Pacifici, Roberto

Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis

Pacifici, R. (1996) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 741

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

Cenci, S., Weitzmann, M. N., Roggia, C., Namba, N., Novack, D., Woodring, J., & Pacifici, R. (2000) · Journal of Clinical Investigation

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 705

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics

Li, J.-Y., Chassaing, B., Tyagi, A. M., Vaccaro, C., Luo, T., Adams, J., Darby, T. M., Weitzmann, M. N., Mulle, J. G., Gewirtz, A. T., et al. (2016) · Journal of Clinical Investigation

Gut microbiota and healthBone Metabolism and Diseases

Cited by 643

Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo

Roggia, C., Gao, Y., Cenci, S., Weitzmann, M. N., Toraldo, G., Isaia, G., & Pacifici, R. (2001) · Proceedings of the National Academy of Sciences

Bone Metabolism and DiseasesEstrogen and related hormone effects

Cited by 513

The gut-bone axis: How bacterial metabolites bridge the distance

Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation

Gut microbiota and healthBone Metabolism and Diseases

Cited by 403

Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-γ-induced class II transactivator

Cenci, S., Toraldo, G., Weitzmann, M. N., Roggia, C., Gao, Y., Qian, W. P., Sierra, O., & Pacifici, R. (2003) · Proceedings of the National Academy of Sciences

Bone Metabolism and DiseasesEstrogen and related hormone effects

Cited by 309

The Functional Block of TNF but Not of IL-6 Prevents Bone Loss in Ovariectomized Mice

Kimble, R. B., Bain, S., & Pacifici, R. (1997) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 241

Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota

Li, J.-Y., Yu, M., Pal, S., Tyagi, A. M., Dar, H., Adams, J., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Journal of Clinical Investigation

Bone Metabolism and DiseasesGut microbiota and health

Cited by 198

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand

Li, J.-Y., Tawfeek, H., Bedi, B., Yang, X., Adams, J., Gao, K. Y., Zayzafoon, M., Weitzmann, M. N., & Pacifici, R. (2011) · Proceedings of the National Academy of Sciences

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 186

Oxidative stress causes bone loss in estrogen-deficient mice through enhanced bone marrow dendritic cell activation

Grassi, F., Tell, G., Robbie-Ryan, M., Gao, Y., Terauchi, M., Yang, X., Romanello, M., Jones, D. P., Weitzmann, M. N., & Pacifici, R. (2007) · Proceedings of the National Academy of Sciences

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 150

PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Yu, M., Malik Tyagi, A., Li, J.-Y., Adams, J., Denning, T. L., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Nature Communications

Gut microbiota and healthBone Metabolism and Diseases

Cited by 148

Estrogen deficiency, T cells and bone loss

Pacifici, R. (2008) · Cellular Immunology

Bone Metabolism and DiseasesEstrogen and related hormone effects

Cited by 146

Role of T cells in ovariectomy induced bone loss—revisited

Pacifici, R. (2012) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 142

Evolutionary medicine and bone loss in chronic inflammatory diseases—A theory of inflammation-related osteopenia

Straub, R. H., Cutolo, M., & Pacifici, R. (2015) · Seminars in Arthritis and Rheumatism

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 132

From osteoimmunology to osteomicrobiology: How the microbiota and the immune system regulate bone

Hsu, E., & Pacifici, R. (2018) · Calcified Tissue International

Bone Metabolism and DiseasesGut microbiota and health

Cited by 106

Bone Remodeling and the Microbiome

Pacifici, R. (2018) · Cold Spring Harbor Perspectives in Medicine

Gut microbiota and healthBone Metabolism and Diseases

Cited by 101

Callus γδ T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice

Dar, H. Y., Perrien, D. S., Pal, S., Stoica, A., Uppuganti, S., Nyman, J. S., Jones, R. M., Weitzmann, M. N., & Pacifici, R. (2023) · Journal of Clinical Investigation

Bone fractures and treatmentsT-cell and B-cell Immunology

Cited by 48

Antacid and sucralfate-induced hypophosphatemic osteomalacia: A case report and review of the literature

Chines, A., & Pacifici, R. (1990) · Calcified Tissue International

Parathyroid Disorders and TreatmentsVitamin D Research Studies

Cited by 44

Estrogen Deficiency, Postmenopausal Osteoporosis, and Age-Related Bone Loss

Khosla, S., & Pacifici, R. (2013) · Osteoporosis

Bone health and osteoporosis researchBone Metabolism and Diseases

Cited by 31

Adrenal responses to subtotal parathyroidectomy for primary hyperparathyroidism

Pacifici, R., Perry, H. M., Shieber, W., Biglieri, E., Droke, D. M., & Avioli, L. V. (1987) · Calcified Tissue International

Parathyroid Disorders and TreatmentsHormonal Regulation and Hypertension

Cited by 19