Lyssiotis, Costas A.

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming

Velez-Delgado, A., Donahue, K. L., Brown, K. L., Du, W., Irizarry-Negron, V., Menjivar, R. E., Lasse Opsahl, E. L., Steele, N. G., The, S., Lazarus, J., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 91

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

Little, A. C., Kovalenko, I., Goo, L. E., Hong, H. S., Kerk, S. A., Yates, J. A., Purohit, V., Lombard, D. B., Merajver, S. D., & Lyssiotis, C. A. (2020) · Communications Biology

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 88

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Halbrook, C. J., Thurston, G., Boyer, S., Anaraki, C., Jiménez, J. A., McCarthy, A., Steele, N. G., Kerk, S. A., Hong, H. S., Lin, L., et al. (2022) · Nature Cancer

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 80

Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway

Boyer, S., Lee, H.-J., Steele, N., Zhang, L., Sajjakulnukit, P., Andren, A., Ward, M. H., Singh, R., Basrur, V., Zhang, Y., et al. (2022) · eLife

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 56

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

Xu, J., Reznik, E., Lee, H.-J., Gundem, G., Jonsson, P., Sarungbam, J., Bialik, A., Sanchez-Vega, F., Creighton, C. J., Hoekstra, J., et al. (2019) · eLife

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 43

NetrinG1(+) cancer-associated fibroblasts generate unique extracellular vesicles that support the survival of pancreatic cancer cells under nutritional stress

Raghavan, K. S., Francescone, R., Franco-Barraza, J., Gardiner, J. C., Vendramini-Costa, D. B., Luong, T., Pourmandi, N., Andren, A., Kurimchak, A., Ogier, C., et al. (2022) · Cancer Research Communications

Extracellular vesicles in diseasePancreatic and Hepatic Oncology Research

Cited by 40

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

Anglin, J., Zavareh, R. B., Sander, P. N., Haldar, D., Mullarky, E., Cantley, L. C., Kimmelman, A. C., Lyssiotis, C. A., & Lairson, L. L. (2018) · Bioorganic & Medicinal Chemistry Letters

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 39

Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 10

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

Krall, A. S., Mullen, P. J., Surjono, F., Momcilovic, M., Schmid, E. W., Halbrook, C. J., Thambundit, A., Mittelman, S. D., Lyssiotis, C. A., Shackelford, D. B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 5