Giacomini, Kathleen M.

Membrane transporters in drug development

The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 3,340

SLC Transporters as Therapeutic Targets: Emerging Opportunities

Lin, L., Yee, S. W., Kim, R. B., & Giacomini, K. M. (2015) · Nature Reviews Drug Discovery

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 835

Metformin pathways: pharmacokinetics and pharmacodynamics

Gong, L., Goswami, S., Giacomini, K. M., Altman, R. B., & Klein, T. E. (2012) · Pharmacogenetics and Genomics

Pharmacogenetics and Drug MetabolismMetabolism, Diabetes, and Cancer

Cited by 495

Genetics of P450 oxidoreductase: Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations

Huang, N., Agrawal, V., Giacomini, K. M., & Miller, W. L. (2008) · Proceedings of the National Academy of Sciences

Pharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

Cited by 198

Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes

Glatt, C. E., DeYoung, J. A., Delgado, S., Service, S. K., Giacomini, K. M., Edwards, R. H., Risch, N., & Freimer, N. B. (2001) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 154

Artificial intelligence, ChatGPT, and other large language models for social determinants of health: Current state and future directions

Ong, J. C. L., Seng, B. J. J., Law, J. Z. F., Low, L. L., Kwa, A. L. H., Giacomini, K. M., & Ting, D. S. W. (2024) · Cell Reports Medicine

Artificial Intelligence in Healthcare and EducationEthics and Social Impacts of AI

Cited by 111

Consequences of POR mutations and polymorphisms

Miller, W. L., Agrawal, V., Sandee, D., Tee, M. K., Huang, N., Choi, J. H., Morrissey, K., & Giacomini, K. M. (2011) · Molecular and Cellular Endocrinology

Pharmacogenetics and Drug MetabolismSexual Differentiation and Disorders

Cited by 88

Opportunities and challenges for the computational interpretation of rare variation in clinically important genes

McInnes, G., Sharo, A. G., Koleske, M. L., Brown, J. E. H., Norstad, M., Adhikari, A. N., Wang, S., Brenner, S. E., Halpern, J., Koenig, B. A., et al. (2021) · The American Journal of Human Genetics

Genomics and Rare DiseasesArtificial Intelligence in Healthcare and Education

Cited by 86

Highlights from the International Transporter Consortium Second Workshop

Zamek-Gliszczynski, M. J., Hoffmaster, K. A., Tweedie, D. J., Giacomini, K. M., & Hillgren, K. M. (2012) · Clinical Pharmacology & Therapeutics

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 82

Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro

Sandee, D., Morrissey, K., Agrawal, V., Tam, H. K., Kramer, M. A., Tracy, T. S., Giacomini, K. M., & Miller, W. L. (2010) · Pharmacogenetics and Genomics

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 74

Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells

Chien, H.-C., Zur, A. A., Maurer, T. S., Yee, S. W., Tolsma, J., Jasper, P., Scott, D. O., & Giacomini, K. M. (2016) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 63

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

Zou, L., Spanogiannopoulos, P., Pieper, L. M., Chien, H.-C., Cai, W., Khuri, N., Pottel, J., Vora, B., Ni, Z., Tsakalozou, E., et al. (2020) · Proceedings of the National Academy of Sciences

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 61

Genetic variation in human P450 oxidoreductase

Miller, W. L., Huang, N., Agrawal, V., & Giacomini, K. M. (2009) · Molecular and Cellular Endocrinology

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 54

Structural and molecular basis of choline uptake into the brain by FLVCR2

Cater, R. J., Mukherjee, D., Gil-Iturbe, E., Erramilli, S. K., Chen, T., Koo, K., Santander, N., Reckers, A., Kloss, B., Gawda, T., et al. (2024) · Nature

Drug Transport and Resistance MechanismsBarrier Structure and Function Studies

Cited by 45

Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response

Brackman, D. J., & Giacomini, K. M. (2018) · Clinical Pharmacology & Therapeutics

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 31

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates

Yee, S. W., Ferrández-Peral, L., Alentorn-Moron, P., Fontsere, C., Ceylan, M., Koleske, M. L., Handin, N., Artegoitia, V. M., Lara, G., Chien, H.-C., et al. (2024) · Nature Communications

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 4

Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates

Giacomini, K., Yee, S. W., Ferrández-Peral, L., Alentorn, P., Fontsere, C., Ceylan, M., Koleske, M., Handin, N., Artegoitia, V., Lara, G., et al. (2023) · Research Square

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 1