Schwabe, John W. R.

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

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The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

Schwabe, J. W. R., Chapman, L., Finch, J. T., & Rhodes, D. (1993) · Cell

Estrogen and related hormone effectsProtein Structure and Dynamics

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Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate

Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature

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Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

Millard, C. J., Watson, P. J., Celardo, I., Gordiyenko, Y., Cowley, S. M., Robinson, C. V., Fairall, L., & Schwabe, J. W. R. (2013) · Molecular Cell

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A Mutation in the Thyroid Hormone Receptor Alpha Gene

Bochukova, E., Schoenmakers, N., Agostini, M., Schoenmakers, E., Rajanayagam, O., Keogh, J. M., Henning, E., Reinemund, J., Gevers, E., Sarri, M., et al. (2012) · New England Journal of Medicine

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A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

Dickens, L. S., Boyd, R. S., Jukes-Jones, R., Hughes, M. A., Robinson, G. L., Fairall, L., Schwabe, J. W. R., Cain, K., & MacFarlane, M. (2012) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

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Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Schoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation

Selenium in Biological SystemsOrganoselenium and organotellurium chemistry

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Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Sandhu, J., Li, S., Fairall, L., Pfisterer, S. G., Gurnett, J. E., Xiao, X., Weston, T. A., Vashi, D., Ferrari, A., Orozco, J. L., et al. (2018) · Cell

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Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Hughes, M. A., Powley, I. R., Jukes-Jones, R., Horn, S., Feoktistova, M., Fairall, L., Schwabe, J. W. R., Leverkus, M., Cain, K., & MacFarlane, M. (2016) · Molecular Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L., & Schwabe, J. W. R. (2016) · Nature Communications

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Targeting Class I Histone Deacetylases in a “Complex” Environment

Millard, C. J., Watson, P. J., Fairall, L., & Schwabe, J. W. R. (2017) · Trends in Pharmacological Sciences

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Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., et al. (2011) · Nature Structural & Molecular Biology

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Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo

Kelly, R. D. W., Chandru, A., Watson, P. J., Song, Y., Blades, M., Robertson, N. S., Jamieson, A. G., Schwabe, J. W. R., & Cowley, S. M. (2018) · Scientific Reports

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PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes

Smalley, J. P., Adams, G. E., Millard, C. J., Song, Y., Norris, J. K. S., Schwabe, J. W. R., Cowley, S. M., & Hodgkinson, J. T. (2020) · Chemical Communications

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The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

Turnbull, R. E., Fairall, L., Saleh, A., Kelsall, E., Morris, K. L., Ragan, T. J., Savva, C. G., Chandru, A., Millard, C. J., Makarova, O. V., et al. (2020) · Nature Communications

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Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors

Codina, A., Love, J. D., Li, Y., Lazar, M. A., Neuhaus, D., & Schwabe, J. W. R. (2005) · Proceedings of the National Academy of Sciences

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Mutations in TBL1X Are Associated With Central Hypothyroidism

Heinen, C. A., Losekoot, M., Sun, Y., Watson, P. J., Fairall, L., Joustra, S. D., Zwaveling-Soonawala, N., Oostdijk, W., van den Akker, E. L. T., Alders, M., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

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The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Zhang, L., Fairall, L., Goult, B. T., Calkin, A. C., Hong, C., Millard, C. J., Tontonoz, P., & Schwabe, J. W. R. (2011) · Genes & Development

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A specific mutation in TBL1XR1 causes Pierpont syndrome

Heinen, C. A., Jongejan, A., Watson, P. J., Redeker, B., Boelen, A., Boudzovitch-Surovtseva, O., Forzano, F., Hordijk, R., Kelley, R., Olney, A. H., et al. (2016) · Journal of Medical Genetics

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FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

Calkin, A. C., Goult, B. T., Zhang, L., Fairall, L., Hong, C., Schwabe, J. W. R., & Tontonoz, P. (2011) · Proceedings of the National Academy of Sciences

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Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake

Ferrari, A., Whang, E., Xiao, X., Kennelly, J. P., Romartinez-Alonso, B., Mack, J. J., Weston, T., Chen, K., Kim, Y., Tol, M. J., et al. (2023) · Science

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Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins

Moran, C., Agostini, M., McGowan, A., Schoenmakers, E., Fairall, L., Lyons, G., Rajanayagam, O., Watson, L., Offiah, A., Barton, J., et al. (2017) · Thyroid®

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BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

Weber, K., Harper, N., Schwabe, J., & Cohen, G. M. (2013) · Cell Reports

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Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation

Alshehri, A., Baker, I.-M., English, D. M., Fairall, L., Collins, M. O., Schwabe, J. W., & Cowley, S. M. (2025) · Nucleic Acids Research

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