McLean, W.H. Irwin

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 2,978

Filaggrin Mutations Associated with Skin and Allergic Diseases

Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine

Dermatology and Skin DiseasesSkin and Cellular Biology Research

Cited by 1,217

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y., & Williams, H. C. (2014) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesNeonatal skin health care

Cited by 722

Filaggrin in atopic dermatitis

O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 350

Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age: Filaggrin mutations, TEWL and eczema at 3 months

Flohr, C., England, K., Radulovic, S., McLean, W. H. I., Campbell, L. E., Barker, J., Perkin, M., & Lack, G. (2010) · British Journal of Dermatology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 251

RETRACTED: Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

Kelleher, M., Dunn-Galvin, A., Hourihane, J. O., Murray, D., Campbell, L. E., McLean, W. H. I., & Irvine, A. D. (2015) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 225

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y. A. E., Franke, A., Degenhardt, F., Lieb, W., et al. (2016) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesRheumatoid Arthritis Research and Therapies

Cited by 215

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., et al. (2015) · The American Journal of Human Genetics

Dermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 193

RETRACTED: Skin barrier impairment at birth predicts food allergy at 2 years of age

Kelleher, M. M., Dunn-Galvin, A., Gray, C., Murray, D. M., Kiely, M., Kenny, L., McLean, W. H. I., Irvine, A. D., & Hourihane, J. O. (2016) · Journal of Allergy and Clinical Immunology

Food Allergy and Anaphylaxis ResearchEosinophilic Esophagitis

Cited by 169

A mutation in the mucosal keratin K4 is associated with oral white sponge nevus

Rugg, E. L., McLean, W. H. I., Allison, W. E., Lunny, D. P., Macleod, R. I., Felix, D. H., Lane, E. B., & Munro, C. S. (1995) · Nature Genetics

Skin and Cellular Biology ResearchOral Health Pathology and Treatment

Cited by 148