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Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

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Microfluidic tumor-on-a-chip model to evaluate the role of tumor environmental stress on NK cell exhaustion

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Engineered 3D vascular and neuronal networks in a microfluidic platform

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IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids

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The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

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In Vitro Microfluidic Models for Neurodegenerative Disorders

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Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering

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Biology and Models of the Blood–Brain Barrier

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Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling

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Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation

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Engineered models to parse apart the metastatic cascade

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Tumor-on-chip modeling of organ-specific cancer and metastasis

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Applications of tumor chip technology

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Endothelial Regulation of Drug Transport in a 3D Vascularized Tumor Model

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3D bioprinting of collagen-based high-resolution internally perfusable scaffolds for engineering fully biologic tissue systems

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Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature‐on‐a‐Chip System Correlates with Tumor Heterogeneity and Subtypes

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Cancer Modeling‐on‐a‐Chip with Future Artificial Intelligence Integration

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Immunotherapy discovery on tumor organoid-on-a-chip platforms that recapitulate the tumor microenvironment

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A 3D human renal cell carcinoma-on-a-chip for the study of tumor angiogenesis

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Personalized Vascularized Tumor Organoid‐on‐a‐Chip for Tumor Metastasis and Therapeutic Targeting Assessment

Du, Y., Wang, Y., Bao, Q., Xu, X., Xu, C., Wang, S., Liu, Q., Liu, F., Zeng, Y., Wang, Y., et al. (2024) · Advanced Materials · doi:10.1002/adma.202412815 · Cited by 94 · see citing works

Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer

Saha, B., Mathur, T., Tronolone, J. J., Chokshi, M., Lokhande, G. K., Selahi, A., Gaharwar, A. K., Afshar-Kharghan, V., Sood, A. K., Bao, G., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg5283 · Cited by 90 · see citing works

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations

Ayuso, J. M., Gillette, A. A., Lugo-Cintrón, K. M., Acevedo‐Acevedo, S., Gomez, I., Morgan, M. M., Heaster, T. M., Wisinski, K. B., Palecek, S. P., Skala, M. C., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.046 · Cited by 90 · see citing works

Bioprinting of in vitro tumor models for personalized cancer treatment: a review

Mao, S., Pang, Y., Liu, T., Shao, Y., He, J., Yang, H., Mao, Y., & Sun, W. (2020) · Biofabrication · doi:10.1088/1758-5090/ab97c0 · Cited by 89 · see citing works

Construction of multi-scale vascular chips and modelling of the interaction between tumours and blood vessels

Nie, J., Gao, Q., Xie, C., Lv, S., Qiu, J., Liu, Y., Guo, M. A., Guo, R., Fu, J., & He, Y. (2019) · Materials Horizons · doi:10.1039/c9mh01283d · Cited by 89 · see citing works

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines

Song, J., Miermont, A., Lim, C. T., & Kamm, R. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-36381-5 · Cited by 87 · see citing works

Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant read-outs for tissue permeability and vascular structure

Arık, Y. B., Buijsman, W., Loessberg-Zahl, J., Cuartas-Vélez, C., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., et al. (2020) · Lab on a Chip · doi:10.1039/d0lc00639d · Cited by 87 · see citing works

The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination

Offeddu, G. S., Hajal, C., Foley, C., Wan, Z., Ibrahim, L. I., Coughlin, M. F., & Kamm, R. D. (2021) · Communications Biology · doi:10.1038/s42003-021-01774-2 · Cited by 87 · see citing works

Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models

Papa, A., Jiang, A. R., Korin, N., Chen, M. B., Langan, E. T., Waterhouse, A., Nash, E., Caroff, J., Graveline, A. R., Vernet, A., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau5898 · Cited by 86 · see citing works

Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis

Osaki, T., Sivathanu, V., & Kamm, R. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.041 · Cited by 85 · see citing works

Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation

Wang, W. Y., Lin, D., Jarman, E. H., Polacheck, W. J., & Baker, B. M. (2020) · Lab on a Chip · doi:10.1039/c9lc01170f · Cited by 85 · see citing works

Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

Lim, J., Ching, H., Yoon, J., Jeon, N. L., & Kim, Y. (2021) · Nano Convergence · doi:10.1186/s40580-021-00261-y · Cited by 83 · see citing works

Microfluidics for studying metastatic patterns of lung cancer

Ruzycka-Ayoush, M., Cimpan, M. R., Ríos-Mondragón, I., & Grudziński, I. P. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0492-0 · Cited by 82 · see citing works

Examining metastatic behavior within 3D bioprinted vasculature for the validation of a 3D computational flow model

Hynes, W. F., Pepona, M., Robertson, C., Alvarado, J. A., Dubbin, K., Triplett, M., Adorno, J. J., Randles, A. P., & Moya, M. L. (2020) · Science Advances · doi:10.1126/sciadv.abb3308 · Cited by 82 · see citing works

Recent advances for cancer detection and treatment by microfluidic technology, review and update

Bargahi, N., Ghasemali, S., Jahandar-Lashaki, S., & Nazari, A. (2022) · Biological Procedures Online · doi:10.1186/s12575-022-00166-y · Cited by 82 · see citing works

The current landscape of 3D in vitro tumor models: what cancer hallmarks are accessible for drug discovery?

Rodenhizer, D., Dean, T., D'Arcangelo, E., & McGuigan, A. P. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701174 · Cited by 80 · see citing works

Tumor cell nuclei soften during transendothelial migration

Roberts, A. B., Zhang, J., Singh, V. R., Nikolić, M., Moeendarbary, E., Kamm, R. D., So, P. T. C., & Scarcelli, G. (2021) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2021.110400 · Cited by 79 · see citing works

Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling

Fröse, J., Chen, M. B., Hebron, K. E., Reinhardt, F., Hajal, C., Zijlstra, A., Kamm, R. D., & Weinberg, R. A. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.092 · Cited by 79 · see citing works

In Vitro Modeling of Mechanics in Cancer Metastasis

Malandrino, A., Kamm, R. D., & Moeendarbary, E. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00041 · Cited by 78 · see citing works

Squeezing through the microcirculation: survival adaptations of circulating tumour cells to seed metastasis

Paizal, J. P., Au, S. H., & Bakal, C. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01176-x · Cited by 77 · see citing works

Breast tumor-on-chip models: From disease modeling to personalized drug screening

Bano, S., Dahiya, U. R., Mishra, S., Ayache, J., Casquillas, G. V., Caballero, D., Reis, R. L., & Kundu, S. C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.12.057 · Cited by 75 · see citing works

Multifunctional microfluidic chip for cancer diagnosis and treatment

Guo, Q., Zhang, L.-L., Liu, J., Li, Z., Li, J.-J., Zhou, W., Wang, H., Li, J., Liu, D., Yu, X., et al. (2020) · Nanotheranostics · doi:10.7150/ntno.49614 · Cited by 74 · see citing works

Balance of mechanical forces drives endothelial gap formation and may facilitate cancer and immune-cell extravasation

Escribano, J., Chen, M. B., Moeendarbary, E., Cao, X., Shenoy, V. B., García‐Aznar, J. M., Kamm, R. D., & Spill, F. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1006395 · Cited by 74 · see citing works

Recapitulating the vasculature using ORGAN-ON-CHIP technology

Pollet, A. M. A. O., & den Toonder, J. M. J. (2020) · Bioengineering · doi:10.3390/bioengineering7010017 · Cited by 73 · see citing works

Pericytes enable effective angiogenesis in the presence of proinflammatory signals

Kang, T.-Y., Bocci, F., Jolly, M. K., Levine, H., Onuchic, J. N., & Levchenko, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913373116 · Cited by 73 · see citing works

Microfluidic Organoid Cultures Derived from Pancreatic Cancer Biopsies for Personalized Testing of Chemotherapy and Immunotherapy

Choi, D., Gonzalez‐Suarez, A. M., Dumbrava, M. G., Medlyn, M. J., de Hoyos‐Vega, J. M., Cichocki, F. M., Miller, J. S., Li, D., Zhu, M., Stybayeva, G., et al. (2023) · Advanced Science · doi:10.1002/advs.202303088 · Cited by 73 · see citing works

