Cited by 118Pancreatic and Hepatic Oncology ResearchAdvanced Radiotherapy TechniquesEndometrial and Cervical Cancer Treatments

Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review

Open access
de Geus, Susanna W. L., Eskander, Mariam F., Kasumova, Gyulnara G., Ng, Sing Chau, Kent, Tara S., Mancias, Joseph D., Callery, Mark P., Mahadevan, Anand +1 more·2017·Cancer

Abstract

BACKGROUND: The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer. METHODS: The National Cancer Data Base was queried for unresected patients who received chemotherapy for nonmetastatic pancreatic adenocarcinoma between 2004 and 2012. Four treatment groups were identified: chemotherapy alone, chemotherapy combined with external‐beam radiotherapy (EBRT), chemotherapy combined with intensity‐modulated radiotherapy (IMRT), and chemotherapy combined with SBRT. Propensity score models predicting the odds of receiving SBRT were created to control for potential selection bias, and patients were matched by propensity scores. The survival analysis was performed with the Kaplan‐Meier method. RESULTS: A total of 14,331 patients met the inclusion criteria. Chemotherapy alone was delivered to 5464 patients (38.1%); 6418 (44.8%), 322 (2.3%), and 2127 (14.8%) received chemotherapy along with EBRT, IMRT, and SBRT, respectively. The unadjusted median survival before matching was 9.9, 10.9, 12.0, and 13.9 months for patients treated with chemotherapy, EBRT, IMRT, and SBRT, respectively. In separate matched analyses, SBRT remained superior to chemotherapy alone (log‐rank P < .0001) and EBRT (log‐rank P = .0180). After matching, survival did not differ between patients receiving IMRT and patients receiving SBRT (log‐rank P = .0492). CONCLUSIONS: SBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158–4167. © 2017 American Cancer Society.

Integrity signals

Registry

Crossref · 10.1002/cncr.30856

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Stereotactic body radiotherapy (SBRT) has significantly better outcomes than chemotherapy alone or in combination with conventional external-beam radiotherapy (EBRT).

    “It has been proven that SBRT has significantly better outcomes than chemotherapy alone or in combination with conventional external-beam radiotherapy (EBRT) 244.”

    From Artificial intelligence in pancreatic cancer (2022) · cites this paper as [244]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
de Geus, S. W. L., Eskander, M. F., Kasumova, G. G., Ng, S. C., Kent, T. S., Mancias, J. D., Callery, M. P., Mahadevan, A., & Tseng, J. F.
Affiliations
  • Surgical Outcomes Analysis and Research, Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts
  • Beth Israel Deaconess Medical Center (US)
  • Brigham and Women's Hospital (US)
Corresponding author
Tseng, Jennifer F.
Venue
Cancer
Publisher
Wiley
Published
2017-07-14
Volume
123
Issue
21
Pages
4158-4167
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
OpenAlex
W2734591476
Cited by
118
References
33
Citations by year
2026: 4 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 31 · 2021: 14 · 2020: 10 · 2019: 15 · 2018: 7 · 2017: 1
FWCI
0.95
Type
journal article
Language
en
Open access
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
Funders
American Cancer Society (MSRG‐10‐003‐01‐CPHPS)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
stereotactic body radiotherapy, pancreatic ductal adenocarcinoma, survival outcomes, chemotherapy, external beam radiotherapy, intensity-modulated radiotherapy, propensity score matching
MeSH terms
Adenocarcinoma, Aged, Antineoplastic Agents, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Retrospective Studies, Selection Bias, Databases, Factual, Radiosurgery, Radiotherapy, Intensity-Modulated, Kaplan-Meier Estimate, Propensity Score, Chemoradiotherapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review