Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895 · see citing works

Bootstrap methods: another look at the jackknife

Efron, B. (1979) · The Annals of Statistics · doi:10.1214/aos/1176344552 · Cited by 17,602 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

A simple method for organotypic cultures of nervous tissue

Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works

<i>TREM2</i> Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123 · see citing works

Trafficking and Proteolytic Processing of APP

Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075 · see citing works

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006338 · Cited by 1,000 · see citing works

Protein kinase C, an elusive therapeutic target?

Mochly‐Rosen, D., Das, K., & Grimes, K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3871 · Cited by 565 · see citing works

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

Violin, J. D., Zhang, J., Tsien, R. Y., & Newton, A. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302125 · Cited by 552 · see citing works

Protein kinase C: poised to signal

Newton, A. C. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00477.2009 · Cited by 520 · see citing works

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

Keranen, L. M., Sonnenburg, E. D., & Newton, A. C. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00277-6 · Cited by 470 · see citing works

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., et al. (2014) · Nature · doi:10.1038/nature12825 · Cited by 461 · see citing works

Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study

Driver, J. A., Beiser, A., Au, R., Kreger, B. E., Splansky, G. L., Kurth, T., Kiel, D. P., Lu, K. P., Seshadri, S., & Wolf, P. A. (2012) · BMJ · doi:10.1136/bmj.e1442 · Cited by 425 · see citing works

GEMINI: Integrative Exploration of Genetic Variation and Genome Annotations

Paila, U., Chapman, B., Kirchner, R., & Quinlan, A. R. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003153 · Cited by 423 · see citing works

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

Sonnenburg, E. D., Toker, A., & Newton, A. C. (1998) · Current Biology · doi:10.1016/s0960-9822(98)00017-7 · Cited by 381 · see citing works

Amyloid beta from axons and dendrites reduces local spine number and plasticity

Wei, W., Nguyen, L. N., Kessels, H. W., Hagiwara, H., Sisodia, S., & Malinow, R. (2010) · Nature Neuroscience · doi:10.1038/nn.2476 · Cited by 357 · see citing works

Results of a high-resolution genome screen of 437 Alzheimer's Disease families

Blacker, D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg007 · Cited by 344 · see citing works

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

Antal, C. E., Hudson, A., Kang, E., Zanca, C., Wirth, C., Stephenson, N. L., Trotter, E. W., Gallegos, L. L., Miller, C. J., Furnari, F. B., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.001 · Cited by 331 · see citing works

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

Pimplikar, S. W., Nixon, R. A., Robakis, N. K. R. K., Shen, J., & Tsai, L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4305-10.2010 · Cited by 281 · see citing works

Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-α

Staudinger, J. L., Lu, J., & Olson, E. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32019 · Cited by 254 · see citing works

Alzheimer disease and cancer

Roe, C. M., Behrens, M. I., Xiong, C., Miller, J. P., & Morris, J. C. (2005) · Neurology · doi:10.1212/01.wnl.0000152889.94785.51 · Cited by 225 · see citing works

Metabotropic NMDA receptor function is required for β-amyloid–induced synaptic depression

Kessels, H. W. H. G., Nabavi, S., & Malinow, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219605110 · Cited by 196 · see citing works

Targeting Protein Kinase C Activity Reporter to Discrete Intracellular Regions Reveals Spatiotemporal Differences in Agonist-dependent Signaling

Gallegos, L. L., Kunkel, M. T., & Newton, A. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603741200 · Cited by 186 · see citing works

Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

Creixell, P., Schoof, E. M., Simpson, C. D., Longden, J., Miller, C. J., Lou, H. J., Perryman, L., Cox, T. R., Zivanovic, N., Palmeri, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.056 · Cited by 175 · see citing works

In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation.