Human‐on‐Leaf‐Chip: A Biomimetic Vascular System Integrated with Chamber‐Specific Organs

Mao, M., Bei, H. P., Lam, C. H., Chen, P., Wang, S., Chen, Y., He, J., & Zhao, X. (2020) · Small · doi:10.1002/smll.202000546 · Cited by 71 · see citing works

Patient-derived organoids (PDOs) and PDO-derived xenografts (PDOXs): New opportunities in establishing faithful pre-clinical cancer models

Wang, E., Xiang, K., Zhang, Y., & Wang, X. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.10.001 · Cited by 70 · see citing works

The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain

Hajal, C., Shin, Y., Li, L., Serrano, J. C., Jacks, T., & Kamm, R. D. (2021) · Science Advances · doi:10.1126/sciadv.abg8139 · Cited by 69 · see citing works

Tumor Microenvironment on a Chip: The Progress and Future Perspective

Ahn, J., Sei, Y. J., Jeon, N. L., & Kim, Y. (2017) · Bioengineering · doi:10.3390/bioengineering4030064 · Cited by 69 · see citing works

Emerging tumor-on-chips with electrochemical biosensors

Lei, L., Ma, B., Xu, C., & Liu, H. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116640 · Cited by 69 · see citing works

Microsystem Advances through Integration with Artificial Intelligence

Tsai, H., Podder, S., & Chen, P. (2023) · Micromachines · doi:10.3390/mi14040826 · Cited by 69 · see citing works

Cooperative Effects of Vascular Angiogenesis and Lymphangiogenesis

Osaki, T., Serrano, J. C., & Kamm, R. D. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0054-2 · Cited by 69 · see citing works

The effects of luminal and trans-endothelial fluid flows on the extravasation and tissue invasion of tumor cells in a 3D in vitro microvascular platform

Hajal, C., Ibrahim, L., Serrano, J. C., Offeddu, G. S., & Kamm, R. D. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120470 · Cited by 68 · see citing works

Advanced technological tools to study multidrug resistance in cancer

Andrei, L., Kasas, S., Ochoa, I., Stanković, T., Korsnes, M. S., Václavíková, R., Assaraf, Y. G., & Pešić, M. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100658 · Cited by 67 · see citing works

Cancer-on-chip models for metastasis: importance of the tumor microenvironment

Jouybar, M., de Winde, C. M., Wolf, K., Friedl, P., Mebius, R. E., & den Toonder, J. M. J. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.10.001 · Cited by 66 · see citing works

Biomaterials to model and measure epithelial cancers

Beri, P., Matte, B. F., Fattet, L., Kim, D., Yang, J., & Engler, A. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0051-6 · Cited by 66 · see citing works

Dynamic hydrogels for biofabrication: A review

Xu, R., Ooi, H. S., Bian, L., Ouyang, L., & Sun, W. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123266 · Cited by 65 · see citing works

Sound-induced morphogenesis of multicellular systems for rapid orchestration of vascular networks

Petta, D., Basoli, V., Pellicciotta, D., Tognato, R., Barcik, J. P., Arrigoni, C., Bella, E. D., Armiento, A. R., Candrian, C., Richards, R. G., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/abbb9c · Cited by 64 · see citing works

OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer

Saha, B., Mathur, T., Handley, K. F., Hu, W., Afshar-Kharghan, V., Sood, A. K., & Jain, A. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001632 · Cited by 63 · see citing works

A Robust Method for Perfusable Microvascular Network Formation In Vitro

Wan, Z., Zhong, A. X., Zhang, S., Pavlou, G., Coughlin, M. F., Shelton, S. E., Nguyen, H. T., Lorch, J. H., Barbie, D. A., & Kamm, R. D. (2022) · Small Methods · doi:10.1002/smtd.202200143 · Cited by 63 · see citing works

Platelet cancer cell interplay as a new therapeutic target

Morris, K., Schnoor, B., & Papa, A. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188770 · Cited by 63 · see citing works

Refining Cancer Management Using Integrated Liquid Biopsy

Qiu, J., Xu, J., Zhang, K., Gu, W., Nie, L., Wang, G., & Luo, Y. (2020) · Theranostics · doi:10.7150/thno.40677 · Cited by 63 · see citing works

