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Cited by 309PI3K/AKT/mTOR signaling in cancerProtein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

PTEN function: the long and the short of it

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Hopkins, Benjamin D., Hodakoski, Cindy, Barrows, Douglas, Mense, Sarah M., Parsons, Ramon E.·2014·Trends in Biochemical Sciences
DOI 10.1016/j.tibs.2014.02.006PMC PMC4043120
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Abstract

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that is frequently altered in cancer. PTEN has phosphatase-dependent and -independent roles, and genetic alterations in PTEN lead to deregulation of protein synthesis, the cell cycle, migration, growth, DNA repair, and survival signaling. PTEN localization, stability, conformation, and phosphatase activity are controlled by an array of protein-protein interactions and post-translational modifications. Thus, PTEN-interacting and -modifying proteins have profound effects on the tumor suppressive functions of PTEN. Moreover, recent studies identified mechanisms by which PTEN can exit cells, via either exosomal export or secretion, and act on neighboring cells. This review focuses on modes of PTEN protein regulation and ways in which perturbations in this regulation may lead to disease.

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  • PTEN is commonly mutated in wide ranges of GBM, which may be a candidate for therapeutic intervention.

    “A tumour suppressor gene, like phosphatase and tensin homologue (PTEN), is commonly mutated in wide ranges of GBM, which may be a great candidate for therapeutic intervention27,54.”

    From Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system (2025) · cites this paper as [54]

    The ‘Importance of PTEN function and regulation’ section (page not provided) identifies PTEN as a tumour suppressor frequently lost in cancers including brain tumours and reports mutations across many tumour types. It does not establish how commonly PTEN is mutated specifically in GBM or identify it as a therapeutic candidate for GBM. (LLM, conf=0.85)

