Breed, Jason

Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2

Popovic, B., Breed, J., Rees, D. G., Gardener, M. J., Vinall, L. M. K., Kemp, B., Spooner, J., Keen, J., Minter, R., Uddin, F., et al. (2017) · Journal of Molecular Biology

Monoclonal and Polyclonal Antibodies ResearchCytokine Signaling Pathways and Interactions

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KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

Bery, N., Legg, S., Debreczeni, J., Breed, J., Embrey, K., Stubbs, C., Kolasinska-Zwierz, P., Barrett, N., Marwood, R., Watson, J., et al. (2019) · Nature Communications

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

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Computational design of epitope-specific functional antibodies

Nimrod, G., Fischman, S., Austin, M., Herman, A., Keyes, F., Leiderman, O., Hargreaves, D., Strajbl, M., Breed, J., Klompus, S., et al. (2018) · Cell Reports

Protein Structure and DynamicsMonoclonal and Polyclonal Antibodies Research

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Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold

Castells-Graells, R., Meador, K., Arbing, M. A., Sawaya, M. R., Gee, M., Cascio, D., Gleave, E., Debreczeni, J. É., Breed, J., Leopold, K., et al. (2023) · Proceedings of the National Academy of Sciences

Advanced Electron Microscopy Techniques and ApplicationsEnzyme Structure and Function

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