Development of a perfusable, hierarchical microvasculature-on-a-chip model

Chen, S. W., Blazeski, A., Zhang, S., Shelton, S. E., Offeddu, G. S., & Kamm, R. D. (2023) · Lab on a Chip · doi:10.1039/d3lc00512g · Cited by 62 · see citing works

Degradation of extracellular matrix regulates osteoblast migration: A microfluidic-based study

Movilla, N., Borau, C., Valero, C., & García‐Aznar, J. M. (2017) · Bone · doi:10.1016/j.bone.2017.10.025 · Cited by 62 · see citing works

Tumor-Derived cGAMP Regulates Activation of the Vasculature

Campisi, M., Sundararaman, S. K., Shelton, S. E., Knelson, E. H., Mahadevan, N. R., Yoshida, R., Tani, T., Ivanova, E. V., Cañadas, I., Osaki, T., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02090 · Cited by 62 · see citing works

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan, S., Banda, O. A., Farino, C. J., Sperduto, J. L., Keller, K. A., Taitano, R. A., & Slater, J. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901255 · Cited by 61 · see citing works

Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials

Zhang, P., Shao, N., & Qin, L. (2021) · Advanced Materials · doi:10.1002/adma.202005944 · Cited by 61 · see citing works

Engineering in vitro vascular microsystems

Liu, Q., Ying, G., Hu, C., Du, L., Zhang, H., Wang, Z., Yue, H., Yetisen, A. K., Wang, G., Shen, Y., et al. (2025) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-00956-w · Cited by 61 · see citing works

The Use of Microfluidic Platforms to Probe the Mechanism of Cancer Cell Extravasation

Coughlin, M. F., & Kamm, R. D. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901410 · Cited by 59 · see citing works

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

Bouquerel, C., Dubrova, A., Hofer, I., Phan, D. T. T., Bernheim, M., Ladaigue, S., Cavaniol, C., Maddalo, D., Cabel, L., Mechta-Grigoriou, F., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00531c · Cited by 58 · see citing works

Microfluidic platforms for modeling biological barriers in the circulatory system

Yu, F., Kumar, N. D. O. S., Choudhury, D., Foo, L. C., & Ng, S. H. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.036 · Cited by 58 · see citing works

Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials

Shih, Y.-R. V., & Varghese, S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.005 · Cited by 57 · see citing works

Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier

Yan, L., Moriarty, R. A., & Stroka, K. M. (2021) · Theranostics · doi:10.7150/thno.63195 · Cited by 56 · see citing works

Ebola Hemorrhagic Shock Syndrome-on-a-Chip

Junaid, A., Tang, H., van Reeuwijk, A., Abouleila, Y., Wuelfroth, P., van Duinen, V., Stam, W., van Zonneveld, A. J., Hankemeier, T., & Mashaghi, A. (2019) · iScience · doi:10.1016/j.isci.2019.100765 · Cited by 56 · see citing works

On-chip human microvasculature for real-time visualization and quantification of tumor cell extravasation and early metastatic seeding

Chen, M. B., Whisler, J. A., Boussommier-Calleja, A., & Kamm, R. D. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/conf.fbioe.2016.01.00722 · Cited by 1 · see citing works

The mechanics and mechanisms of tumor cell extravasation (Conference Presentation)

Kamm, R. D. (2018) · Optical Elastography and Tissue Biomechanics · doi:10.1117/12.2297494

Microfluidic device for studying tumor cell extravasation in cancer metastasis

Reese, B. E., Zheng, S., Evans, B. M., Datar, R. H., Thundat, T. G., & Lin, H. K. (2010) · Biomedical Sciences and Engineering Conference (BSEC) · doi:10.1109/bsec.2010.5510818 · Cited by 3 · see citing works

Microfluidic vascular models of tumor cell extravasation

Kim, S., Wan, Z., Jeon, J. S., & Kamm, R. D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1052192 · Cited by 25 · see citing works

Abstract 2824: In vitro tumor extravasation model.

Jeon, J. S., Zervantonakis, I. K., Chung, S. H., Charest, J. L., & Kamm, R. D. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-2824