Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5
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Iron-sulfur clusters enable cells to sense that they have the right amount of iron, and protect them from self-destruction.
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The importance of NFS1 and ISC stability in regulation of cancer cell sensitivity to ferroptosis has been demonstrated.
“Furthermore, the importance of NFS1 and ISC stability in regulation of cancer cell sensitivity to ferroptosis has also been demonstrated (30, 31).”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [31]
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- Authors
- Terzi, E. M., Sviderskiy, V. O., Alvarez, S. W., Whiten, G. C., & Possemato, R.
- Affiliations
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center (US)
- Corresponding author
- Possemato, Richard
- Venue
- Science Advances
- Published
- 2021-05-28
- Volume
- 7
- Issue
- 22
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC8153722
- OpenAlex
- W3165555109
- Cited by
- 195
- References
- 34
- Citations by year
- 2026: 35 · 2025: 49 · 2024: 47 · 2023: 36 · 2022: 20 · 2021: 8
- FWCI
- 18.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (T32GM007308, T32GM115313, CA228202, CA168940, GM132491, CA198543, GM121994)
- Alexander and Margaret Stewart Trust (N/A)
- Friedreich’s Ataxia Research Alliance
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- IRP2, iron homeostasis, ferroptosis, iron regulatory protein 1, FBXL5, iron starvation response, iron-sulfur cluster assembly, Friedreich's ataxia, translational regulation, mRNA binding
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