Diekman, Brian O.

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

Coryell, P. R., Diekman, B. O., & Loeser, R. F. (2021) · Nature Reviews Rheumatology

Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and Senescence

Cited by 761

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Novais, E. J., Tran, V. A., Johnston, S. N., Darris, K. R., Roupas, A. J., Sessions, G. A., Shapiro, I. M., Diekman, B. O., & Risbud, M. V. (2021) · Nature Communications

Spine and Intervertebral Disc PathologyTelomeres, Telomerase, and Senescence

Cited by 440

Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence

Liu, J.-Y., Souroullas, G. P., Diekman, B. O., Krishnamurthy, J., Hall, B. M., Sorrentino, J. A., Parker, J. S., Sessions, G. A., Gudkov, A. V., & Sharpless, N. E. (2019) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 306

Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

Diekman, B. O., Sessions, G. A., Collins, J. A., Knecht, A. K., Strum, S. L., Mitin, N. K., Carlson, C. S., Loeser, R. F., & Sharpless, N. E. (2018) · Aging Cell

Telomeres, Telomerase, and SenescenceOsteoarthritis Treatment and Mechanisms

Cited by 158

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types

Sauty, S. M., Shine, J., Bostan, H., Li, J.-L., Mieczkowski, P. A., Loeser, R. F., Diekman, B. O., & Gordenin, D. A. (2026) · PLOS Genetics

Osteoarthritis Treatment and MechanismsDNA Repair Mechanisms

Cited by 0

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types

Sauty, S. M., Shine, J., Bostan, H., Li, J.-L., Mieczkowski, P. A., Loeser, R. F., Diekman, B. O., & Gordenin, D. A. (2026) · PLoS Genetics

Osteoarthritis Treatment and MechanismsDNA Repair Mechanisms

Cited by 0