Cummins, Eoin P.

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature

Immune Response and InflammationImmune cells in cancer

Cited by 4,176

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 788

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology

Inflammatory Bowel DiseaseMicroscopic Colitis

Cited by 407

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Scholz, C. C., Cavadas, M. A. S., Tambuwala, M. M., Hams, E., Rodríguez, J., Kriegsheim, A. V., Cotter, P., Bruning, U., Fallon, P. G., Cheong, A., et al. (2013) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 186

The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, C. T., & Cummins, E. P. (2009) · Annals of the New York Academy of Sciences

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 175

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

Hams, E., Saunders, S. P., Cummins, E. P., O'Connor, A., Tambuwala, M. T., Gallagher, W. M., Byrne, A., Campos-Torres, A., Moynagh, P. M., Jobin, C., et al. (2011) · Shock

Sepsis Diagnosis and TreatmentImmune Response and Inflammation

Cited by 106

Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia

Agbor, T. A., Cheong, A., Comerford, K. M., Scholz, C. C., Bruning, U., Clarke, A., Cummins, E. P., Cagney, G., & Taylor, C. T. (2011) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismUbiquitin and proteasome pathways

Cited by 68