Sonnenburg, E. D., Keranen, L. M., DePaoli-Roach, A. A., & Newton, A. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43883-5 · Cited by 160 · see citing works

Knockout of PKCα Enhances Insulin Signaling Through PI3K

Letiges, M., Plomann, M., Standaert, M. L., Bandyopadhyay, G. K., Sajan, M. P., Kanoh, Y., & Farese, R. V. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.4.0809 · Cited by 158 · see citing works

Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease

Wilcox, K. C., Lacor, P. N., Pitt, J. E., & Klein, W. L. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9691-4 · Cited by 156 · see citing works

Alzheimer Disease in 2020Preprint

Holtzman, D. M., Mandelkow, E., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011585 · Cited by 151 · see citing works

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

Wagner, J., von Matt, P., Sedrani, R. C., Albert, R., Cooke, N. G., Ehrhardt, C., Geiser, M., Rummel, G., Stark, W., Strauss, A., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901108b · Cited by 132 · see citing works

A Unique PDZ Ligand in PKCα Confers Induction of Cerebellar Long-Term Synaptic Depression

Leitges, M., Kovac, J., Plomann, M., & Linden, D. J. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.024 · Cited by 123 · see citing works

Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC

Hoshi, N., Langeberg, L. K., Gould, C. M., Newton, A. C., & Scott, J. D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.014 · Cited by 110 · see citing works

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

Chen, C., Ha, B. H., Thévenin, A. F., Lou, H. J., Zhang, R., Yip, K. Y.-L., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.11.013 · Cited by 102 · see citing works

PKCγ mutations in spinocerebellar ataxia type 14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling

Verbeek, D. S., Goedhart, J., Bruinsma, L., Sinke, R. J., & Reits, E. A. (2008) · Journal of Cell Science · doi:10.1242/jcs.027698 · Cited by 87 · see citing works

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddu475 · Cited by 86 · see citing works

Alzheimer disease and cancer risk: a meta-analysis

Shi, H., Tang, B., Liu, Y.-W., Wang, X., & Chen, G. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1773-5 · Cited by 74 · see citing works

Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

Kinouchi, T., Sorimachi, H., Maruyama, K., Mizuno, K., Ohno, S., Ishiura, S., & Suzuki, K. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00392-m · Cited by 69 · see citing works

Protein Kinase Cα Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)

O’Neill, A., Gallegos, L. L., Justilien, V., Garcia, E. L., Leitges, M., Fields, A. P., Hall, R. A., & Newton, A. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294603 · Cited by 64 · see citing works

Intramolecular Conformational Changes Optimize Protein Kinase C Signaling

Antal, C. E., Violin, J. D., Kunkel, M. T., Skovsø, S., & Newton, A. C. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.02.008 · Cited by 64 · see citing works

Synapto‐depressive effects of amyloid beta require PICK 1

Alfonso, S., Kessels, H. W. H. G., Banos, C. C., Chan, T. R., Lin, E. Y.-S., Kumaravel, G., Scannevin, R. H., Rhodes, K. J., Huganir, R. L., Guckian, K. M., et al. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12499 · Cited by 62 · see citing works

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Antal, C. E., Callender, J. A., Kornev, A. P., Taylor, S. S., & Newton, A. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.039 · Cited by 61 · see citing works

Detecting Aβ*56 Oligomers in Brain Tissues

Sherman, M. A., & Lesné, S. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-744-0_4 · Cited by 35 · see citing works

Function and Dysfunction of Presenilin

Shen, J. (2013) · Neurodegenerative Diseases · doi:10.1159/000354971 · Cited by 32 · see citing works

Enhanced generation of Alzheimer’s amyloid‐β following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C

Silva, O. A. B. D. C. E., Rebelo, S., Vieira, S. I., Gandy, S., Silva, E. F. D. C. E., & Greengard, P. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05770.x · Cited by 32 · see citing works

Protein Kinase C‐Regulated Aβ Production and Clearance

Kim, T. H., Hinton, D. J., & Choi, D. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/857368 · Cited by 26 · see citing works

Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

Lane, R. F., Small, S. A., Gatson, J. W., Ehrlich, M. E., & Gandy, S. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-62 · Cited by 21 · see citing works

Alzheimer's disease

López, J. A., González, H. M., & Léger, G. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00013-3 · Cited by 834 · see citing works