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  1. [1]Li J PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer Science 1997 275 1943 1947 9072974
  2. [2]Steck PA Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers Nature genetics 1997 15 356 362 9090379
  3. [3]Gao J Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal Science signaling 2013 6 pl1 23550210 PMC4160307
  4. [5]Li DM Sun H TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta Cancer research 1997 57 2124 2129 9187108
  5. [6]Myers MP The lipid phosphatase activity of PTEN is critical for its tumor supressor function Proceedings of the National Academy of Sciences of the United States of America 1998 95 13513 13518 9811831 PMC24850
  6. [7]Maehama T Dixon JE The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate The Journal of biological chemistry 1998 273 13375 13378 9593664
  7. [8]Stambolic V Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN Cell 1998 95 29 39 9778245
  8. [9]Leslie NR PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration Current biology: CB 2007 17 115 125 17240336 PMC1885949
  9. [10]Raftopoulou M Regulation of cell migration by the C2 domain of the tumor suppressor PTEN Science 2004 303 1179 1181 14976311
  10. [11]Dey N The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration Cancer research 2008 68 1862 1871 18339867
  11. [12]Tamura M Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN Science 1998 280 1614 1617 9616126
  12. [14]Cully M Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis Nature reviews. Cancer 2006 6 184 192 16453012
  13. [15]Mayo LD Donner DB The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network Trends in biochemical sciences 2002 27 462 467 12217521
  14. [16]Alimonti A Subtle variations in Pten dose determine cancer susceptibility Nature genetics 2010 42 454 458 20400965 PMC3118559
  15. [17]Shen-Li H Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice Cancer biology & therapy 2010 10 1194 1200 20980828 PMC3018670
  16. [18]Liaw D Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome Nature genetics 1997 16 64 67 9140396
  17. [19]Arch EM Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease American journal of medical genetics 1997 71 489 493 9286463
  18. [20]Zhou X Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes Lancet 2001 358 210 211 11476841
  19. [21]Marsh DJ Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation Genes, chromosomes & cancer 1998 21 61 69 9443042
  20. [22]Zhou XP Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults American journal of human genetics 2003 73 1191 1198 14566704 PMC1180498
  21. [23]Butler MG Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations Journal of medical genetics 2005 42 318 321 15805158 PMC1736032
  22. [24]Hollander MC PTEN loss in the continuum of common cancers, rare syndromes and mouse models Nature reviews. Cancer 2011 11 289 301 PMC6946181 21430697
  23. [25]Trimboli AJ Pten in stromal fibroblasts suppresses mammary epithelial tumours Nature 2009 461 1084 1091 19847259 PMC2767301
  24. [26]Tibarewal P PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity Science signaling 2012 5 ra18 22375056
  25. [27]Lee JO Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Cell 1999 99 323 334 10555148
  26. [28]Walker SM The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif The Biochemical journal 2004 379 301 307 14711368 PMC1224073
  27. [29]Campbell RB Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate The Journal of biological chemistry 2003 278 33617 33620 12857747
  28. [30]Vazquez F Phosphorylation of the PTEN tail regulates protein stability and function Molecular and cellular biology 2000 20 5010 5018 10866658 PMC85951
  29. [31]Lee SR Reversible inactivation of the tumor suppressor PTEN by H2O2 The Journal of biological chemistry 2002 277 20336 20342 11916965
  30. [32]Silva A PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability The Journal of clinical investigation 2008 118 3762 3774 18830414 PMC2556239
  31. [33]Okumura K PCAF modulates PTEN activity The Journal of biological chemistry 2006 281 26562 26568 16829519
  32. [34]Ikenoue T PTEN acetylation modulates its interaction with PDZ domain Cancer research 2008 68 6908 6912 18757404
  33. [35]Wang X NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN Cell 2007 128 129 139 17218260 PMC1828909
  34. [37]Fouladkou F The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization Proceedings of the National Academy of Sciences of the United States of America 2008 105 8585 8590 18562292 PMC2438405
  35. [38]Drinjakovic J E3 ligase Nedd4 promotes axon branching by downregulating PTEN Neuron 2010 65 341 357 20159448 PMC2862300
  36. [39]Van Themsche C X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization The Journal of biological chemistry 2009 284 20462 20466 19473982 PMC2742810
  37. [40]Maddika S WWP2 is an E3 ubiquitin ligase for PTEN Nature cell biology 2011 13 728 733 PMC3926303 21532586
  38. [41]Lee JT RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation Cell research 2013 23 552 564 23419514 PMC3616435
  39. [42]Maccario H Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress The Journal of biological chemistry 2010 285 12620 12628 20177066 PMC2857106
  40. [43]Huang J SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane Nature communications 2012 3 911 22713753
  41. [44]Bassi C Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress Science 2013 341 395 399 23888040 PMC5087104
  42. [45]Miller SJ Direct identification of PTEN phosphorylation sites FEBS letters 2002 528 145 153 12297295
  43. [46]Torres J Pulido R The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation The Journal of biological chemistry 2001 276 993 998 11035045
  44. [47]Al-Khouri AM Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta The Journal of biological chemistry 2005 280 35195 35202 16107342
  45. [48]Koul D Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity Oncogene 2002 21 2357 2364 11948419
