100576 · Cited by 12 · see citing works
FULBERT, C., Chaput, F., Stelse‐Masson, S., Henry, M., Chovelon, B., Bohic, S., Brückner, D., Garrevoet, J., Moriscot, C., Gallet, B., et al. (2024) · Small Science · doi:10.1002/smsc.202400041 · Cited by 11 · see citing works
Large database utilization in health outcomes research in pancreatic cancer: an update
Torgeson, A. M., Tao, R., Garrido‐Laguna, I., Willen, B. D., Le, A., & Lloyd, S. A. J. (2018) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2018.05.15 · Cited by 11 · see citing works
Doppenberg, D., Besselink, M. G., van Eijck, C. H. J., Intven, M., Koerkamp, B. G., Geert Kazemier, M., van Laarhoven, H. W. M., Meijerink, M. R., Molenaar, I. Q., Nuyttens, J. J. M. E., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10419-4 · Cited by 10 · see citing works
Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics
Zhang, S., Li, D., Liu, Y., Qin, C., Tong, L., & Xu, L. (2023) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100022 · Cited by 10 · see citing works
Pacella, G., Brunese, M. C., D’Imperio, E., Rotondo, M., Scacchi, A., Carbone, M., & Guerra, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12237380 · Cited by 10 · see citing works
Liu, S., Liu, Y., Yang, J., Santos, T. D., Yang, L., Li, M., Jiang, Q., & Ma, C. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101139 · Cited by 9 · see citing works
Shin, Y. S., Park, H. H., Park, J., Seo, D., Lee, S. S., Yoo, C., Kim, S., Yoon, S. M., Jung, J., Kim, M., et al. (2022) · Cancers · doi:10.3390/cancers14051166 · Cited by 9 · see citing works
Cao, B., Zhang, L., Wu, C.-C., Liu, X., Wang, Q., Tong, F., Yang, W., & Wang, J. (2023) · Cancers · doi:10.3390/cancers15082213 · Cited by 9 · see citing works
Global perspective on the genetic, epigenetic, and transcriptomic basis of gallbladder cancer
Das, D., Singh, P., Pal, M., Pandey, M., & Dixit, R. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104830 · Cited by 8 · see citing works
ARCELLI, A., Tarantino, G., Cellini, F., Buwenge, M., Macchia, G., Bertini, F., Guido, A., Deodato, F., Cilla, S., Scotti, V., et al. (2023) · Current Oncology · doi:10.3390/curroncol30060427 · Cited by 8 · see citing works
Demiral, S. (2022) · Cancer therapy & Oncology International Journal · doi:10.19080/ctoij.2022.22.556078 · Cited by 8 · see citing works
Radiothérapie stéréotaxique : changement de monde ou effet de mode ?
Vallard, A., Vial, N., Jmour, O., Rehailia-Blanchard, A., Trone, J., Sotton, S., Daguenet, É., Guy, J., & Magné, N. (2019) · Bulletin du Cancer · doi:10.1016/j.bulcan.2019.09.011 · Cited by 8 · see citing works
Bertholet, J., Hunt, A., Dunlop, A., Bird, T., Mitchell, A., Oelfke, U., Nill, S., & Aitken, K. L. (2019) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2019.03.001 · Cited by 8 · see citing works
Zhang, L., Zhang, X., Wu, B., Han, X. N., Guo, C., Li, B., Jing, H., & Cheng, W. M. (2023) · Pathology & Oncology Research · doi:10.3389/pore.2023.1611175 · Cited by 7 · see citing works
S3-Leitlinie Exokrines Pankreaskarzinom – Version 3.1
Seufferlein, T. T. W., Mayerle, J. V., Boeck, S. H., Brunner, T. B., Ettrich, T. J., Grenacher, L., Gress, T. M., Hackert, T., Heinemann, V., Kestler, A. M. R., et al. (2024) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2338-3533 · Cited by 7 · see citing works
Broggi, S., Passoni, P., Tiberio, P., Cicchetti, A., Cattaneo, G. M., Longobardi, B., Mori, M., Reni, M., Slim, N., Vecchio, A. D., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.983984 · Cited by 7 · see citing works
Wu, H., Tsou, H., Lu, L., Lee, H.-L., Chiou, J. F., & Ch’ang, H.-J. (2025) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.02.037 · Cited by 6 · see citing works
Doppenberg, D., Lagerwaard, F. J., van Dieren, S., Meijerink, M. R., van der Vliet, H. J., Besselink, M. G., van Tienhoven, G., Versteijne, E., Slotman, B. J., Wilmink, J. W., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1149961 · Cited by 6 · see citing works
Kamel, R., Dennis, K. E. B., Doody, J., & Pantarotto, J. R. (2023) · Cancers · doi:10.3390/cancers15113016 · Cited by 6 · see citing works
Bhutani, M. S., Narang, A. K., Ding, K., Casey, B. W., Krishnan, K., Koay, E. J., Hong, T. S., Herman, J. M., Griffin, K. H., & Shin, E. J. (2024) · Endoscopy International Open · doi:10.1055/a-2286-1995 · Cited by 6 · see citing works
