Will, Yvonne

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

Dykens, J. A., Jamieson, J., Marroquin, L., Nadanaciva, S., Billis, P. A., & Will, Y. (2008) · Toxicology and Applied Pharmacology

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 220

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Aleo, M. D., Luo, Y., Swiss, R., Bonin, P. D., Potter, D. M., & Will, Y. (2014) · Hepatology

Drug-Induced Hepatotoxicity and ProtectionDrug Transport and Resistance Mechanisms

Cited by 215

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays

Shah, F., Leung, L., Barton, H. A., Will, Y., Rodrigues, A. D., Greene, N., & Aleo, M. D. (2015) · Toxicological Sciences

Drug-Induced Hepatotoxicity and ProtectionAnimal testing and alternatives

Cited by 148

Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications

Fabre, K., Berridge, B., Proctor, W. R., Ralston, S., Will, Y., Baran, S. W., Yoder, G., & Van Vleet, T. R. (2020) · Lab on a Chip

3D Printing in Biomedical ResearchAnimal testing and alternatives

Cited by 116

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity

Dykens, J. A., Marroquin, L. D., & Will, Y. (2007) · Expert Review of Molecular Diagnostics

Mitochondrial Function and PathologyDrug-Induced Hepatotoxicity and Protection

Cited by 95