Lewin, Alfred S.

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

Mitter, S. K., Song, C., Qi, X., Mao, H., Rao, H., Akin, D., Lewin, A., Grant, M., Dunn, W., Ding, J., et al. (2014) · Autophagy

Autophagy in Disease and TherapyRetinal Diseases and Treatments

Cited by 449

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

Petrs-Silva, H., Dinculescu, A., Li, Q., Min, S.-H., Chiodo, V., Pang, J.-J., Zhong, L., Zolotukhin, S., Srivastava, A., Lewin, A. S., et al. (2009) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 398

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

Petrs-Silva, H., Dinculescu, A., Li, Q., Deng, W.-T., Pang, J.-J., Min, S.-H., Chiodo, V., Neeley, A. W., Govindasamy, L., Bennett, A., et al. (2011) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 267

A comprehensive review of retinal gene therapy

Boye, S. E., Boye, S. L., Lewin, A. S., & Hauswirth, W. W. (2013) · Molecular Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 262

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

Beltran, W. A., Cideciyan, A. V., Lewin, A. S., Iwabe, S., Khanna, H., Sumaroka, A., Chiodo, V. A., Fajardo, D. S., Román, A. J., Deng, W.-T., et al. (2012) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersVirus-based gene therapy research

Cited by 260

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

Brown, E. E., DeWeerd, A. J., Ildefonso, C. J., Lewin, A. S., & Ash, J. D. (2019) · Redox Biology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 259

SOD2 knockdown mouse model of early AMD

Justilien, V., Pang, J.-J., Renganathan, K., Zhan, X., Crabb, J. W., Kim, S. R., Sparrow, J. R., Hauswirth, W. W., & Lewin, A. S. (2007) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 234

Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Long-term survival and late-stage therapy

LaVail, M. M., Yasumura, D., Matthes, M. T., Drenser, K. A., Flannery, J. G., Lewin, A. S., & Hauswirth, W. W. (2000) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRNA Interference and Gene Delivery

Cited by 203

Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector

Cideciyan, A. V., Sudharsan, R., Dufour, V. L., Massengill, M. T., Iwabe, S., Swider, M., Lisi, B., Sumaroka, A., Marinho, L. F., Appelbaum, T., et al. (2018) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersVirus-based gene therapy research

Cited by 147

Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside

Rowe-Rendleman, C. L., Durazo, S. A., Kompella, U. B., Rittenhouse, K. D., Di Polo, A., Weiner, A. L., Grossniklaus, H. E., Naash, M. I., Lewin, A. S., Horsager, A., et al. (2014) · Investigative Opthalmology & Visual Science

Advanced Drug Delivery SystemsRetinal Diseases and Treatments

Cited by 120

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

Song, C., Mitter, S. K., Qi, X., Beli, E., Rao, H. V., Ding, J., Ip, C. S., Gu, H., Akin, D., Dunn, W. A., et al. (2017) · PLoS ONE

Retinal Diseases and TreatmentsAutophagy in Disease and Therapy

Cited by 100

rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters

Beltran, W. A., Boye, S. L., Boye, S. E., Chiodo, V. A., Lewin, A. S., Hauswirth, W. W., & Aguirre, G. D. (2010) · Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 96

LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile

Koilkonda, R., Yu, H., Talla, V., Porciatti, V., Feuer, W. J., Hauswirth, W. W., Chiodo, V., Erger, K. E., Boye, S. L., Lewin, A. S., et al. (2014) · Investigative Ophthalmology & Visual Science

Retinal Development and DisordersVirus-based gene therapy research

Cited by 65

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium.

Seo, S.-J., Krebs, M. P., Mao, H., Jones, K., Conners, M., & Lewin, A. S. (2012) · Experimental Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 51

Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding

Gorbatyuk, O. S., Warrington, K. H., Gorbatyuk, M. S., Zolotukhin, I., Lewin, A. S., & Muzyczka, N. (2019) · Virus Research

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 18

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Massengill, M. T., Ash, N. F., Young, B. M., Ildefonso, C. J., & Lewin, A. S. (2020) · Scientific Reports

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 13