Komatsu, Masaaki

Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells

Asano, T., Komatsu, M., Yamaguchi-Iwai, Y., Ishikawa, F., Mizushima, N., & Iwai, K. (2011) · Molecular and Cellular Biology

Iron Metabolism and DisordersAutophagy in Disease and Therapy

Cited by 265

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

Liu, Z., Chen, P., Gao, H., Gu, Y., Yang, J., Peng, H., Xu, X., Wang, H., Yang, M., Liu, X., et al. (2014) · Cancer Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 254

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury

Nakamura, S., Shigeyama, S., Minami, S., Shima, T., Akayama, S., Matsuda, T., Esposito, A., Napolitano, G., Kuma, A., Namba-Hamano, T., et al. (2020) · Nature Cell Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 235

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

Cadwell, K., Patel, K. K., Komatsu, M., Virgin, IV, & Stappenbeck, T. S. (2009) · Autophagy

Inflammatory Bowel DiseaseAutophagy in Disease and Therapy

Cited by 224

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

Onal, M., Piemontese, M., Xiong, J., Wang, Y., Han, L., Ye, S., Komatsu, M., Selig, M., Weinstein, R. S., Zhao, H., et al. (2013) · Journal of Biological Chemistry

Bone Metabolism and DiseasesAutophagy in Disease and Therapy

Cited by 206

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.

Tashiro, Y., Urushitani, M., Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., et al. (2012) · Journal of Biological Chemistry

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 194

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyPeroxisome Proliferator-Activated Receptors

Cited by 193

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

Lim, Y.-M., Lim, H., Hur, K. Y., Quan, W., Lee, H.-Y., Cheon, H., Ryu, D., Koo, S.-H., Kim, H. L., Kim, J., et al. (2014) · Nature Communications

Autophagy in Disease and TherapyAdipokines, Inflammation, and Metabolic Diseases

Cited by 189

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

Coupé, B., Ishii, Y., Dietrich, M. O., Komatsu, M., Horvath, T. L., & Bouret, S. G. (2012) · Cell Metabolism

Regulation of Appetite and ObesityAutophagy in Disease and Therapy

Cited by 174

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

Inoue, K., Rispoli, J., Kaphzan, H., Klann, E., Chen, E. I., Kim, J., Komatsu, M., & Abeliovich, A. (2012) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 168

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., & Hattori, N. (2018) · Scientific Reports

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 125

Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy

Muona, M., Ishimura, R., Laari, A., Ichimura, Y., Linnankivi, T., Keski-Filppula, R., Herva, R., Rantala, H., Paetau, A., Pöyhönen, M., et al. (2016) · The American Journal of Human Genetics

Ubiquitin and proteasome pathwaysGenetics and Neurodevelopmental Disorders

Cited by 119

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

Nam, S. A., Kim, W.-Y., Kim, J. W., Park, S. H., Kim, H. L., Lee, M.-S., Komatsu, M., Ha, H., Lim, J. H., Park, C. W., et al. (2019) · Cell Death & Disease

Autophagy in Disease and TherapyChronic Kidney Disease and Diabetes

Cited by 92

Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin

Donohue, E., Balgi, A. D., Komatsu, M., & Roberge, M. (2014) · PLoS ONE

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 79

Loss of autophagy promotes murine acetaminophen hepatotoxicity

Igusa, Y., Yamashina, S., Izumi, K., Inami, Y., Fukada, H., Komatsu, M., Tanaka, K., Ikejima, K., & Watanabe, S. (2012) · Journal of Gastroenterology

Drug-Induced Hepatotoxicity and ProtectionAutophagy in Disease and Therapy

Cited by 66

LC3B is indispensable for selective autophagy of p62 but not basal autophagy.

Maruyama, Y., Sou, Y.-S., Kageyama, S., Takahashi, T., Ueno, T., Tanaka, K., Komatsu, M., & Ichimura, Y. (2014) · Biochemical and Biophysical Research Communications

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 56

Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy

Ono, M., Komatsu, M., Ji, B., Takado, Y., Shimojo, M., Minamihisamatsu, T., Warabi, E., Yanagawa, T., Matsumoto, G., Aoki, I., et al. (2022) · Aging Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 45