Che, Jianwei

Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development

Donovan, K. A., Ferguson, F. M., Bushman, J. W., Eleuteri, N. A., Bhunia, D., Ryu, S., Tan, L., Shi, K., Yue, H., Liu, X., et al. (2020) · Cell

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 359

Discovery and resistance mechanism of a selective CDK12 degrader

Jiang, B., Gao, Y., Che, J., Lu, W., Kaltheuner, I. H., Dries, R., Kalocsay, M., Berberich, M. J., Jiang, J., You, I., et al. (2021) · Nature Chemical Biology

Protein Degradation and InhibitorsHistone Deacetylase Inhibitors Research

Cited by 150

Fragment-based covalent ligand discovery

Lu, W., Kostic, M., Zhang, T., Che, J., Patricelli, M. P., Jones, L. H., Chouchani, E. T., & Gray, N. S. (2021) · RSC Chemical Biology

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 136

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

Fan, M., Lu, W., Che, J., Kwiatkowski, N. P., Gao, Y., Seo, H.-S., Ficarro, S. B., Gokhale, P. C., Liu, Y., Geffken, E. A., et al. (2022) · eLife

Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms research

Cited by 68

Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine

Du, G., Rao, S., Gurbani, D., Henning, N. J., Jiang, J., Che, J., Yang, A., Ficarro, S. B., Marto, J. A., Aguirre, A. J., et al. (2020) · Journal of Medicinal Chemistry

Heterocyclic Compound Synthesis and BioactivityProtein Kinase Regulation and GTPase Signaling

Cited by 39