The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, Cormac T.; Cummins, Eoin P.

doi:10.1111/j.1749-6632.2009.05024.x

Cited by 175NF-κB Signaling PathwaysCancer, Hypoxia, and MetabolismSignaling Pathways in Disease

The Role of NF‐κB in Hypoxia‐Induced Gene Expression

Taylor, Cormac T., Cummins, Eoin P.·2009·Annals of the New York Academy of Sciences

DOI 10.1111/j.1749-6632.2009.05024.x

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Abstract

Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen‐sensitive transcription factors including the hypoxia‐inducible factor (HIF) and nuclear factor‐kappaB (NF‐κB). Hypoxia‐dependent gene expression can have important physiologic or pathophysiologic consequences for an organism, depending upon the cause of the hypoxic insult. Consequently, this pathway represents an attractive therapeutic target in a number of disease states. While the mechanism linking hypoxia to the activation of HIF has been extensively studied, our understanding of how hypoxia activates NF‐κB is limited. Recent studies have demonstrated that similar oxygen‐sensing mechanisms are employed in conferring oxygen sensitivity to both HIF and NF‐κB−dependent gene expression. Furthermore, there is an extensive degree of cross‐talk occurring between NF‐κB and HIF. Investigations into mechanisms of hypoxic activation of HIF and NF‐κB and how these signaling pathways interact will uncover new therapeutic modalities in a diverse range of disease states where hypoxia is a feature of the microenvironment including cancer, vascular disease, and chronic inflammation.

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Hypoxia activates the NF-kB pathway through p65 and p50 stabilization and nuclear translocation that induces transcription of many genes.
“hypoxia activates the NF-kB pathway through p65 and p50 stabilization and nuclear translocation that induces transcription of many genes [54].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [54]

Shared Principles in NF-κB Signaling
Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,814 · see citing works
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519 · see citing works
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · see citing works
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,486 · see citing works
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433 · see citing works
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature · doi:10.1038/nature06905 · Cited by 1,614 · see citing works
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krähn, G. M., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S., et al. (2001) · Science · doi:10.1126/science.1062677 · Cited by 1,361 · see citing works
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942 · see citing works
Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891 · see citing works
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602235103 · Cited by 788 · see citing works
Self-citation
Activation of nuclear factor κB in inflammatory bowel disease
Schreiber, S., Nikolaus, S., & Hampe, J. (1998) · Gut · doi:10.1136/gut.42.4.477 · Cited by 752 · see citing works
Regulation of hypoxia-inducible factor-1α by NF-κB
van Uden, P., Kenneth, N. S., & Rocha, S. (2008) · Biochemical Journal · doi:10.1042/bj20080476 · Cited by 729 · see citing works
Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells
Schmedtje, J. F., Ji, Y.-S., Liu, W. L., DuBois, R. N., & Runge, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.601 · Cited by 668 · see citing works
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works
Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity
Doyle, S., & O'Neill, L. A. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.010 · Cited by 594 · see citing works
The NF-κB pathway
Moynagh, P. N. (2005) · Journal of Cell Science · doi:10.1242/jcs.02579 · Cited by 490 · see citing works
Hypoxia-responsive transcription factors
Cummins, E. P., & Taylor, C. T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1413-7 · Cited by 462 · see citing works
Self-citation
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.
Koong, A. C., Chen, E. Y., & Giaccia, A. J. (1994) · PubMed · Cited by 444 · see citing works
Hypoxia Up-Regulates Hypoxia-Inducible Factor-1α Transcription by Involving Phosphatidylinositol 3-Kinase and Nuclear Factor κB in Pulmonary Artery Smooth Muscle Cells
BelAiba, R. S., Bonello, S., Zähringer, C., Schmidt, S., Hess, J., Kietzmann, T., & Görlach, A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-04-0391 · Cited by 423 · see citing works
TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP
Han, Y.-P., Tuan, T., Wu, H., Hughes, M. W., & Garner, W. L. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.131 · Cited by 412 · see citing works
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
Cummins, E. P., Seeballuck, F., Keely, S. J., Mangan, N. E., Callanan, J. J., Fallon, P. G., & Taylor, C. T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.10.012 · Cited by 407 · see citing works
Self-citation
Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works
Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation
Taylor, C. T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.157669 · Cited by 354 · see citing works
Self-citation
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Fraisl, P., Aragonés, J., & Carmeliet, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2761 · Cited by 326 · see citing works
Hypoxia and gastrointestinal disease
Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313 · see citing works
Self-citation
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
Cockman, M. E., Lancaster, D. E., Stolze, I. P., Hewitson, K. S., McDonough, M. A., Coleman, M. L., Coles, C. H., Yu, X., Hay, R. T., Ley, S. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606877103 · Cited by 285 · see citing works
The IκB kinase – a bridge between inflammation and cancer
Karin, M. (2008) · Cell Research · doi:10.1038/cr.2008.30 · Cited by 260 · see citing works
Cytokine Gene Transcription By NF‐κB Family Members in Patients with Inflammatory Bowel Disease
Neurath, M. F., Fuss, I. J., Schürmann, G., Pettersson, S., ARNOLD, K., Müller-Lobeck, H., Strober, W., Herfarth, C. H., & Büschenfelde, K. M. Z. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb11119.x · Cited by 220 · see citing works
Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor α
Taylor, C. T., Dzus, A. L., & Colgan, S. P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70579-7 · Cited by 188 · see citing works
Self-citation
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes
Matsui, H. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00285-5 · Cited by 109 · see citing works
Hypoxia. Regulation of NFκB signalling during inflammation: the role of hydroxylases
Oliver, K. M., Taylor, C. T., & Cummins, E. P. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2575 · Cited by 91 · see citing works
Self-citation
Hypoxia induces macrophage inflammatory protein‐2 (MIP‐2) gene expression in murine macrophages via NF‐κB: the prominent role of p42/ p44 and PI3 kinase pathways
Zampetaki, A., Mitsialis, S. A., Pfeilschifter, J. M., & Kourembanas, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0991fje · Cited by 78 · see citing works
Targeting NF-κB: A Promising Molecular Therapy in Inflammatory Arthritis
Roman‐Blas, J. A., & Jiménez, S. A. (2008) · International Reviews of Immunology · doi:10.1080/08830180802295740 · Cited by 51 · see citing works
The IκB kinase- a bridge between inflammation and cancer
Michael, M., & Karin (2008) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 49 · see citing works
The Story of O 2
Kerr, R. A. (2005) · Science · doi:10.1126/science.308.5729.1730 · Cited by 40 · see citing works