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

Forner, S., Baglietto-Vargas, D., Martini, A. C., Trujillo-Estrada, L., & LaFerla, F. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.002 · Cited by 430 · see citing works

Protein kinase C: perfectly balanced

Newton, A. C. (2018) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2018.1442408 · Cited by 338 · see citing works

GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases

Chung, D., Shum, A. K., & Caraveo, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.567537 · Cited by 203 · see citing works

AGC kinases, mechanisms of regulation and innovative drug development

Leroux, A. E., Schulze, J. O., & Biondi, R. M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.05.011 · Cited by 155 · see citing works

Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

Reinders, N. R., Pao, Y., Renner, M., Matos, C. D. S., Lodder, T. R., Malinow, R., & Kessels, H. W. H. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614249113 · Cited by 126 · see citing works

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

Yao, H., Coppola, K., Schweig, J. E., Crawford, F., Mullan, M., & Paris, D. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00457 · Cited by 110 · see citing works

Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV

Wender, P. A., Hardman, C., Ho, S., Jeffreys, M. S., Maclaren, J. K., Quiroz, R. V., Ryckbosch, S. M., Shimizu, A., Sloane, J. L., & Stevens, M. C. (2017) · Science · doi:10.1126/science.aan7969 · Cited by 108 · see citing works

Protein kinase C as a tumor suppressor

Newton, A. C. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.017 · Cited by 106 · see citing works

Whole-genome sequencing reveals new Alzheimer’s disease–associated rare variants in loci related to synaptic function and neuronal development

Prokopenko, D., Morgan, S. L., Mullin, K., Hofmann, O., Chapman, B., Kirchner, R., (ADNI), A. D. N. I., Amberkar, S., Wohlers, I., Lange, C., et al. (2021) · Alzheimer's &amp; Dementia · doi:10.1002/alz.12319 · Cited by 107 · see citing works

Conventional protein kinase C in the brain: 40 years later

Callender, J. A., & Newton, A. C. (2017) · Neuronal Signaling · doi:10.1042/ns20160005 · Cited by 103 · see citing works

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor

Newton, A. C., & Brognard, J. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.02.002 · Cited by 100 · see citing works

A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration

Pellegrini, C., Pirazzini, C., Sala, C., Sambati, L., Yusipov, I., Kalyakulina, A., Ravaioli, F., Kwiatkowska, K. M., Durso, D. F., Ivanchenko, M., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.639428 · Cited by 88 · see citing works

Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's diseasePreprint

Xu, J., Zhang, P., Huang, Y., Zhou, Y., Hou, Y., Bekris, L. M., Lathia, J. D., Chiang, C., Li, L., Pieper, A. A., et al. (2021) · Genome Research · doi:10.1101/gr.272484.120 · Cited by 82 · see citing works

PTEN: Local and Global Modulation of Neuronal Function in Health and Disease

Knafo, S., & Esteban, J. A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2016.11.008 · Cited by 79 · see citing works

Diacylglycerol kinase control of protein kinase C

Mérida, I., Arranz‐Nicolás, J., Rodríguez‐Rodríguez, C., & Ávila‐Flores, A. (2019) · Biochemical Journal · doi:10.1042/bcj20180620 · Cited by 61 · see citing works

Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58 · see citing works

Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer’s disease

Morshed, N., Lee, M. J., Rodriguez, F. H., Lauffenburger, D. A., Mastroeni, D., & White, F. M. (2021) · Nature Aging · doi:10.1038/s43587-021-00071-1 · Cited by 58 · see citing works

Protein kinase C mechanisms that contribute to cardiac remodelling

Newton, A. C., Antal, C. E., & Steinberg, S. F. (2016) · Clinical Science · doi:10.1042/cs20160036 · Cited by 58 · see citing works

Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease

Ortiz-Sanz, C., Balantzategi, U., Quintela‐López, T., Ruiz, A., Luchena, C., Zuazo-Ibarra, J., Capetillo‐Zarate, E., Matute, C., Zugaza, J. L., & Alberdi, E. M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04687-y · Cited by 55 · see citing works

