Sviderskiy, Vladislav O.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature

Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism

Cited by 787

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours

Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X. G., Fidelin, J., Sviderskiy, V. O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C. A., et al. (2018) · Nature Cell Biology

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 442

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

Scott, D. C., Sviderskiy, V. O., Monda, J. K., Lydeard, J. R., Cho, S. E., Harper, J. W., & Schulman, B. A. (2014) · Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 201

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

Terzi, E. M., Sviderskiy, V. O., Alvarez, S. W., Whiten, G. C., & Possemato, R. (2021) · Science Advances

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 195

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

Sviderskiy, V. O., Blumenberg, L., Gorodetsky, E., Karakousi, T. R., Hirsh, N., Alvarez, S. W., Terzi, E. M., Kaparos, E., Whiten, G. C., Ssebyala, S., et al. (2020) · Molecular Cell

DNA Repair MechanismsBreast Cancer Treatment Studies

Cited by 56