Vaux, David L.

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Vaux, D. L. (2000) · Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 2,372

Error bars in experimental biology

Cumming, G., Fidler, F., & Vaux, D. L. (2007) · The Journal of Cell Biology

Data Visualization and AnalyticsAcademic Writing and Publishing

Cited by 940

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

Kroemer, G., El-Deiry, W. S., Golstein, P., Peter, M. E., Vaux, D., Vandenabeele, P., Zhivotovsky, B., Blagosklonny, M. V., Malorni, W., Knight, R. A., et al. (2005) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 843

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

Delbridge, A. R. D., Grabow, S., Strasser, A., & Vaux, D. L. (2016) · Nature Reviews Cancer

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 752

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Marsden, V. S., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) · Nature

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 578

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Conos, S. A., Chen, K. W., De Nardo, D., Hara, H., Whitehead, L., Núñez, G., Masters, S. L., Murphy, J. M., Schroder, K., Vaux, D. L., et al. (2017) · Proceedings of the National Academy of Sciences

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 485

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

Linke, K., Mace, P. D., Smith, C. A., Vaux, D. L., Silke, J., & Day, C. L. (2008) · Cell Death & Differentiation

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 288

IAPs limit activation of RIP kinases by TNF receptor 1 during development

Moulin, M., Anderton, H., Voss, A. K., Thomas, T., Wong, W. W., Bankovacki, A., Feltham, R., Chau, D., Cook, W. D., Silke, J., et al. (2012) · The EMBO Journal

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 193

Replicates and repeats—what is the difference and is it significant?: A brief discussion of statistics and experimental design

Vaux, D. L., Fidler, F., & Cumming, G. (2012) · The EMBO Reports

Philosophy of Biology and Scientific ExplanationScientific Computing and Data Management

Cited by 155

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

Lazarou, M., Stojanovski, D., Frazier, A. E., Kotevski, A., Dewson, G., Craigen, W. J., Kluck, R. M., Vaux, D. L., & Ryan, M. T. (2010) · Journal of Biological Chemistry

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 111

Necroptosis induced by RIPK3 requires MLKL but not Drp1

Moujalled, D. M., Cook, W. D., Murphy, J. M., & Vaux, D. L. (2014) · Cell Death & Disease

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 103

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8

Gentle, I. E., Wong, W. W.-L., Evans, J. M., Bankovacki, A., Cook, W. D., Khan, N. R., Nachbur, U., Rickard, J., Anderton, H., Moulin, M., et al. (2011) · Journal of Biological Chemistry

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 96

Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Lalaoui, N., Merino, D., Giner, G., Vaillant, F., Chau, D., Liu, L., Kratina, T., Pal, B., Whittle, J. R., Etemadi, N., et al. (2020) · Cell Death & Differentiation

Cell death mechanisms and regulationHistone Deacetylase Inhibitors Research

Cited by 51