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes

Drange, O. K., Smeland, O. B., Shadrin, A. A., Finseth, P. I., Witoelar, A., & Frei, O. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00220 · Cited by 53 · see citing works

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Tomassoni‐Ardori, F., Fulgenzi, G., Becker, J., Barrick, C. A., Palko, M. E., Kuhn, S. A., Kopardé, V. N., Cam, M. C., Yanpallewar, S. U., Oberdoerffer, S., et al. (2019) · eLife · doi:10.7554/elife.49673 · Cited by 53 · see citing works

Altered translation elongation contributes to key hallmarks of aging in the killifish brain

Fraia, D. D., Marino, A., Lee, J. H., Sacramento, E. K., Baumgart, M., Bagnoli, S., Balla, T., Schalk, F., Kamrad, S., Guan, R., et al. (2025) · Science · doi:10.1126/science.adk3079 · Cited by 55 · see citing works

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Hardman, C., Ho, S., Shimizu, A., Luu-Nguyen, Q. H., Sloane, J. L., Soliman, M. S. A., Marsden, M. D., Zack, J. A., & Wender, P. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15742-7 · Cited by 49 · see citing works

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration

Morshed, N., Ralvenius, W. T., Nott, A., Watson, L. A., Rodriguez, F. H., Akay, L. A., Joughin, B. A., Pao, P., Penney, J., LaRocque, L. M., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209819 · Cited by 46 · see citing works

Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.

Russo, R., Cattaneo, F., Lippiello, P., Cristiano, C., Zurlo, F., Castaldo, M., Irace, C., Borsello, T., Santamaria, R., Ammendola, R., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.02.025 · Cited by 47 · see citing works

Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation

Callender, J. A., Yang, Y., Lordén, G., Stephenson, N. L., Jones, A. C., Brognard, J., & Newton, A. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805046115 · Cited by 44 · see citing works

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates‐Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. (2022) · Nature Communications · doi:10.1038/s41467-022-34679-7 · Cited by 41 · see citing works

Sex-specific DNA methylation: impact on human health and development

Govender, P., Ghai, M., & Okpeku, M. (2022) · Molecular Genetics and Genomics · doi:10.1007/s00438-022-01935-w · Cited by 42 · see citing works

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment

Yang, H., Staveness, D., Ryckbosch, S. M., Axtman, A. D., Loy, B. A., Barnes, A. B., Pande, V. S., Schaefer, J., Wender, P. A., & Cegelski, L. (2018) · ACS Central Science · doi:10.1021/acscentsci.7b00475 · Cited by 37 · see citing works

Protein Kinase C: Targets to Regenerate Brain Injuries?

Geribaldi‐Doldán, N., Gómez‐Oliva, R., Domínguez‐García, S., Nunez‐Abades, P., & Castro, C. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00039 · Cited by 37 · see citing works

Network-based identification of genetic factors in ageing, lifestyle and type 2 diabetes that influence to the progression of Alzheimer's disease

Chowdhury, U. N., Ahmad, S., Islam, M. B., Huq, F., Quinn, J. M. W., & Moni, M. A. (2020) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2020.100309 · Cited by 34 · see citing works

Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer

Sadeghi, M. M., Salama, M. F., & Hannun, Y. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115527 · Cited by 31 · see citing works

Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology

Fujita, K., Chen, X., Homma, H., Tagawa, K., Amano, M., Saito, A., Imoto, S., Akatsu, H., Hashizume, Y., Kaibuchi, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02821-z · Cited by 31 · see citing works

The key genes, phosphoproteins, processes, and pathways affected by efavirenz‐activated CYP46A1 in the amyloid‐decreasing paradigm of efavirenz treatment

Petrov, A. M., Mast, N., Li, Y., & Pikuleva, I. A. (2019) · The FASEB Journal · doi:10.1096/fj.201900092r · Cited by 31 · see citing works