Contemporary use and outcomes of radiation and chemotherapy for unresectable pancreatic cancer
Moningi, S., Lei, X. J., Fang, P. Q., Taniguchi, C. M., Holliday, E. B., Koay, E. J., Koong, A. C., Ludmir, E. B., Minsky, B. D., Das, P., et al. (2022) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2022.04.007 · Cited by 6 · see citing works
Ohira, S., Koike, Y., Akino, Y., Kanayama, N., Wada, K., Ueda, Y., Masaoka, A., Washio, H., Miyazaki, M., Koizumi, M., et al. (2021) · Physica Medica · doi:10.1016/j.ejmp.2021.03.035 · Cited by 6 · see citing works
Bae, S. H., Jang, W. I., Yu, J. I., Park, H. C., Moon, J. E., Haustermans, K. M., Scorsetti, M., Høyer, M., & Kim, M. S. (2025) · Cancers · doi:10.3390/cancers17182959 · Cited by 5 · see citing works
Assessment of interfraction dose variation in pancreas SBRT using daily simulation MR images
Young, T., Lee, M. T., Johnston, M. L., Nguyen, T. P. T., Ko, R., & Arumugam, S. (2023) · Physical and Engineering Sciences in Medicine · doi:10.1007/s13246-023-01324-6 · Cited by 5 · see citing works
Nie, D., Lan, Q., Shi, B., & Xu, F. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.958257 · Cited by 5 · see citing works
Jung, J. H., Song, C., Jung, I. H., Ahn, J., Kim, B., Jung, K., Lee, J.-C., Kim, J., & Hwang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1050070 · Cited by 5 · see citing works
Wang, H., Mills, B. N., Mislati, R., Ahmed, R., Gerber, S. A., Linehan, D. C., & Doyley, M. M. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.10.005 · Cited by 5 · see citing works
Ashida, R., Fukutake, N., Takada, R., Ioka, T., Ohkawa, K., Katayama, K., Akita, H., Takahashi, H., Ohira, S., & Teshima, T. (2020) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v12.i7.768 · Cited by 5 · see citing works
Stas, D., Vandamme, T., Roeyen, G., Reynders, D., Demey, W., Stellamans, K., Bussels, B., Hutsebaut, I., Maurissen, I., Bouchart, C., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-15041-8 · Cited by 4 · see citing works
Takanen, S., Pinnarò, P., Farina, I., Sperati, F., Botti, C., Vici, P., Soriani, A., Marucci, L., & Sanguineti, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.953810 · Cited by 4 · see citing works
Jang, D. K., Kim, Y. A., Lee, J.-W., Kim, H., Lee, Y. S., Chun, J. W., Lee, J.-C., Woo, S. M., & Hwang, J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113229 · Cited by 4 · see citing works
Felice, F. D., Benevento, I., Bulzonetti, N., Shima, B., Rubini, F., Marampon, F., Musio, D., & Tombolini, V. (2019) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2019.04.003 · Cited by 4 · see citing works
Zhu, J., Xu, Y., & Lu, X. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819830720 · Cited by 4 · see citing works
Samuel, T., Rapic, S., Lindsay, P. E., & DaCosta, R. S. (2024) · Scientific Reports · doi:10.1038/s41598-024-82757-1 · Cited by 3 · see citing works
Xu, X., Yang, Z., Bao, S., Xu, Z., Liu, T., Wu, L., & Lei, J. (2025) · Chemical Science · doi:10.1039/d5sc02482j · Cited by 3 · see citing works
Anticancer Therapy Using FePt Nanoparticles Combined with Nanosecond Pulsed Electric Fields
Hu, S., Zhu, Y. Q., Cheng, P., Dai, G., Jin, L., Wang, Q., Chen, X., & Cai, C. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c03747 · Cited by 3 · see citing works
Zhao, H., Huang, C., Lin, M., Zhou, M., & Huang, C. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12703 · Cited by 3 · see citing works
Huang, L., Chen, L., Wang, Y., Zhang, F., Wang, T., Li, D., Wang, C., & Ma, H. (2023) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2023.22485 · Cited by 3 · see citing works
Wu, T., & Jin, T. (2021) · PubMed Central · Cited by 3 · see citing works
Zhang, B., Kong, X., Zhang, G., Jiang, Z., & Dai, T. (2026) · Radiation Oncology · doi:10.1186/s13014-026-02812-1 · Cited by 2 · see citing works
He, X., Cai, W., Li, F., Zhang, P., Reyngold, M., Cuaron, J. J., Cerviño, L., Li, T., & Li, X. (2022) · Medical Physics · doi:10.1002/mp.15692 · Cited by 2 · see citing works
Effect of stomach size on organs at risk in pancreatic stereotactic body radiotherapy
Tanaka, O., Taniguchi, T., Adachi, K., Nakaya, S., Kiryu, T., Ukai, A., Makita, C., & Matsuo, M. (2022) · Radiation Oncology · doi:10.1186/s13014-022-02107-1 · Cited by 2 · see citing works
