Cited by 195Iron Metabolism and DisordersFerroptosis and cancer prognosisNeurological diseases and metabolism

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

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Terzi, Erdem M., Sviderskiy, Vladislav O., Alvarez, Samantha W., Whiten, Gabrielle C., Possemato, Richard·2021·Science Advances

Abstract

Iron-sulfur clusters enable cells to sense that they have the right amount of iron, and protect them from self-destruction.

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Crossref · 10.1126/sciadv.abg4302

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Authors
Terzi, E. M., Sviderskiy, V. O., Alvarez, S. W., Whiten, G. C., & Possemato, R.
Affiliations
NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
Corresponding author
Possemato, Richard
Venue
Science Advances
Published
2021-05-28
Volume
7
Issue
22
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3165555109
Cited by
195
References
34
Citations by year
2026: 35 · 2025: 49 · 2024: 47 · 2023: 36 · 2022: 20 · 2021: 8
FWCI
18.25
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (T32GM007308, T32GM115313, CA228202, CA168940, GM132491, CA198543, GM121994)
  • Alexander and Margaret Stewart Trust (N/A)
  • Friedreich’s Ataxia Research Alliance
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
IRP2, iron homeostasis, ferroptosis, iron regulatory protein 1, FBXL5, iron starvation response, iron-sulfur cluster assembly, Friedreich's ataxia, translational regulation, mRNA binding

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