Chen, Michelle B.

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Agam, M., Maat, C. A., Losada, P. M., Chen, M. B., Schaum, N., Khoury, N., et al. (2022) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 797

Ageing hallmarks exhibit organ-specific temporal signatures

Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 671

Physiological blood–brain transport is impaired with age by a shift in transcytosis

Yang, A. C., Stevens, M. Y., Chen, M. B., Lee, D. P., Stähli, D., Gate, D., Contrepois, K., Chen, W., Iram, T., Zhang, L., et al. (2020) · Nature

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 477

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., et al. (2019) · Nature Medicine

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 442

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Chen, M. B., Whisler, J. A., Fröse, J., Yu, C., Shin, Y., & Kamm, R. D. (2017) · Nature Protocols

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 385

Mechanisms of tumor cell extravasation in an in vitro microvascular network platform

Chen, M. B., Whisler, J. A., Jeon, J. S., & Kamm, R. D. (2013) · Integrative Biology

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 308

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, M. B., Yang, A. C., Yousef, H., Lee, D., Chen, W., Schaum, N., Lehallier, B., Quake, S. R., & Wyss-Coray, T. (2020) · Cell Reports

Barrier Structure and Function StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 233

Microfluidics: A New Tool for Modeling Cancer–Immune Interactions

Boussommier-Calleja, A., Li, R., Chen, M. B., Wong, S. C., & Kamm, R. D. (2016) · Trends in Cancer

3D Printing in Biomedical ResearchMicrofluidic and Capillary Electrophoresis Applications

Cited by 224

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

Chen, M. B., Hajal, C., Benjamin, D. C., Yu, C., Azizgolshani, H., Hynes, R. O., & Kamm, R. D. (2018) · Proceedings of the National Academy of Sciences

Chemokine receptors and signalingImmune cells in cancer

Cited by 183

Spatial transcriptomics reveal neuron–astrocyte synergy in long-term memory

Sun, W., Liu, Z., Jiang, X., Chen, M. B., Dong, H., Liu, J., Südhof, T. C., & Quake, S. R. (2024) · Nature

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 165

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

Persistent transcriptional programmes are associated with remote memory

Chen, M. B., Jiang, X., Quake, S. R., & Südhof, T. C. (2020) · Nature

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 111

A human brain vascular atlas reveals diverse cell mediators of Alzheimer’s disease risk

Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Maat, C. A., Losada, P. M., Chen, M. B., Agam, M., Schaum, N., Khoury, N., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory)

Barrier Structure and Function StudiesSingle-cell and spatial transcriptomics

Cited by 48