Heimbach, Tycho

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Jones, H., Chen, Y., Gibson, C., Heimbach, T., Parrott, N., Peters, S., Snoeys, J., Upreti, V., Zheng, M., & Hall, S. (2015) · Clinical Pharmacology & Therapeutics

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 488

Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective

Lin, W., Chen, Y., Unadkat, J. D., Zhang, X., Wu, D., & Heimbach, T. (2022) · Pharmaceutical Research

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 137

Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies

Tistaert, C., Heimbach, T., Xia, B., Parrott, N., Samant, T. S., & Kesisoglou, F. (2019) · Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 75

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Margolskee, A., Darwich, A. S., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 69

Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds

Zhang, T., Heimbach, T., Lin, W., Zhang, J., & He, H. (2015) · Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 56

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Darwich, A. S., Margolskee, A., Pepin, X., Aarons, L., Galetin, A., Rostami-Hodjegan, A., Carlert, S., Hammarberg, M., Hilgendorf, C., Johansson, P., et al. (2017) · European Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsComputational Drug Discovery Methods

Cited by 45

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

Xia, B., Heimbach, T., Lin, T.-H., He, H., Wang, Y., & Tan, E. (2012) · Cancer Chemotherapy and Pharmacology

Pharmacogenetics and Drug MetabolismPharmaceutical studies and practices

Cited by 23