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Rath, E., Moschetta, A., & Haller, D. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0021-x · Cited by 306 · see citing works
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Kvietys, P. R., & Granger, D. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.002 · Cited by 313 · see citing works
Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells
Colwell, N. A., Larion, M., Giles, A. J., Seldomridge, A. N., Sizdahkhani, S., Gilbert, M. R., & Park, D. M. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now258 · Cited by 287 · see citing works
Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies
Broekgaarden, M., Weijer, R., van Gulik, T. M., Hamblin, M. R., & Heger, M. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9588-7 · Cited by 261 · see citing works
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Strowitzki, M. J., Cummins, E. P., & Taylor, C. T. (2019) · Cells · doi:10.3390/cells8050384 · Cited by 248 · see citing works
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Fumagalli, S., Perego, C., Pischiutta, F., Zanier, E. R., & Simoni, M. G. D. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00081 · Cited by 245 · see citing works
The Involvement and Therapy Target of Immune Cells After Ischemic Stroke
Jian, Z., Liu, R., Zhu, X., Smerin, D., Zhong, Y., Gu, L., Fang, W., & Xiong, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02167 · Cited by 232 · see citing works
Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function
McNamee, E. N., Korns Johnson, D., Homann, D., & Clambey, E. T. (2013) · Immunologic Research · doi:10.1007/s12026-012-8349-8 · Cited by 234 · see citing works
Oxidative Stress and Blood–Brain Barrier Dysfunction Under Particular Consideration of Matrix Metalloproteinases
Lehner, C., Gehwolf, R., Tempfer, H., Krizbai, I. A., Hennig, B., Bauer, H., & Bauer, H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3923 · Cited by 231 · see citing works
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Chirico, E. N., & Pialoux, V. (2011) · IUBMB Life · doi:10.1002/iub.584 · Cited by 226 · see citing works
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Yeldag, G., Rice, A. J., & Hernández, A. E. D. R. (2018) · Cancers · doi:10.3390/cancers10120471 · Cited by 211 · see citing works
Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
D’Ignazio, L., Batie, M., & Rocha, S. (2017) · Biomedicines · doi:10.3390/biomedicines5020021 · Cited by 206 · see citing works
Interplay between DNA repair and inflammation, and the link to cancer
Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 186 · see citing works
IL-21 and T follicular helper cells
Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 182 · see citing works
The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
Bao, B., Azmi, A. S., Ali, S. S., Ahmad, A., Li, Y., Banerjee, S., Kong, D., & Sarkar, F. H. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.04.008 · Cited by 180 · see citing works
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The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens
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Regulation of Oxygen Homeostasis at the Intestinal Epithelial Barrier Site
Konjar, Š., Pavšič, M., & Veldhoen, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179170 · Cited by 58 · see citing works
Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells
Govaert, K. M., Emmink, B. L., Nijkamp, M. W., Cheung, Z. J., Steller, E. J. A., Fátrai, S., de Bruijn, M. T., Kranenburg, O., & Rinkes, I. H. M. B. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e318295c160 · Cited by 58 · see citing works
TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition
Raninga, P. V., Trapani, G. D., Vučković, S., & Tonissen, K. F. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1136038 · Cited by 58 · see citing works
An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling
Kominsky, D. J., Keely, S., MacManus, C. F., Glover, L. E., Scully, M. M., Collins, C. B., Bowers, B., Campbell, E. L., & Colgan, S. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002805 · Cited by 57 · see citing works
CaP-based anti-inflammatory HIF-1α siRNA-encapsulating nanoparticle for rheumatoid arthritis therapy
Liu, X., Guo, R., Huo, S., Chen, H., Song, Q., Jiang, G., Yu, Y., Huang, J., Xie, S., Gao, X., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.029 · Cited by 57 · see citing works
The Role of Hypoxia-Inducible Factors in Organ Donation and Transplantation: The Current Perspective and Future Opportunities
Akhtar, M. Z., Sutherland, A., Huang, H., Ploeg, R. J., & Pugh, C. W. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12737 · Cited by 56 · see citing works
Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer
Heymach, J. V., Shackleford, T. J., Tran, H. T., Yoo, S., Do, K.-A., Wergin, M., Saintigny, P., Vollmer, R. T., Polascik, T. J., Snyder, D. C., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0136 · Cited by 55 · see citing works
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases
