Heide, Danijela

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

Pfister, D., Núñez, N. G., Pinyol, R., Govaere, O., Pinter, M., Szydlowska, M., Gupta, R., Qiu, M., Deczkowska, A., Weiner, A., et al. (2021) · Nature

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

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Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 518

Cardiac glycosides are broad-spectrum senolytics

Guerrero, A., Herranz, N., Sun, B., Wagner, V., Gallage, S., Guiho, R., Wolter, K., Pombo, J., Irvine, E. E., Innes, A. J., et al. (2019) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 359

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Hoefflin, R., Harlander, S., Schäfer, S., Metzger, P., Kuo, F., Schönenberger, D., Adlesic, M., Peighambari, A., Seidel, P., Chen, C.-Y., et al. (2020) · Nature Communications

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 292

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

Georgilis, A., Klotz, S., Hanley, C. J., Herranz, N., Weirich, B., Morancho, B., Leote, A. C., D'Artista, L., Gallage, S., Seehawer, M., et al. (2018) · Cancer Cell

Telomeres, Telomerase, and SenescenceRNA Research and Splicing

Cited by 237

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Singhal, M., Gengenbacher, N., Abdul Pari, A. A., Kamiyama, M., Hai, L., Kuhn, B. J., Kallenberg, D. M., Kulkarni, S. R., Camilli, C., Preuß, S. F., et al. (2021) · Science Translational Medicine

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 80

Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling

Rosenberg, N., Van Haele, M., Lanton, T., Brashi, N., Bromberg, Z., Adler, H., Giladi, H., Peled, A., Goldenberg, D. S., Axelrod, J. H., et al. (2022) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 72

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

Funk, M. C., Gleixner, J. G., Heigwer, F., Valentini, E., Aydin, Z., Tonin, E., Hetzer, J., Heide, D., Stegle, O., Heikenwalder, M., et al. (2021) · Developmental Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 60

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity

Roehlen, N., Saviano, A., El Saghire, H., Crouchet, E., Nehme, Z., Del Zompo, F., Jühling, F., Oudot, M. A., Durand, S. C., Duong, F. H. T., et al. (2022) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 54

Ribosomal S6 kinase 1 regulates ‘inflammaging’ via the senescence secretome

Gallage, S., Irvine, E. E., Pedroni, S. M. A., Barragan Avila, J. E., Khadayate, S., Pombo, J., Brookes, S., Heide, D., Dharmalingham, G., Choudhury, A. I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 31

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J., Ibarra, I., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2024) · Nature Genetics

Liver physiology and pathologyPluripotent Stem Cells Research

Cited by 17