Aifantis, Iannis

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 1,339

The bone marrow microenvironment at single-cell resolution

Tikhonova, A. N., Dolgalev, I., Hu, H., Sivaraj, K. K., Hoxha, E., Cuesta-Domínguez, Á., Pinho, S., Akhmetzyanova, I., Gao, J., Witkowski, M., et al. (2019) · Nature

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 936

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., et al. (2017) · Cell

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 707

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

Kim, E., Ilagan, J. O., Liang, Y., Daubner, G. M., Lee, S. C.-W., Ramakrishnan, A., Li, Y., Chung, Y. R., Micol, J.-B., Murphy, M. E., et al. (2015) · Cancer Cell

RNA Research and SplicingAcute Myeloid Leukemia Research

Cited by 575

Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

Wang, E., Lu, S. X., Pastore, A., Chen, X., Imig, J., Chun-Wei Lee, S., Hockemeyer, K., Ghebrechristos, Y. E., Yoshimi, A., Inoue, D., et al. (2019) · Cancer Cell

RNA Research and SplicingAcute Myeloid Leukemia Research

Cited by 338

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B.-S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., et al. (2015) · Immunity

Epigenetics and DNA MethylationT-cell and B-cell Immunology

Cited by 327

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., et al. (2015) · Cancer Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 236

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Di Micco, R., Fontanals-Cirera, B., Low, V., Ntziachristos, P., Yuen, S. K., Lovell, C. D., Dolgalev, I., Yonekubo, Y., Zhang, G., Rusinova, E., et al. (2014) · Cell Reports

Pluripotent Stem Cells ResearchGenomics and Chromatin Dynamics

Cited by 217

Vitamin C in stem cell reprogramming and cancer

Cimmino, L., Neel, B. G., & Aifantis, I. (2018) · Trends in Cell Biology

Vitamin C and Antioxidants ResearchPluripotent Stem Cells Research

Cited by 197

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

Sawai, C. M., Freund, J., Oh, P., Ndiaye-Lobry, D., Bretz, J. C., Strikoudis, A., Genesca, L., Trimarchi, T., Kelliher, M. A., Clark, M., et al. (2012) · Cancer Cell

Cancer-related Molecular PathwaysAcute Lymphoblastic Leukemia research

Cited by 183

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., et al. (2017) · Nature Communications

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 117

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells

Kallin, E. M., Rodríguez-Ubreva, J., Christensen, J., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E., & Graf, T. (2012) · Molecular Cell

Epigenetics and DNA MethylationAcute Myeloid Leukemia Research

Cited by 92

Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

Wang, E., Zhou, H., Nadorp, B., Cayanan, G., Chen, X., Yeaton, A. H., Nomikou, S., Witkowski, M. T., Narang, S., Kloetgen, A., et al. (2021) · Cell Stem Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 66

Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα

Akhmetzyanova, I., Aaron, T., Galbo, P., Tikhonova, A., Dolgalev, I., Tanaka, M., Aifantis, I., Zheng, D., Zang, X., & Fooksman, D. (2021) · Blood Advances

Multiple Myeloma Research and TreatmentsImmune cells in cancer

Cited by 39

Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia

Sirenko, M., Lee, S., Sun, Z., Chaligne, R., Loghavi, S., Asimomitis, G., Brierley, C. K., Bernard, E., Cai, S. F., Myers, R. M., et al. (2025) · Cell Stem Cell

Acute Myeloid Leukemia ResearchCancer Genomics and Diagnostics

Cited by 28