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

Tanaka, H., Kondo, K., Fujita, K., Homma, H., Tagawa, K., Jin, X., Jin, M., Yoshioka, Y., Takayama, S., Masuda, H., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02671-4 · Cited by 31 · see citing works

PKCα and PKCδ: Friends and Rivals

Black, J. D., Affandi, T., Black, A. R., & Reyland, M. E. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102194 · Cited by 30 · see citing works

Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

Cooke, M., Casado‐Medrano, V., Ann, J., Lee, J., Blumberg, P. M., Abba, M. C., & Kazanietz, M. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-42581-4 · Cited by 28 · see citing works

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Lordén, G., & Newton, A. C. (2021) · Neuronal Signaling · doi:10.1042/ns20210036 · Cited by 27 · see citing works

Direct and Systemic Administration of a CNS-Permeant Tamoxifen Analog Reduces Amphetamine-Induced Dopamine Release and Reinforcing Effects

Carpenter, C., Zestos, A. G., Altshuler, R. D., Sorenson, R. J., Guptaroy, B., Showalter, H. D., Kennedy, R. T., Jutkiewicz, E. M., & Gnegy, M. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.95 · Cited by 27 · see citing works

A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells

Land, M., & Rubin, C. S. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-17 · Cited by 24 · see citing works

The role of PKC/PKR in aging, Alzheimer's disease, and perioperative neurocognitive disorders

Lü, W., Tang, S., Li, A., Huang, Q., Dou, M., Zhang, Y., Hu, X., Chang, R. C., Wong, G. T. C., & Huang, C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.973068 · Cited by 23 · see citing works

Profiling of Alzheimer’s disease related genes in mild to moderate vitamin D hypovitaminosis

Grimm, M. O. W., Lauer, A. A., Grösgen, S., Thiel, A., Lehmann, J., Winkler, J., Janitschke, D., Herr, C., Beißwenger, C., Bals, R., et al. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.01.015 · Cited by 22 · see citing works

Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster

Shim, K.-H., Kim, S.-H., Hur, J., Kim, D., Demirev, A. V., & Yoon, S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104519 · Cited by 22 · see citing works

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition

Pilo, C. A., Baffi, T. R., Kornev, A. P., Kunkel, M. T., Malfavon, M., Chen, D.-H., Rossitto, L.-A. M., Chen, D. X., Huang, L., Longman, C., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abk1147 · Cited by 21 · see citing works

Regulation of spermatid polarity by the actin- and microtubule (MT)-based cytoskeletons

Li, L., Mao, B., Wu, S., Lian, Q., Ge, R., Silvestrini, B., & Cheng, C. Y. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.01.013 · Cited by 20 · see citing works

TASK channels: channelopathies, trafficking, and receptor-mediated inhibition

Inoue, M., Matsuoka, H., Harada, K., Mugishima, G., & Kameyama, M. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02403-3 · Cited by 20 · see citing works

AhR/miR-23a-3p/PKCα axis contributes to memory deficits in ovariectomized and normal aging female mice

Zhang, S., An, X., Huang, S., Zeng, L., Xu, Y., Su, D., Qu, Y., Tang, X., Ma, J., Yang, J., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.02.015 · Cited by 20 · see citing works

Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes

Muraleedharan, A., Rotem‐Dai, N., Strominger, I., Anto, N. P., Isakov, N., Monsonego, A., & Livneh, E. (2020) · Glia · doi:10.1002/glia.23921 · Cited by 16 · see citing works

Putative role of natural products as Protein Kinase C modulator in different disease conditions

Singh, R. K., Kumar, S., Tomar, M. S., Verma, P. K., Kumar, A., Kumar, S., Kumar, N., Singh, J. P., & Acharya, A. (2021) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-021-00401-z · Cited by 17 · see citing works

Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging

Wu, J., Yarmey, V. R., Yang, O. J., Soderblom, E. J., San‐Miguel, A., & Yan, D. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01989-0 · Cited by 16 · see citing works

