Schapira, Matthieu

Epigenetic protein families: a new frontier for drug discovery

Arrowsmith, C. H., Bountra, C., Fish, P. V., Lee, K., & Schapira, M. (2012) · Nature Reviews Drug Discovery

Epigenetics and DNA MethylationHistone Deacetylase Inhibitors Research

Cited by 1,327

Targeted protein degradation: expanding the toolbox

Schapira, M., Calabrese, M. F., Bullock, A. N., & Crews, C. M. (2019) · Nature Reviews Drug Discovery

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 960

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

WD40 repeat domain proteins: a novel target class?

Schapira, M., Tyers, M., Torrent, M., & Arrowsmith, C. H. (2017) · Nature Reviews Drug Discovery

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 335

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., et al. (2015) · Nature Chemical Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 284

Structural Biology of Human H3K9 Methyltransferases

Wu, H., Min, J., Lunin, V. V., Antoshenko, T., Dombrovski, L., Zeng, H., Allali-Hassani, A., Campagna-Slater, V., Vedadi, M., Arrowsmith, C. H., et al. (2010) · PLoS ONE

Cancer-related gene regulationEpigenetics and DNA Methylation

Cited by 268

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding

Ackloo, S., Al-awar, R., Amaro, R. E., Arrowsmith, C. H., Azevedo, H., Batey, R. A., Bengio, Y., Betz, U. A. K., Bologa, C. G., Chodera, J. D., et al. (2022) · Nature Reviews Chemistry

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 112

UbiHub: a data hub for the explorers of ubiquitination pathways

Liu, L., Damerell, D. R., Koukouflis, L., Tong, Y., Marsden, B. D., & Schapira, M. (2019) · Bioinformatics

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 76

Disease Association and Druggability of WD40 Repeat Proteins

Song, R., Wang, Z.-D., & Schapira, M. (2017) · Journal of Proteome Research

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 45

A resource to enable chemical biology and drug discovery of WDR Proteins

Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A., et al. (2024) · Journal of Medicinal Chemistry

Computational Drug Discovery MethodsProtein Degradation and Inhibitors

Cited by 24