Parsons, Ramon

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell

Cancer-related Molecular PathwaysCell death mechanisms and regulation

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PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 4,785

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Tamura, M., Gu, J., Matsumoto, K., Aota, S.-I., Parsons, R., & Yamada, K. M. (1998) · Science

Cell Adhesion Molecules ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 1,215

PTEN function: the long and the short of it

Hopkins, B. D., Hodakoski, C., Barrows, D., Mense, S. M., & Parsons, R. E. (2014) · Trends in Biochemical Sciences

PI3K/AKT/mTOR signaling in cancerProtein Tyrosine Phosphatases

Cited by 309

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system

Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., et al. (2025) · Nature Materials

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

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PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

Mathur, D., Stratikopoulos, E., Ozturk, S., Steinbach, N., Pegno, S., Schoenfeld, S., Yong, R., Murty, V. V., Asara, J. M., Cantley, L. C., et al. (2017) · Cancer Discovery

Biochemical and Molecular ResearchCancer, Hypoxia, and Metabolism

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Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma

Molina-Sánchez, P., Ruiz de Galarreta, M., Yao, M. A., Lindblad, K. E., Bresnahan, E., Bitterman, E., Martin, T. C., Rubenstein, T., Nie, K., Golas, J., et al. (2020) · Gastroenterology

Hepatocellular Carcinoma Treatment and PrognosisCancer Genomics and Diagnostics

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Acetylation targeting chimera enables acetylation of the tumor suppressor p53

Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R., et al. (2023) · Journal of the American Chemical Society

Protein Degradation and InhibitorsChemical Synthesis and Analysis

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Design, synthesis, and evaluation of p53Y220C acetylation targeting chimeras (AceTACs)

Hu, X., Kabir, M., Lin, Y., Xiong, Y., Parsons, R. E., Gu, W., & Jin, J. (2024) · Journal of Medicinal Chemistry

Cancer-related Molecular PathwaysProtein Degradation and Inhibitors

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