Fragment-based covalent ligand discovery
Open accessAbstract
Covalent fragment-based ligand discovery greatly facilitates the discovery of useful fragments for drug discovery and helps unveil chemical-tractable biological targets in native biological systems.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Covalent ligand screening from electrophilic compound libraries is becoming more common.
“Covalent ligand screening is another ligand discovery approach that is becoming more common, whereby various methods are used to discover covalent ligands from libraries of electrophilic compounds7,12,13.”
From Advances in covalent drug discovery (2022) · cites this paper as [13]
Over the past decade, covalent ligand discovery has shifted towards screening more drug-like electrophilic fragments.
“Over the past decade, covalent ligand discovery has shifted towards screening more drug-like electrophilic fragments13.”
From Advances in covalent drug discovery (2022) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 121 · Cited by 136
Research works printed but not linked: 7
- Strelow J. M. SLAS Discovery 2017 22 3 20 27703080
- Xiao H. Jedrychowski M. P. Schweppe D. K. Huttlin E. L. Yu Q. Heppner D. E. Li J. Long J. Mills E. L. Szpyt J. He Z. Du G. Garrity R. Reddy A. Vaites L. P. Paulo J. A. Zhang T. Gray N. S. Gygi S. P. Chouchani E. T. Cell 2020 180 968-983 e924 PMC8164166 32109415
- Bar-Peled L. Kemper E. K. Suciu R. M. Vinogradova E. V. Backus K. M. Horning B. D. Paul T. A. Ichu T. A. Svensson R. U. Olucha J. Chang M. W. Kok B. P. Zhu Z. Ihle N. T. Dix M. M. Jiang P. Hayward M. M. Saez E. Shaw R. J. Cravatt B. F. Cell 2017 171 696-709 e623 PMC5728659 28965760
- Vinogradova E. V. Zhang X. Remillard D. Lazar D. C. Suciu R. M. Wang Y. Bianco G. Yamashita Y. Crowley V. M. Schafroth M. A. Yokoyama M. Konrad D. B. Lum K. M. Simon G. M. Kemper E. K. Lazear M. R. Yin S. Blewett M. M. Dix M. M. Nguyen N. Shokhirev M. N. Chin E. N. Lairson L. L. Melillo B. Schreiber S. L. Forli S. Teijaro J. R. Cravatt B. F. Cell 2020 182 1009-1026 e1029 PMC7775622 32730809
- Parker C. G. Galmozzi A. Wang Y. Correia B. E. Sasaki K. Joslyn C. M. Kim A. S. Cavallaro C. L. Lawrence R. M. Johnson S. R. Narvaiza I. Saez E. Cravatt B. F. Cell 2017 168 527-541 e529 PMC5632530 28111073
- Schwobel J. A. Wondrousch D. Koleva Y. K. Madden J. C. Cronin M. T. Schuurmann G. Chem. Res. Toxicol. 2010 23 1576 1585 20882991
- Tang B. He F. Liu D. Fang M. Wu Z. Xu D. bioRxiv 2020 10.1101/2020.03.03.972133 · DOI
- Authors
- Lu, W., Kostic, M., Zhang, T., Che, J., Patricelli, M. P., Jones, L. H., Chouchani, E. T., & Gray, N. S.
- Affiliations
- Harvard University (US)
- Department of Cancer Biology
- Vividion Therapeutics (United States) (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Gray, Nathanael S.
- ORCID
- Venue
- RSC Chemical Biology
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 2
- Issue
- 2
- Pages
- 354-367
- ISSN
- 2633-0679 (ISSN-L)
- PMC
- PMC8341086
- OpenAlex
- W3128963846
- Cited by
- 136
- References
- 121
- Citations by year
- 2026: 27 · 2025: 21 · 2024: 23 · 2023: 34 · 2022: 24 · 2021: 7
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-02-22)
- Open access
- gold
- doi.org
- Licence
- Locations
- RSC Chemical Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Keywords
- targeted covalent inhibitors, chemoproteomics, undruggable proteins, proteome-wide screening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