Mechanistic insight of the potential of geraniol against Alzheimer’s disease

Liu, Y., Zhou, S., Huang, X., & Rehman, H. M. (2022) · European journal of medical research · doi:10.1186/s40001-022-00699-8 · Cited by 14 · see citing works

Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development

Liu, D., Zinski, A. L., Mishra, A., Noh, H., Park, G.-H., Qin, Y., Olorife, O., Park, J. M., Abani, C. P., Park, J. S., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01654-z · Cited by 14 · see citing works

Impaired biogenesis of basic proteins impacts multiple hallmarks of the aging brainPreprint

Fraia, D. D., Marino, A., Lee, J. H., Sacramento, E. K., Baumgart, M., Bagnoli, S., da Silva, P. T., Sahu, A. K., Siano, G., Tiessen, M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549210 · Cited by 13 · see citing works

FAK-mediated signaling controls amyloid beta overload, learning and memory deficits in a mouse model of Alzheimer’s disease

Saleh, B., Srikanth, K. D., Sneh, T., Yue, L., Pelech, S., Elliott, E., & Gil-Henn, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169055 · Cited by 10 · see citing works

PKCα Isoform Inhibits Insulin Signaling and Aggravates Neuronal Insulin Resistance

Mishra, D., Reddy, I., & Dey, C. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03486-6 · Cited by 10 · see citing works

Cancer-associated mutations in protein kinase C theta are loss-of-function

Hodapp, S. J., Gravel, N., Kannan, N., & Newton, A. C. (2024) · Biochemical Journal · doi:10.1042/bcj20240148 · Cited by 10 · see citing works

Amyloid-β-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors

Reinders, N. R., van der Spek, S. J. F., Klaassen, R. V., Koymans, K. J., MacGillavry, H. D., Smit, A. B., & Kessels, H. W. H. G. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0393-24.2024 · Cited by 9 · see citing works

Exploring the efficient natural products for Alzheimer’s disease therapy via Drosophila melanogaster (fruit fly) models

Wu, M., Li, Y., Miao, Y., Qiao, H., & Wang, Y. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2245582 · Cited by 9 · see citing works

The α1-adrenergic receptors in the amygdala regulate the induction of learned despair through protein kinase C-beta signaling

Fujita, S., Yoshida, S., Matsuki, T., Jaiswal, M. K., & Seki, K. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000605 · Cited by 9 · see citing works

Brain phosphoproteomic analysis identifies diabetes‐related substrates in Alzheimer's disease pathology in older adults

Capuano, A., Sarsani, V., Tasaki, S., Mehta, R. I., Li, J., Ahima, R., Arnold, S., Bennett, D. A., Petyuk, V., Liang, L.-M., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.14460 · Cited by 9 · see citing works

Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord

Balantzategi, U., Gaminde‐Blasco, A., Kearns, C. A., Bayón‐Cordero, L., Sánchez‐Gómez, M. V., Zugaza, J. L., Appel, B., & Alberdi, E. M. (2025) · Glia · doi:10.1002/glia.70015 · Cited by 8 · see citing works

PKCα: Prospects in Regulating Insulin Resistance and AD

Mishra, D., & Dey, C. S. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.03.006 · Cited by 9 · see citing works

PKC in Regenerative Therapy: New Insights for Old Targets

Rui, M., Nasti, R., Bignardi, E., Volpe, S. D., Rossino, G., Rossi, D., & Collina, S. (2017) · Pharmaceuticals · doi:10.3390/ph10020046 · Cited by 8 · see citing works

Rapid screening of active ingredients and action mechanisms of Ecliptae Herba for treating Alzheimer's disease by UPLC-Q-TOF/MS and “component-target-pathway” network

Wei, J., Wang, Y., Wang, X., Zhang, Y., Zheng, Y., Shao, J., Cheng, W., & Li, Y. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105613 · Cited by 7 · see citing works

The KLDpT activation loop motif is critical for MARK kinase activity

Sonntag, T., Moresco, J. J., Yates, J. R., & Montminy, M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0225727 · Cited by 7 · see citing works