  46. [49]Lu Y Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades The Journal of biological chemistry 2003 278 40057 40066 12869565
  47. [50]Li Z Regulation of PTEN by Rho small GTPases Nature cell biology 2005 7 399 404 15793569
  48. [51]Yim EK Rak functions as a tumor suppressor by regulating PTEN protein stability and function Cancer cell 2009 15 304 314 19345329 PMC2673492
  49. [52]Maccario H PTEN is destabilized by phosphorylation on Thr366 The Biochemical journal 2007 405 439 444 17444818 PMC2267318
  50. [53]Odriozola L Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain The Journal of biological chemistry 2007 282 23306 23315 17565999
  51. [54]Zhang XC Functional analysis of the protein phosphatase activity of PTEN The Biochemical journal 2012 444 457 464 22413754 PMC3365644
  52. [55]Rahdar M A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN Proceedings of the National Academy of Sciences of the United States of America 2009 106 480 485 19114656 PMC2626728
  53. [56]Tolkacheva T Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383 Cancer research 2001 61 4985 4989 11431330
  54. [57]Vazquez F Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex The Journal of biological chemistry 2001 276 48627 48630 11707428
  55. [58]Okumura K Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor Proceedings of the National Academy of Sciences of the United States of America 2005 102 2703 2706 15659546 PMC549467
  56. [59]Torres J Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions The Journal of biological chemistry 2003 278 30652 30660 12788938
  57. [60]Ning K A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells The EMBO journal 2006 25 2377 2387 16675953 PMC1478173
  58. [61]Moult PR Leptin regulates AMPA receptor trafficking via PTEN inhibition The Journal of neuroscience: the official journal of the Society for Neuroscience 2010 30 4088 4101 20237279 PMC2843829
  59. [62]Patsoukis N PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2 Molecular and cellular biology 2013 33 3091 3098 23732914 PMC3753920
  60. [63]Yang Z Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation Clinics and research in hepatology and gastroenterology 2013 37 72 79 22521126
  61. [64]Vo K Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation Molecular cancer 2011 10 138 22074495 PMC3253061
  62. [66]Lima-Fernandes E Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins The EMBO journal 2011 30 2557 2568 21642958 PMC3155309
  63. [67]Wu X Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 Proceedings of the National Academy of Sciences of the United States of America 2000 97 4233 4238 10760291 PMC18208
  64. [68]Wu Y Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase The Journal of biological chemistry 2000 275 21477 21485 10748157
  65. [69]Kotelevets L Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2005 19 115 117 15629897
  66. [70]Takahashi Y PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling The EMBO journal 2006 25 910 920 16456542 PMC1383560
  67. [71]Chagpar RB Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase Proceedings of the National Academy of Sciences of the United States of America 2010 107 5471 5476 20212113 PMC2851819
  68. [72]Cheung LW High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability Cancer discovery 2011 1 170 185 21984976 PMC3187555
  69. [73]Sumitomo M Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN Cancer cell 2004 5 67 78 14749127
  70. [74]Fine B Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a Science 2009 325 1261 1265 19729658 PMC2936784
  71. [75]Hodakoski C Regulation of PTEN Inhibition by the pleckstrin homology domain of PREX2 during insulin signaling and glucose homeostasis Proceedings of the National Academy of Sciences of the United States of America 2014 IN PRESS PMC3890808 24367090
  72. [76]Berger MF Melanoma genome sequencing reveals frequent PREX2 mutations Nature 2012 485 502 506 22622578 PMC3367798
  73. [77]Ikeda F SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis Nature 2011 471 637 641 21455181 PMC3085511
  74. [78]He L Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells The Journal of clinical investigation 2010 120 2094 2108 20458142 PMC2877943
  75. [79]Wang L Suzuki T Dual functions for cytosolic alpha-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its alpha-mannosidase activity The Journal of biological chemistry 2013 288 11887 11896 23486476 PMC3636876
  76. [80]Yue W Suppression of 6A8 alpha-mannosidase gene expression reduced the potentiality of growth and metastasis of human nasopharyngeal carcinoma International journal of cancer. Journal international du cancer 2004 108 189 195 14639601
  77. [81]Tian Y Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis Cancer science 2008 99 2428 2434 19018777 PMC11158925
  78. [82]Xiang ZG hMan2c1 transgene promotes tumor progress in mice Transgenic research 2010 19 67 75 19572206
  79. [83]He L alpha-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells Nature communications 2011 2 307 21556061
  80. [84]Song MS Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner Cell 2011 144 187 199 21241890 PMC3249980
  81. [85]Putz U The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells Science signaling 2012 5 ra70 23012657
  82. [86]Hopkins BD A secreted PTEN phosphatase that enters cells to alter signaling and survival Science 2013 341 399 402 23744781 PMC3935617
  83. [87]Malaney P The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy Molecular bioSystems 2013 9 2877 2888 24056727
  84. [88]Mistafa O Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases The Journal of biological chemistry 2010 285 27900 27910 20605778 PMC2934657
  85. [89]Lin HK Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells Mol Endocrinol 2004 18 2409 2423 15205473
  86. [90]Fan C PTEN inhibits BMI1 function independently of its phosphatase activity Molecular cancer 2009 8 98 19903340 PMC2777864
  87. [91]Crockett DK Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics Proteomics 2005 5 1250 1262 15717329
