Engen, John R.

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

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Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor

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Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

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Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

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Tissue-Specific Oncogenic Activity of KRASA146T

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Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7.

Lamberto, I., Liu, X., Seo, H.-S., Schauer, N. J., Iacob, R. E., Hu, W., Das, D., Mikhailova, T., Weisberg, E. L., Engen, J. R., et al. (2017) · Cell Chemical Biology

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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.

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The natural product cucurbitacin E inhibits depolymerization of actin filaments

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Allosteric inhibition of antiapoptotic MCL-1

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