Cited by 405Gut microbiota and healthBone Metabolism and DiseasesBone health and osteoporosis research

The gut-bone axis: How bacterial metabolites bridge the distance

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Zaiss, Mario M., Jones, Rheinallt M., Schett, Georg, Pacifici, Roberto·2019·Journal of Clinical Investigation

Abstract

The gut microbiome is a key regulator of bone health that affects postnatal skeletal development and skeletal involution. Alterations in microbiota composition and host responses to the microbiota contribute to pathological bone loss, while changes in microbiota composition that prevent, or reverse, bone loss may be achieved by nutritional supplements with prebiotics and probiotics. One mechanism whereby microbes influence organs of the body is through the production of metabolites that diffuse from the gut into the systemic circulation. Recently, short-chain fatty acids (SCFAs), which are generated by fermentation of complex carbohydrates, have emerged as key regulatory metabolites produced by the gut microbiota. This Review will focus on the effects of SCFAs on the musculoskeletal system and discuss the mechanisms whereby SCFAs regulate bone cells.

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  • Short-chain fatty acids are potent regulators of osteoclast activity and bone metabolism.

    “Beyond their influence on the GI tract, SCFAs have emerged as potent regulators of osteoclast activity and bone metabolism [31].”

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Authors
Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R.
Affiliations
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • Emory University (US)
Corresponding author
Pacifici, Roberto
Venue
Journal of Clinical Investigation
Published
2019-07-15
Volume
129
Issue
8
Pages
3018-3028
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
OpenAlex
W2957498904
Cited by
403
References
168
Citations by year
2026: 83 · 2025: 65 · 2024: 69 · 2023: 63 · 2022: 45 · 2021: 48 · 2020: 24 · 2019: 5
FWCI
2.69
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Emory University
  • Georgia Clinical and Translational Science Alliance
  • Johannes und Frieda Marohn-Stiftung
  • Deutsche Forschungsgemeinschaft (CRC‐1181, FOR2886, DFG – FOR 2886 “PANDORA”, DFG-FOR2886, FOR2886 - PANDORA, DFG–CRC1181)
  • Else Kröner-Fresenius-Stiftung
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119229, R01DK108842, R01DK112946, R01DK098391)
  • National Center for Research Resources (S10RR028009)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
gut-bone axis, gut microbiota, bone health, short-chain fatty acids, bacterial metabolites, bone loss, postnatal skeletal development, prebiotics, probiotics, bone cells, musculoskeletal system
MeSH terms
Gastrointestinal Microbiome, Animals, Bone Diseases, Metabolic, Fatty Acids, Volatile, Humans, Probiotics, Prebiotics

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