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

Mosna, S., & Dormann, D. (2025) · BioEssays · doi:10.1002/bies.70084 · Cited by 6 · see citing works

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Jones, A. C., Kornev, A. P., Weng, J., Manning, G., Taylor, S. S., & Newton, A. C. (2023) · Biochemical Journal · doi:10.1042/bcj20220397 · Cited by 6 · see citing works

Network-based analysis on the genes and their interactions reveals link between schizophrenia and Alzheimer's disease

Guo, P., Meng, C., Zhang, S., Cai, Y., Huang, J., Shu, J., Wang, J., & Cai, C. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109802 · Cited by 6 · see citing works

Gene co-expression changes underlying the functional connectomic alterations in Alzheimer’s disease

He, B., Gorijala, P., Xie, L., Cao, S., & Yan, J. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01244-6 · Cited by 6 · see citing works

Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03463-9 · Cited by 6 · see citing works

Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis

Jin, M., Jin, X., Homma, H., Fujita, K., Tanaka, H., Murayama, S., Akatsu, H., Tagawa, K., & Okazawa, H. (2021) · Communications Biology · doi:10.1038/s42003-021-02475-6 · Cited by 5 · see citing works

Uncovering active ingredients and mechanisms of Pholiota adiposa in the treatment of Alzheimer’s disease based on network pharmacology and bioinformatics

Ma, X., Zhiming, H., Mingwen, S., Hong, W., Tao, Y., Jun, X., & Gong, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-94861-x · Cited by 5 · see citing works

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease

Gaurón, M. C., Prokopenko, D., Lee, S., Wolfe, S. A., Hecker, J., Willett, J., Waqas, M., Lordén, G., Yang, Y., Mayfield, J. E., et al. (2025) · Science Signaling · doi:10.1126/scisignal.adv0970 · Cited by 7 · see citing works

A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

Chen, X., Dixit, K., Yang, Y., McDermott, M. I., Imam, H. T., Bankaitis, V. A., & Igumenova, T. I. (2024) · eLife · doi:10.7554/elife.92884 · Cited by 4 · see citing works

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

Do, A. N., Song, S., Ali, M., Timsina, J., Wang, L., Western, D., Liu, M., Sanford, J., Rosende-Roca, M., Boada, M., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71063 · Cited by 4 · see citing works

Elevated CSF GAP-43 in Mild Cognitive Impairment Linked to Cognitive Impairment Through Increased Amyloid-β Accumulation, with a Shift to Reduced Amyloid-β Accumulation in Alzheimer’s Disease

Azargoonjahromi, A., Eivazi, M., Nasiri, H., Tarhriz, V., Payandeh, Z., & Initiative, A. D. N. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02333-8 · Cited by 2 · see citing works

C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases

Hodapp, S. J., Kao, T. H., Wu, J., Balasuriya, N., Antal, C. E., Taylor, S. S., & Newton, A. C. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110921 · Cited by 2 · see citing works

Lithium chloride alters Tau phosphorylation, kinase activity, and Rho GTPase signaling in cell models

Hoffmann, D. B., Ahola, V., Huber, N., Natunen, T., Leskelä, S., Takalo, M., Martiskainen, H., Ballweg, S., Vorontsov, E. A., Selzer, S., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119347 · Cited by 1 · see citing works

Synapse engineering: A new level of brain modulation

Chen, Y., & Geng, Y. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.003 · Cited by 1 · see citing works

How can cancer research be illuminated by brain research (and vice versa)?