Bhandari, T., & Nizet, V. (2014) · Infectious Diseases and Therapy · doi:10.1007/s40121-014-0030-1 · Cited by 53 · see citing works
The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages
Movahedi, K., & Ginderachter, J. A. V. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6704 · Cited by 53 · see citing works
VHL promotes immune response against renal cell carcinoma via NF-κB–dependent regulation of VCAM-1
Labrousse-Arias, D., Martínez‐Alonso, E., Corral-Escariz, M., Bienes-Martínez, R., Berridy, J., Serrano‐Oviedo, L., Conde, E., García‐Bermejo, L., Bachs, J. M. G., Sánchez, A. S. S., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201608024 · Cited by 53 · see citing works
Hypoxia in aquatic invertebrates: Occurrence and phenotypic and molecular responses
Lee, Y., Byeon, E., Kim, D., Maszczyk, P., Wang, M., Wu, R. S. S., Jeung, H.-D., Hwang, U.-K., & Lee, J. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106685 · Cited by 53 · see citing works
Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma
Yan, X., Zhou, M., Wang, J., Zhao, Y., Li, S., Zhou, B., Su, Z., Xu, C., Xia, Y., Qian, H., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.01.007 · Cited by 51 · see citing works
The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
Kang, B., Kleinhenz, J., Murphy, T. C., & Hart, C. M. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00195.2011 · Cited by 51 · see citing works
NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment
Rastogi, S., Aldosary, S., Saeedan, A. S., Ansari, M. N., Singh, M., & Kaithwas, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1108915 · Cited by 50 · see citing works
Mutually Supportive Mechanisms of Inflammation and Vascular Remodeling
Whiteford, J. R., Rossi, G. D., & Woodfin, A. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.05.001 · Cited by 47 · see citing works
Hypoxia-Inducible Factors as Key Players in the Pathogenesis of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
Holzner, L. M. W., & Murray, A. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.753268 · Cited by 44 · see citing works
Hydroxylases as therapeutic targets in inflammatory bowel disease
Cummins, E. P., Doherty, G. A., & Taylor, C. T. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.9 · Cited by 44 · see citing works
Self-citation
PlGF Immunological Impact during Pregnancy
Albonici, L., Benvenuto, M., Focaccetti, C., Cifaldi, L., Miele, M. T., Limana, F., Manzari, V., & Bei, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228714 · Cited by 44 · see citing works
Integrative transcriptome analysis and discovery of genes involving in immune response of hypoxia/thermal challenges in the small abalone Haliotis diversicolor
Zhang, X., Shi, J., Sun, Y., Habib, Y. J., Yang, H., Zhang, Z., & Wang, Y. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.044 · Cited by 44 · see citing works
Coagulation and Fibrinolysis in Obstructive Sleep Apnoea
Bikov, A., Mészáros, M., & Schwarz, E. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062834 · Cited by 41 · see citing works
Hypoxia and muscle maintenance regulation
de Theije, C. C., Costes, F., LANGEN, R. C. J., Pison, C. M., & Gosker, H. R. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834b6e79 · Cited by 40 · see citing works
Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A
Choi, S., Kim, M., Yoon, Y.-S., Koh, D., Kim, M.-K., Cho, S.-Y., Kim, K., & Hur, M. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.06.004 · Cited by 39 · see citing works
Semaphorin 7A Aggravates Pulmonary Inflammation during Lung Injury
Roth, J. M., Köhler, D., Schneider, M., Granja, T. F., & Rosenberger, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146930 · Cited by 39 · see citing works
HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells
Guan, Z., Ding, C., Du, Y., Zhang, K., Zhu, J., Zhang, T., He, D., Xu, S., Wang, X., & Fan, J. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2210 · Cited by 38 · see citing works
Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages
Chin, W.-Y., He, C.-Y., Chow, T. W., Yu, Q.-Y., Lai, L., & Miaw, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.630318 · Cited by 36 · see citing works
Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells
Adzigbli, L., Sokolov, E. P., Wimmers, K., Sokolova, I. M., & Ponsuksili, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-24386-0 · Cited by 38 · see citing works
Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis
Fraisl, P. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.02.010 · Cited by 37 · see citing works
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization
Gundemir, S., Colak, G., Feola, J., Blouin, R., & Johnson, G. V. W. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.011 · Cited by 37 · see citing works
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
Henríquez, J. A., Sleeman, J. P., & Garvalov, B. K. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9930-x · Cited by 37 · see citing works
Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling
