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Cited by 215Dermatology and Skin DiseasesRheumatoid Arthritis Research and TherapiesGenetic Associations and Epidemiology

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

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Schmitt, Jochen, Schwarz, Kristin, Baurecht, Hansjörg, Hotze, Melanie, Fölster-Holst, Regina, Rodríguez, Elke, Lee, Young A.E., Franke, Andre +13 more·2016·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2015.06.029
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Abstract

Background Atopic dermatitis (AD) is characterized by epidermal barrier failure and immune-mediated inflammation. Evidence on AD as a potential risk factor for inflammatory comorbidities is scarce. Objectives We sought to test the hypothesis that prevalent AD is a risk factor for incident rheumatoid arthritis (RA) and inflammatory bowel disease (IBD; Crohn disease [CD], ulcerative colitis [UC]) and is inversely related to type 1 diabetes (T1D) and to investigate established RA, IBD, and T1D susceptibility loci in AD. Methods This cohort study used data from German National Health Insurance beneficiaries aged 40 years or younger (n = 655,815) from 2005 through 2011. Prevalent AD in the period 2005 to 2006 was defined as primary exposure, and incident RA, IBD, and T1D in the period 2007 to 2011 were defined as primary outcomes. Risk ratios were calculated with generalized linear models. Established RA, IBD, and T1D loci were explored in high-density genotyping data from 2,425 cases with AD and 5,449 controls. Results Patients with AD (n = 49,847) were at increased risk for incident RA (risk ratio [RR], 1.72; 95% CI, 1.25-2.37) and/or IBD (CD: RR, 1.34; 95% CI, 1.11-1.61; UC: RR, 1.25; 95% CI, 1.03-1.53). After adjusting for health care utilization, there was a nominally significant inverse effect on T1D risk (RR, 0.72; 95% CI, 0.53-0.998). There was no disproportionate occurrence of known RA, CD, UC, or T1D risk alleles in AD. Conclusions AD is a risk factor for the development of RA and IBD. This excess comorbidity cannot be attributed to major known IBD and RA genetic risk factors.

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  • These results suggest that overall genetic correlations may obscure a more complex set of genetic relationships at the level of specific loci and pathways.

    “These results underscore the complexity of genetic relationships among related disorders and suggest that overall genetic correlations may obscure a more complex set of genetic relationships at the level of specific loci and pathways, as seen in immune-mediated diseases (Baurecht et al., 2015; Lettre and Rioux, 2008; Schmitt et al., 2016).”

    From Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders (2019) · cites this paper as Schmitt et al., 2016

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Cited by

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Authors
Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y. A. E., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nöthen, M. M., Irvine, A. D., McLean, W. H. I., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N., & Weidinger, S.
Affiliations
  • Zentrum für Evidenzbasierte Gesundheitsversorgung (DE)
  • University Hospital Schleswig-Holstein (DE)
  • Max Delbrück Center (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Helmholtz Munich (DE)
  • University Hospital Regensburg (DE)
  • University of Bonn (DE)
  • Trinity College Dublin (IE)
  • University of Dundee (GB)
  • Technische Universität Dresden (DE)
Corresponding author
Schmitt, Jochen
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2016-01
Volume
137
Issue
1
Pages
130-136
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2015.06.029
OpenAlex
W1088236639
Cited by
215
References
4
Citations by year
2026: 5 · 2025: 19 · 2024: 15 · 2023: 31 · 2022: 19 · 2021: 30 · 2020: 21 · 2019: 25 · 2018: 10 · 2017: 20 · 2016: 16 · 2015: 3 · 2014: 1
FWCI
18.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
  • Site cant be reached (submittedVersion)
Funders
  • German Federal Ministry of Education and Research
  • PopGen 2.0 network (01EY1103)
  • German National Research Council
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
atopic dermatitis, rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, type 1 diabetes, comorbidity risk, genetic susceptibility loci, disease risk factors
MeSH terms
Adolescent, Adult, Arthritis, Rheumatoid, Child, Child, Preschool, Dermatitis, Atopic, Diabetes Mellitus, Type 1, Female, Germany, Humans, Infant, Infant, Newborn, Male, Risk Factors, Inflammatory Bowel Diseases, Incidence, Prevalence, Odds Ratio, Young Adult

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