Gersbach, Charles A.

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

Gaj, T., Gersbach, C. A., & Barbas, C. F. (2013) · Trends in Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 3,820

The next generation of CRISPR–Cas technologies and applications

Pickar-Oliver, A., & Gersbach, C. A. (2019) · Nature Reviews Molecular Cell Biology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,459

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

Perez-Pinera, P., Kocak, D. D., Vockley, C. M., Adler, A. F., Kabadi, A. M., Polstein, L. R., Thakore, P. I., Glass, K. A., Ousterout, D. G., Leong, K. W., et al. (2013) · Nature Methods

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,328

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Nelson, C. E., Hakim, C. H., Ousterout, D. G., Thakore, P. I., Moreb, E. A., Rivera, R. M. C., Madhavan, S., Pan, X., Ran, F. A., Yan, W. X., et al. (2016) · Science

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 1,144

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

Thakore, P. I., D'Ippolito, A. M., Song, L., Safi, A., Shivakumar, N. K., Kabadi, A. M., Reddy, T. E., Crawford, G. E., & Gersbach, C. A. (2015) · Nature Methods

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 1,012

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy

Ousterout, D. G., Kabadi, A. M., Thakore, P. I., Majoros, W. H., Reddy, T. E., & Gersbach, C. A. (2015) · Nature Communications

CRISPR and Genetic EngineeringMuscle Physiology and Disorders

Cited by 470

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Thakore, P. I., Black, J. B., Hilton, I. B., & Gersbach, C. A. (2016) · Nature Methods

CRISPR and Genetic EngineeringEpigenetics and DNA Methylation

Cited by 451

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Klann, T. S., Black, J. B., Chellappan, M., Safi, A., Song, L., Hilton, I. B., Crawford, G. E., Reddy, T. E., & Gersbach, C. A. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringGenomics and Chromatin Dynamics

Cited by 447

Increasing the specificity of CRISPR systems with engineered RNA secondary structures

Kocak, D. D., Josephs, E. A., Bhandarkar, V., Adkar, S. S., Kwon, J. B., & Gersbach, C. A. (2019) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 351

Myoblast proliferation and differentiation on fibronectin-coated self-assembled monolayers presenting different surface chemistries

Lan, M. A., Gersbach, C. A., Michael, K. E., Keselowsky, B. G., & García, A. J. (2005) · Biomaterials

Polymer Surface Interaction StudiesCell Adhesion Molecules Research

Cited by 203

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Hakim, C. H., Kumar, S. R. P., Pérez-López, D. O., Wasala, N. B., Zhang, D., Yue, Y., Teixeira, J., Pan, X., Zhang, K., Million, E. D., et al. (2021) · Nature Communications

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 175

Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing

Gonzalez, T. J., Simon, K. E., Blondel, L. O., Fanous, M. M., Roger, A. L., Maysonet, M. S., Devlin, G. W., Smith, T. J., Oh, D. K., Havlik, L. P., et al. (2022) · Nature Communications

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 85