Norman, Thomas M.

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

Dixit, A., Parnas, O., Li, B., Chen, J., Fulco, C. P., Jerby-Arnon, L., Marjanovic, N. D., Dionne, D., Burks, T., Raychowdhury, R., et al. (2016) · Cell

Single-cell and spatial transcriptomicsCRISPR and Genetic Engineering

Cited by 1,863

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Adamson, B., Norman, T. M., Jost, M., Cho, M. Y., Nuñez, J. K., Chen, Y., Villalta, J. E., Gilbert, L. A., Horlbeck, M. A., Hein, M. Y., et al. (2016) · Cell

Endoplasmic Reticulum Stress and DiseaseSingle-cell and spatial transcriptomics

Cited by 1,193

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Replogle, J. M., Saunders, R. A., Pogson, A. N., Hussmann, J. A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E. J., Adelman, K., Lithwick-Yanai, G., et al. (2022) · Cell

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 795

Direct capture of CRISPR guides enables scalable, multiplexed, and multi-omic Perturb-seq

Replogle, J. M., Xu, A., Norman, T. M., Meer, E. J., Terry, J. M., Riordan, D., Srinivas, N., Mikkelsen, T. S., Weissman, J. S., & Adamson, B. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 465

Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

Replogle, J. M., Norman, T. M., Xu, A., Hussmann, J. A., Chen, J., Cogan, J. Z., Meer, E. J., Terry, J. M., Riordan, D. P., Srinivas, N., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 465

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., & Weissman, J. S. (2019) · Science

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 392

Molecular recording of mammalian embryogenesis

Chan, M. M., Smith, Z. D., Grosswendt, S., Kretzmer, H., Norman, T. M., Adamson, B., Jost, M., Quinn, J. J., Yang, D., Jones, M. G., et al. (2019) · Nature

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 364

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Jost, M., Santos, D. A., Saunders, R. A., Horlbeck, M. A., Hawkins, J. S., Scaria, S. M., Norman, T. M., Hussmann, J. A., Liem, C. R., Gross, C. A., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 164

Approaches to maximize sgRNA-barcode coupling in Perturb-seq screens

Adamson, B., Norman, T. M., Jost, M., & Weissman, J. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 34