Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications
Abstract
Opportunities in the drug discovery/development process for potential MPS incorporation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The IQ MPS affiliate has provided guidelines for qualifying new models for specific contexts of use to help advance regulatory acceptance and broader industrial adoption.
“Recognizing the promise of MPS for drug research and development, the IQ MPS affiliate has provided guidelines for qualifying new models for specific contexts of use to help advance regulatory acceptance and broader industrial adoption18”
From Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology (2022) · cites this paper as [18]
The IQ guidelines for assessment of an in vitro liver MPS within the DILI prediction context of use require evidence that the model replicates key histological structures and functions of the liver and can distinguish between 7 pairs of small-molecule toxic drugs and their non-toxic structural analogs; if it passes, it must demonstrate ability to predict the clinical responses of 6 additional-seed
“The IQ guidelines for assessment of an in vitro liver MPS within the DILI prediction context of use requires evidence that the model replicates key histological structures and functions of the liver; furthermore, the model must be able to distinguish between 7 pairs of small-molecule toxic drugs and their non-toxic structural analogs. If the model passes through these hurdles, it must demonstrate”
From Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology (2022) · cites this paper as [18]
Cites
Concordance of the toxicity of pharmaceuticals in humans and in animals
Olson, H., Betton, G., Robinson, D., Thomas, K., Monro, A., Kolaja, G., Lilly, P., Sanders, J., Sipes, G., Bracken, W., et al. (2000) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.2000.1399 · Cited by 2,050 · see citing works
Phase II and Phase III attrition rates 2011–2012
Arrowsmith, J., & Miller, P. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4090 · Cited by 697 · see citing works
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
Proctor, W. R., Foster, A. J., Vogt, J., Summers, C., Middleton, B., Pilling, M. A., Shienson, D., Kijanska, M., Ströbel, S., Kelm, J. M., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2002-1 · Cited by 328 · see citing works
Self-citationGrassart, A., Malardé, V., Gobaa, S., Sartori-Rupp, A., Kerns, J., Karalis, K., Marteyn, B., Sansonetti, P., & Sauvonnet, N. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.007 · Cited by 206 · see citing works
Monticello, T. M., Jones, T. W., Dambach, D. M., Potter, D. M., Bolt, M. W., Liu, M., Keller, D. A., Hart, T. K., & Kadambi, V. J. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.09.006 · Cited by 186 · see citing works
Guidance of stem cell fate on 2D patterned surfaces
Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.070 · Cited by 163 · see citing works
Baudy, A. R., Otieno, M. A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T. R., & Proctor, W. R. (2020) · Lab on a Chip · doi:10.1039/c9lc00768g · Cited by 150 · see citing works
Self-citationTamaki, C., Nagayama, T., Hashiba, M., Fujiyoshi, M., Hizue, M., Kodaira, H., Nishida, M., Suzuki, K., Takashima, Y., Ogino, Y., et al. (2013) · The Journal of Toxicological Sciences · doi:10.2131/jts.38.581 · Cited by 79 · see citing works
Ainslie, G. R., Davis, M., Ewart, L., Lieberman, L. A., Rowlands, D. J., Thorley, A. J., Yoder, G., & Ryan, A. M. (2019) · Lab on a Chip · doi:10.1039/c9lc00492k · Cited by 65 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Human organs-on-chips for disease modelling, drug development and personalized medicine
Ingber, D. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00466-9 · Cited by 1,589 · see citing works
A guide to the organ-on-a-chip
Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116 · see citing works
Organs-on-chips: into the next decade
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029 · see citing works
Self-citationPerformance assessment and economic analysis of a human Liver-Chip for predictive toxicology
Ewart, L., Apostolou, A., Briggs, S. A., Carman, C. V., Chaff, J. T., Heng, A. R., Jadalannagari, S., Janardhanan, J., Jang, K.-J., Joshipura, S. R., et al. (2022) · Communications Medicine · doi:10.1038/s43856-022-00209-1 · Cited by 337 · see citing works
Standardisation needs for organ on chip devices
Piergiovanni, M., Leite, S. B., Corvi, R., & Whelan, M. (2021) · Lab on a Chip · doi:10.1039/d1lc00241d · Cited by 155 · see citing works
Towards in vitro models for reducing or replacing the use of animals in drug testing
Stresser, D. M., Kopec, A. K., Hewitt, P., Hardwick, R. N., Van Vleet, T. R., Mahalingaiah, P. K. S., O’Connell, D., Jenkins, G. J., David, R., Graham, J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01154-7 · Cited by 94 · see citing works
Self-citationMicrophysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium
Rusyn, I., Sakolish, C., Kato, Y., Stephan, C., Vergara, L., Hewitt, P., Bhaskaran, V., Davis, M., Hardwick, R. N., Ferguson, S. S., et al. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac061 · Cited by 43 · see citing works
Tomlinson, L., Ramsden, D., Leite, S. B., Beken, S., Bonzo, J. A., Brown, P., Candarlioglu, P. L., Chan, T. S., Chen, E., Choi, C. K., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202300131 · Cited by 33 · see citing works
Self-citation
- Authors
- Fabre, K., Berridge, B., Proctor, W. R., Ralston, S., Will, Y., Baran, S. W., Yoder, G., & Van Vleet, T. R.
- Affiliations
- Translational Research Institute (AU)
- National Institute of Environmental Health Sciences (US)
- Genentech (US)
- AbbVie (United States) (US)
- Discovery, Product Development & Supply
- Novartis (Switzerland) (CH)
- Janssen Research & Development (United States) (US)
- Department of Preclinical Safety
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 20
- Issue
- 6
- Pages
- 1049-1057
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W3005321388
- Cited by
- 116
- References
- 9
- Citations by year
- 2026: 14 · 2025: 17 · 2024: 23 · 2023: 18 · 2022: 18 · 2021: 23 · 2020: 3
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- microphysiological systems, organotypic models, drug safety assessment, ADME, toxicology, organ-on-a-chip, biologics, drug disposition, animal-to-human translation
- MeSH terms
- Animals, Blood-Brain Barrier, Pharmaceutical Preparations, Humans, Kidney, Liver, Lung
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