Wang, G., Wang, J., Li, X., Wu, Q., Yao, R., & Luo, X. (2023) · Inflammation · doi:10.1007/s10753-022-01779-x · Cited by 37 · see citing works
Oxygen sensing in intestinal mucosal inflammation
Flück, K., & Fandrey, J. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1722-4 · Cited by 35 · see citing works
ROS‐ and HIF1α‐dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high‐glucose‐induced cardiomyocyte apoptosis
Huang, Y., Liu, C., Yang, Y., Aneja, R., Wen, S., Huang, C., & Kuo, W. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28034 · Cited by 36 · see citing works
Immunologic Consequences of Hypoxia during Critical Illness
Kiers, H. D., Scheffer, G., van der Hoeven, J. G., Eltzschig, H. K., Pickkers, P., & Kox, M. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001163 · Cited by 35 · see citing works
Endothelial differentiation of bone marrow mesenchyme stem cells applicable to hypoxia and increased migration through Akt and NFκB signals
Liu, C., Tsai, A.-L., Li, P.-C., Huang, C.-W., & Wu, C. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0470-0 · Cited by 35 · see citing works
Dynamic host immunity and PD-L1/PD-1 blockade efficacy: developments after “IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer”
Abiko, K., Hamanishi, J., Matsumura, N., & Mandai, M. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01960-x · Cited by 35 · see citing works
Impact of Short-Term Systemic Hypoxia on Phagocytosis, Cytokine Production, and Transcription Factor Activation in Peripheral Blood Cells
Fritzenwanger, M., Jung, C., Goebel, B., Lauten, A., & Figulla, H. R. (2011) · Mediators of Inflammation · doi:10.1155/2011/429501 · Cited by 35 · see citing works
Placental growth factor, vascular endothelial growth factor, and hypoxia-inducible factor-1α in the placentas of women with pre-eclampsia
Ali, L. E., Salih, M. M., Elhassan, E. M., Mohmmed, A. A., & Adam, I. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1443066 · Cited by 36 · see citing works
The Hepatocyte Growth Factor (HGF)/Met Axis: A Neglected Target in the Treatment of Chronic Myeloproliferative Neoplasms?
Boissinot, M., Vilaine, M., & Hermouet, S. (2014) · Cancers · doi:10.3390/cancers6031631 · Cited by 33 · see citing works
Obstructive sleep apnea syndrome: coagulation anomalies and treatment with continuous positive airway pressure
Toraldo, D. M., Benedetto, M. D., Scoditti, E., & Nuccio, F. D. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1227-6 · Cited by 33 · see citing works
Romance of the three kingdoms in hypoxia: HIFs, epigenetic regulators, and chromatin reprogramming
Chen, Y., Liu, M., Niu, Y.-L., & Wang, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.009 · Cited by 34 · see citing works
Impaired expression of hypoxia-inducible factor-1α in cystic fibrosis airway epithelial cells – A role for HIF-1 in the pathophysiology of CF?
Legendre, C., Mooij, M. J., Adams, C., & O’Gara, F. (2011) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2011.02.005 · Cited by 32 · see citing works
Deconvoluting the ontogeny of hematopoietic stem cells
Samokhvalov, I. M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1364-7 · Cited by 31 · see citing works
Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity
Vogel, J., Thiel, C. S., Tauber, S., Stockmann, C., Gassmann, M., & Ullrich, O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020436 · Cited by 30 · see citing works
Lactobacillus rhamnosus GG Ameliorates Liver Injury and Hypoxic Hepatitis in Rat Model of CLP-Induced Sepsis
Ding, L., Gong, Y., Yang, Z., Zou, B., Liu, X., Zhang, B., & Li, J. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05628-0 · Cited by 31 · see citing works
Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression
Ampofo, E., Berg, J. J., Menger, M. D., & Laschke, M. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-42465-7 · Cited by 27 · see citing works
Artificially Induced Epithelial-Mesenchymal Transition in Surgical Subjects: Its Implications in Clinical and Basic Cancer Research
Aoyagi, K., Minashi, K., Igaki, H., Tachimori, Y., Nishimura, T., Hokamura, N., Ashida, A., Daiko, H., Ochiai, A., Muto, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018196 · Cited by 27 · see citing works
Inhibition of NF-κB in Tumor Cells Exacerbates Immune Cell Activation Following Photodynamic Therapy
Broekgaarden, M., Kos, M., Jurg, F., van Beek, A. A., van Gulik, T. M., & Heger, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160819960 · Cited by 27 · see citing works
Significance of Tissue Expression and Serum Levels of Angiopoietin-like Protein 4 in Breast Cancer Progression: Link to NF-κB /P65 Activity and Pro-Inflammatory Cytokines
Shafik, N. M., Mohamed, D. A., Bedeer, A. E., & El-Gendy, A. M. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.18.8579 · Cited by 26 · see citing works
Minocycline alters expression of inflammatory markers in autonomic brain areas and ventilatory responses induced by acute hypoxia
Silva, T. M., Chaar, L. J. E., Silva, R. C., Takakura, A. C. T., Câmara, N. O. S., Antunes, V. R., & Moreira, T. S. (2018) · Experimental Physiology · doi:10.1113/ep086780 · Cited by 26 · see citing works

Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation
Taylor, C. T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.157669 · Cited by 354 · see citing works
Self-citation
An Intact Canonical NF-κB Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia
Fitzpatrick, S. F., Tambuwala, M. M., Brüning, U., Schaible, B., Scholz, C. C., Byrne, A. T., O’Connor, A. E., Gallagher, W. M., Lenihan, C. R., Garvey, J., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002256 · Cited by 153 · see citing works
Self-citation
NF-κB is a central regulator of hypoxia-induced gene expression
Shakir, D., Batie, M., Kwok, C.-S., Cook, S. J., Kenneth, N. S., & Rocha, S. (2025) · EMBO Reports · doi:10.1038/s44319-025-00651-x · Cited by 18 · see citing works
NFκB and HIF display synergistic behaviour during hypoxic inflammation
Brüning, U., Fitzpatrick, S. F., Frank, T. D., Birtwistle, M. R., Taylor, C. T., & Cheong, A. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0876-2 · Cited by 83 · see citing works
Self-citation
Mechanisms controlling transcription in hypoxia; an unexpected role of NF-κB
Shakir, D., Batie, M., & Rocha, S. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.03.030

Authors: Taylor, C. T., & Cummins, E. P.
Affiliations: University College Dublin (IE)
Corresponding author: Taylor, Cormac T.
ORCID: Taylor, Cormac T.
Cummins, Eoin P.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2009-10
Volume: 1177
Issue: 1
Pages: 178-184
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/j.1749-6632.2009.05024.x
OpenAlex: W2103214055
Cited by: 175
References: 35
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 6 · 2019: 13 · 2018: 11 · 2017: 10 · 2016: 15 · 2015: 15 · 2014: 17 · 2013: 16 · 2012: 15
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 14 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: NF-κB, hypoxia, hypoxia-inducible factor, oxygen sensing, transcriptional activation, gene expression regulation, therapeutic target, cancer, vascular disease, chronic inflammation, tumor microenvironment
MeSH terms: Animals, Hypoxia, Gene Expression Regulation, Humans, Models, Biological, NF-kappa B, Hypoxia-Inducible Factor 1

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The Role of NF‐κB in Hypoxia‐Induced Gene Expression

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