Kim, K., Park, H. C., Yu, J. I., Park, J. O., Hong, J. Y., Lee, K. T., Lee, K. H., Lee, J. K., Park, J. K., Heo, J. S., et al. (2024) · Clinical and Translational Radiation Oncology · doi:10.1016/j.ctro.2024.100732 · Cited by 2 · see citing works
Kubo, K., Wadasaki, K., Komichi, D., Sasaki, T., Yamada, H., Matsugu, Y., Itamoto, T., Doi, M., & Shinozaki, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0227305 · Cited by 2 · see citing works
The Role of Radio-Frequency and Stereotactic Ablation in the Treatment of Pancreatic Cancer
Iancu, I., Budusan, M., Capras, D., Odaini, A., Bocse, H., Herdean, A. I., Bolos, T., Breazu, C. M., Dogaru, I., Micu, C. M., et al. (2022) · Chirurgia · doi:10.21614/chirurgia.2759 · Cited by 2 · see citing works
Locally advanced pancreatic cancer successfully treated with high-dose helical tomotherapy
Hama, Y. (2018) · International Cancer Conference Journal · doi:10.1007/s13691-018-0340-3 · Cited by 2 · see citing works
Fiducial Placement for Guidance of Radiotherapy
Cazacu, I. M., Herman, J. M., & Bhutani, M. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-28964-5_12 · Cited by 2 · see citing works
Technical Innovations in the Delivery of Radiation Therapy
Hamilton, R. J. (2022) · Springer eBooks · doi:10.1007/978-3-030-93084-4_63 · Cited by 1 · see citing works
Fogaroli, R. C., de Castro, D. G., Silva, M. L., Pellizzon, A. C. A., Gondim, G. R. M., Chen, M. J., Ramos, H., Neto, E. S., & Abrahão, C. H. (2023) · Cureus · doi:10.7759/cureus.48106 · Cited by 1 · see citing works
Madela, F., Sithole, M., Ntanzi, N., Chiliza, K., Kader, S., Mwazha, A., Thomson, S., & Aldous, C. M. (2024) · South African Journal of Surgery · doi:10.36303/sajs.00329 · Cited by 1 · see citing works
Vincenzi, M. D., Mori, M., Passoni, P., Tummineri, R., Slim, N., Midulla, M., Palazzo, G., Belardo, A., Spezi, E., Picchio, M., et al. (2025) · Cancers · doi:10.3390/cancers17061036 · Cited by 1 · see citing works
Interventional management of pancreatic cancer: Current strategies and future horizons
Wang, Y., Yan, R., Lü, J., Guo, J., & Teng, G. (2025) · Oncology and Translational Medicine · doi:10.1097/ot9.0000000000000097 · Cited by 1 · see citing works
Chen, W., Wang, Z., Yu, L., Guan, Q., Dong, T., Hou, X., Xu, H., Zhang, Y., Jiang, F., Lian, X., et al. (2025) · Radiation Oncology · doi:10.1186/s13014-025-02776-8 · Cited by 1 · see citing works
Matsumoto, K., Maruyama, A., Watanabe, S., Tachibana, R., Yamaguchi, T., Suzuki, K., Kurihara, Y., Maehara, M., Arakawa, S., & Hosokai, Y. (2022) · Radiological Physics and Technology · doi:10.1007/s12194-022-00691-1 · Cited by 1 · see citing works
Emerging Technologies for the Diagnosis and Treatment of Pancreatic Cancer
Swierczewska, M., Козлов, С. В., & Adiseshaiah, P. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811785-9.00022-3 · Cited by 1 · see citing works
- Authors
- de Geus, S. W. L., Eskander, M. F., Kasumova, G. G., Ng, S. C., Kent, T. S., Mancias, J. D., Callery, M. P., Mahadevan, A., & Tseng, J. F.
- Affiliations
- Surgical Outcomes Analysis and Research, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts
- Beth Israel Deaconess Medical Center (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Tseng, Jennifer F.
- ORCID
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 2017-07-14
- Volume
- 123
- Issue
- 21
- Pages
- 4158-4167
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2734591476
- Cited by
- 118
- References
- 33
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 31 · 2021: 14 · 2020: 10 · 2019: 15 · 2018: 7 · 2017: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society (MSRG‐10‐003‐01‐CPHPS)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Keywords
- stereotactic body radiotherapy, pancreatic ductal adenocarcinoma, survival outcomes, chemotherapy, external beam radiotherapy, intensity-modulated radiotherapy, propensity score matching
- MeSH terms
- Adenocarcinoma, Aged, Antineoplastic Agents, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Selection Bias, Databases, Factual, Radiosurgery, Radiotherapy, Intensity-Modulated, Kaplan-Meier Estimate, Propensity Score, Chemoradiotherapy
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