  88. [92]Caselli A Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1 Biochemical and biophysical research communications 2002 296 692 697 12176037
  89. [93]Shen WH Essential role for nuclear PTEN in maintaining chromosomal integrity Cell 2007 128 157 170 17218262
  90. [94]Sotelo NS A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains Journal of cellular biochemistry 2012 113 2661 2670 22434720
  91. [95]Adey NB Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding Cancer research 2000 60 35 37 10646847
  92. [96]Lu D Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression Gastroenterology 2011 140 2084 2094 21354147 PMC3109169
  93. [97]Gorbenko O Identification of novel PTEN-binding partners: PTEN interaction with fatty acid binding protein FABP4 Molecular and cellular biochemistry 2010 337 299 305 19911253
  94. [98]Yang C PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha Molecular cancer 2013 12 21 23514585 PMC3610140
  95. [99]Okahara F Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein The Journal of biological chemistry 2004 279 45300 45303 15355975
  96. [100]Jurado S PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression The EMBO journal 2010 29 2827 2840 20628354 PMC2924645
  97. [101]Gunaratne J Protein interactions of phosphatase and tensin homologue (PTEN) and its cancer-associated G20E mutant compared by using stable isotope labeling by amino acids in cell culture-based parallel affinity purification The Journal of biological chemistry 2011 286 18093 18103 21454687 PMC3093882
  98. [102]Valiente M Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases The Journal of biological chemistry 2005 280 28936 28943 15951562
  99. [103]Lin MC PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity The Biochemical journal 2012 441 367 377 21883094
  100. [104]Yu Z PTEN associates with the vault particles in HeLa cells The Journal of biological chemistry 2002 277 40247 40252 12177006
  101. [105]van Diepen MT MyosinV controls PTEN function and neuronal cell size Nature cell biology 2009 11 1191 1196 PMC2756284 19767745
  102. [106]Howitt J Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia The Journal of cell biology 2012 196 29 36 22213801 PMC3255971
  103. [107]Mund T Pelham HR Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 Proceedings of the National Academy of Sciences of the United States of America 2010 107 11429 11434 20534535 PMC2895104
  104. [108]von Stein W Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling Development 2005 132 1675 1686 15743877
  105. [109]Mahimainathan L Choudhury GG Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase The Journal of biological chemistry 2004 279 15258 15268 14718524
  106. [110]Cao J Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity The EMBO journal 2009 28 1505 1517 19369943 PMC2688529
  107. [111]Haier J Nicolson GL PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow Oncogene 2002 21 1450 1460 11857088
  108. [112]Tamura M PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway The Journal of biological chemistry 1999 274 20693 20703 10400703
  109. [113]Kim YJ PTEN modulates miR-21 processing via RNA-regulatory protein RNH1 PloS one 2011 6 e28308 22162762 PMC3230587
  110. [114]Sanchez T PTEN as an effector in the signaling of antimigratory G protein-coupled receptor Proceedings of the National Academy of Sciences of the United States of America 2005 102 4312 4317 15764699 PMC555509
  111. [115]Yang L Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) is required for the estradiol-dependent increase of phosphatase and tensin homolog (PTEN) protein expression Endocrinology 2011 152 4537 4549 21990315
  112. [116]Hjelmeland AB Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity Cancer research 2005 65 11276 11281 16357132
  113. [117]Mehenni H LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes Human molecular genetics 2005 14 2209 2219 15987703
  114. [118]Ahmed SF The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation The Journal of biological chemistry 2012 287 15996 16006 22427670 PMC3346122
  115. [119]Gonzalez-Santamaria J Regulation of the tumor suppressor PTEN by SUMO Cell death & disease 2012 3 e393 23013792 PMC3461367
  116. [120]Herlevsen M A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer Biochemical and biophysical research communications 2007 352 549 555 17126809 PMC1933505
  117. [121]Freeman DJ PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms Cancer cell 2003 3 117 130 12620407
  118. [122]Zhou M PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells Cancer research 2003 63 6357 6362 14559824
  119. [123]Meuillet EJ Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity Archives of biochemistry and biophysics 2004 429 123 133 15313215

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Authors
Hopkins, B. D., Hodakoski, C., Barrows, D., Mense, S. M., & Parsons, R. E.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Parsons, Ramon E.
ORCID
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2014-04
Volume
39
Issue
4
Pages
183-190
ISSN
0968-0004 (ISSN-L)
DOI
10.1016/j.tibs.2014.02.006
PMC
PMC4043120
OpenAlex
W2109559424
Cited by
309
References
125
Citations by year
2026: 13 · 2025: 26 · 2024: 29 · 2023: 21 · 2022: 24 · 2021: 35 · 2020: 36 · 2019: 32 · 2018: 22 · 2017: 22 · 2016: 13 · 2015: 25 · 2014: 11
FWCI
2.23
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Biochemical Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (P01CA097403, R01CA082783, R01CA155117, R01CA184016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
PTEN, phosphatase and tensin homolog, tumor suppressor, phosphatase activity, protein-protein interaction, post-translational modification, protein stability, cancer, cell cycle regulation, DNA repair, cell migration
MeSH terms
Animals, Cell Cycle, Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Genomic Instability, PTEN Phosphohydrolase

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