Mentis, A. A., Papavassiliou, K. A., Piperi, C., & Papavassiliou, A. G. (2023) · International Journal of Cancer · doi:10.1002/ijc.34682 · Cited by 1 · see citing works

Paul Greengard, Ph.D. (1925‐2019)

Gandy, S., & Suzuki, T. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.08.001 · Cited by 1 · see citing works

Atypical Protein Kinase C Hyperactivity in Insulin-Resistant and Insulin-Sensitive Forms of Alzheimer’s Disease: A Potential Therapeutic Target

Farese, R. V., Kindy, M. S., & Sajan, M. P. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch6 · Cited by 1 · see citing works

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease

Newton, A. C., Tanzi, R. E., & VanHook, A. M. (2016) · Science Signaling · doi:10.1126/scisignal.aaf9436

FRETting over postsynaptic PKC signaling

Dell’Acqua, M. L., & Woolfrey, K. M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0190-5

Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing AutoinhibitionPreprint

Pilo, C. A., Baffi, T. R., Kornev, A. P., Kunkel, M. T., Malfavon, M., Chen, D., Huang, L., Longman, C., Kannan, N., Raskind, W. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.24.449810

Protein Kinase C (Prkc)

Newton, A. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101822

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

Mira, H., Díez del Corral, R., & Morales, A. V. (2020) · Frontiers research topics · doi:10.3389/978-2-88963-988-5

Protein Kinase C (Prkc)

Newton, A. C. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101822-1

Editorial expression of concern

Foley, J. F. (2022) · Science Signaling · doi:10.1126/scisignal.add4323

PRKCA and TCF4 Genetic Variants in Anxiety Symptoms and Generalized Anxiety Disorder in a Sample of Colombian Subjects Selected on the Basis of High Anxiety Scores

Rodríguez, D., Montes, L. U., Quiñones, B. J., Zamora, S., Moreno, L., Villamil, W., González‐Giraldo, Y., Báez, S., Forero, D. A., & Trujillo‐Güiza, M. L. (2023) · The Open Psychology Journal · doi:10.2174/0118743501266432231122062610 · Cited by 1 · see citing works

Additional file 1 of Mechanistic insight of the potential of geraniol against Alzheimer’s disease

Liu, Y., Zhou, S., Huang, X., & Rehman, H. M. (2022) · Figshare · doi:10.6084/m9.figshare.20070019

Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490464

Amyloid β oligomers dysregulate oligodendrocyte differentiation and myelination via PKC in the zebrafish spinal cordPreprint

Balantzategi, U., Gaminde‐Blasco, A., Bayón‐Cordero, L., Sánchez‐Gómez, M. V., Zugaza, J. L., Appel, B., & Alberdi, E. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.10.598246

Screening of a kinase inhibitor library in human Huntington’s disease iPSC-derived striatal precursor neurons reveals a neuroprotective effect of PKC-α/β1 inhibitionPreprint

Jiang, M., Shi, T., Miryala, R., Rodriguez, M., Wang, R. S., Sultania, R., Guttman, L. C., Johnston, J., Mulligan, L., Li, Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.18.677178

Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer’s Disease

Astorino, M. F., Cipriano, G. L., Anchesi, I., Lui, M., Raffaele, I., Calabrò, M., & Crisafulli, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199816

Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461

Additional file 2 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098424

Additional file 1 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098421

Additional file 3 of Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice

Yang, J., Yang, N., Zhao, H., Qiao, Y., Li, Y., Wang, C., Lim, K., Zhang, C., Yang, W., & Lu, L. (2023) · Figshare · doi:10.6084/m9.figshare.24098427

A role for PKC in Alzheimer's disease

Ferrarelli, L. K. (2016) · Science · doi:10.1126/science.352.6287.783-r

The Role of PICK1 and PKC alpha in Alzheimer’s Disease

Alfonso, S. (2016) · eScholarship (California Digital Library)

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Lordén, G., Wozniak, J. M., Doré, K., Dozier, L. E., Cates‐Gatto, C., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., Tanzi, R. E., & Newton, A. C. (2022) · Nature Communications · doi:10.1038/s41467-022-34679-7 · Cited by 41 · see citing works

Amplified Protein Kinase C Signaling in Alzheimer's Disease

Lordén, G., Wosniak, J. M., Dozier, L. E., Patrick, G. N., Gonzalez, D. J., Roberts, A. J., & Newton, A. C. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.06842 · Cited by 2 · see citing works

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer’s disease

Newton, A. C., Tanzi, R. E., & VanHook, A. M. (2016) · Science Signaling · doi:10.1126/scisignal.aaf9436