Newton, Alexandra C.

PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

Gao, T., Furnari, F., & Newton, A. C. (2005) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 906

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

Brognard, J., Sierecki, E., Gao, T., & Newton, A. C. (2007) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 591

Taxonomy and function of C1 protein kinase C homology domains

Hurley, J. H., Newton, A. C., Parker, P. J., Blumberg, P. M., & Nishizuka, Y. (1997) · Protein Science

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 362

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail.

Gould, C. M., Kannan, N., Taylor, S. S., & Newton, A. C. (2009) · Journal of Biological Chemistry

Heat shock proteins researchProtein Kinase Regulation and GTPase Signaling

Cited by 113

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

Alfonso, S. I., Callender, J. A., Hooli, B., Antal, C. E., Mullin, K., Sherman, M. A., Lesné, S. E., Leitges, M., Newton, A. C., Tanzi, R. E., et al. (2016) · Science Signaling

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 103

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

Hollands, A., Corriden, R., Gysler, G., Dahesh, S., Olson, J., Raza Ali, S., Kunkel, M. T., Lin, A. E., Forli, S., Newton, A. C., et al. (2016) · Journal of Biological Chemistry

Neutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Peptides and Activities

Cited by 73