Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
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A temporal systems biology screen of premetastatic endothelial cells identified LRG1 as a therapeutic target for restricting metastases.
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The JAK-STAT pathway regulates metastasis and tumor angiogenesis.
“The JAK-STAT pathway is known to regulate metastasis and tumor angiogenesis35–37”
From Endothelial Pim3 kinase protects the vascular barrier during lung metastasis (2024) · cites this paper as [37]
The Introduction (page unavailable) says that deleting endothelial STAT3 suppressed metastatic colonization in mice, supporting a role for STAT3 signaling in metastasis. It does not establish that the JAK–STAT pathway regulates tumor angiogenesis; the Discussion (page unavailable) says LRG1 did not enhance lung endothelial-cell proliferation in this study and suggests the small metastases may have relied on vessel co-option rather than sprouting angiogenesis. (LLM, conf=0.87)
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- Authors
- Singhal, M., Gengenbacher, N., Abdul Pari, A. A., Kamiyama, M., Hai, L., Kuhn, B. J., Kallenberg, D. M., Kulkarni, S. R., Camilli, C., Preuß, S. F., Leuchs, B., Mogler, C., Espinet, E., Besemfelder, E., Heide, D., Heikenwalder, M., Sprick, M. R., Trumpp, A., Krijgsveld, J., Schlesner, M., Hu, J., Moss, S. E., Greenwood, J., & Augustin, H. G.
- Affiliations
- German Cancer Research Center (DE)
- Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.
- University College London (GB)
- Technical University of Munich (DE)
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
- University of Augsburg (DE)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Singhal, Mahak
- Gengenbacher, Nicolas
- Augustin, Hellmut G.
- ORCID
- Singhal, Mahak
- Gengenbacher, Nicolas
- Abdul Pari, Ashik Ahmed
- Kamiyama, Miki
- Kuhn, Bianca J.
- Kallenberg, David M.
- Kulkarni, Shubhada R.
- Camilli, Carlotta
- Preuß, Stephanie F.
- Leuchs, Barbara
- Mogler, Carolin
- Espinet, Elisa
- Heide, Danijela
- Heikenwalder, Mathias
- Sprick, Martin R.
- Trumpp, Andreas
- Krijgsveld, Jeroen
- Schlesner, Matthias
- Hu, Junhao
- Moss, Stephen E.
- Greenwood, John
- Augustin, Hellmut G.
- Venue
- Science Translational Medicine
- Published
- 2021-09
- Volume
- 13
- Issue
- 609
- Pages
- eabe6805-eabe6805
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7614902
- OpenAlex
- W3197197951
- Cited by
- 80
- References
- 68
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 26 · 2023: 17 · 2022: 12 · 2021: 3
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- Wellcome Trust (206413/B/17/Z, 206413/Z/17/Z)
- Medical Research Council (MR/N006410/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- LRG1, lung metastasis, tumor microenvironment, vascular niche, adjuvant therapy, therapeutic target
- MeSH terms
- Glycoproteins, Humans, Neoplasms
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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