Steidl, Ulrich

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 689

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Carvajal, L. A., Neriah, D. B., Senecal, A., Benard, L., Thiruthuvanathan, V., Yatsenko, T., Narayanagari, S.-R., Wheat, J. C., Todorova, T. I., Mitchell, K., et al. (2018) · Science Translational Medicine

Cancer-related Molecular PathwaysAcute Myeloid Leukemia Research

Cited by 249

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 237

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., et al. (2015) · Cancer Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 236

Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

Gañán-Gómez, I., Wei, Y., Starczynowski, D. T., Colla, S., Yang, H., Cabrero-Calvo, M., Bohannan, Z. S., Verma, A., Steidl, U., & Garcia-Manero, G. (2015) · Leukemia

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 236

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS

Barreyro, L., Will, B., Bartholdy, B., Zhou, L., Todorova, T. I., Stanley, R. F., Ben-Neriah, S., Montagna, C., Parekh, S., Pellagatti, A., et al. (2012) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 201

Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

Steidl, U., Rosenbauer, F., Verhaak, R. G. W., Gu, X., Ebralidze, A., Otu, H. H., Klippel, S., Steidl, C., Bruns, I., Costa, D. B., et al. (2006) · Nature Genetics

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 184

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia

Okoye-Okafor, U. C., Bartholdy, B., Cartier, J., Gao, E. N., Pietrak, B., Rendina, A. R., Rominger, C., Quinn, C., Smallwood, A., Wiggall, K. J., et al. (2015) · Nature Chemical Biology

Acute Myeloid Leukemia ResearchGlioma Diagnosis and Treatment

Cited by 180

Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53

Saleh, M. N., Patel, M. R., Bauer, T. M., Goel, S., Falchook, G. S., Shapiro, G. I., Chung, K. Y., Infante, J. R., Conry, R. M., Rabinowits, G., et al. (2021) · Clinical Cancer Research

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 159

Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia

Will, B., Vogler, T. O., Narayanagari, S., Bartholdy, B., Todorova, T. I., da Silva Ferreira, M., Chen, J., Yu, Y., Mayer, J., Barreyro, L., et al. (2015) · Nature Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 127

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Antony-Debré, I., Paul, A., Leite, J., Mitchell, K., Kim, H. M., Carvajal, L. A., Todorova, T. I., Huang, K., Kumar, A., Farahat, A. A., et al. (2017) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 120

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.-J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., et al. (2007) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 114

IL1RAP potentiates multiple oncogenic signaling pathways in AML

Mitchell, K., Barreyro, L., Todorova, T. I., Taylor, S. J., Antony-Debré, I., Narayanagari, S.-R., Carvajal, L. A., Leite, J., Piperdi, Z., Pendurti, G., et al. (2018) · Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 97

Single-molecule imaging of transcription dynamics in somatic stem cells

Wheat, J. C., Sella, Y., Willcockson, M., Skoultchi, A. I., Bergman, A., Singer, R. H., & Steidl, U. (2020) · Nature

Gene Regulatory Network AnalysisSingle-cell and spatial transcriptomics

Cited by 88

Role of Transcription Factors C/EBPa and PU.1 in Normal Hematopoiesis and Leukemia

Koschmieder, S., Rosenbauer, F., Steidl, U., Owens, B. M., & Tenen, D. G. (2005) · International Journal of Hematology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 72

Multiple Myeloma and Its Precursor Disease Among Firefighters Exposed to the World Trade Center Disaster

Landgren, O., Zeig-Owens, R., Giricz, O., Goldfarb, D., Murata, K., Thoren, K., Ramanathan, L., Hultcrantz, M., Dogan, A., Nwankwo, G., et al. (2018) · JAMA Oncology

Multiple Myeloma Research and TreatmentsOccupational Health and Performance

Cited by 55

A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1

Wontakal, S. N., Guo, X., Will, B., Shi, M., Raha, D., Mahajan, M. C., Weissman, S., Snyder, M., Steidl, U., Zheng, D., et al. (2011) · PLoS Genetics

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 53

Pharmacological Restriction of Genomic Binding Sites Redirects PU.1 Pioneer Transcription Factor Activity

Taylor, S. J., Stauber, J., Bohorquez, O., Tatsumi, G., Kumari, R., Chakraborty, J., Bartholdy, B. A., Schwenger, E., Sundaravel, S., Farahat, A. A., et al. (2024) · Nature Genetics

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 22