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The KRAS-Mutant Consensus Molecular Subtype 3 Reveals an Immunosuppressive Tumor Microenvironment in Colorectal Cancer

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KRAS-Driven Tumorigenesis and KRAS-Driven Therapy in Pancreatic Adenocarcinoma

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GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration

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Fibroblast STAT3 Activation Drives Organ-Specific Premetastatic Niche Formation

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Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases

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Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma

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Top advances of the year: Pancreatic cancer

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With a little help from my T friends: T cells increase efficacy of KRAS (G12D) inhibitors

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Stromal Cells in Early Inflammation-Related Pancreatic Carcinogenesis—Biology and Its Potential Role in Therapeutic Targeting

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Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer

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Advancement of single-cell sequencing for clinical diagnosis and treatment of pancreatic cancer

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Olaparib and Radiotherapy Induce Type I Interferon– and CD8+ T Cell–Dependent Sensitization to Immunotherapy in Pancreatic Cancer

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CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC

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High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer

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Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression

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Age-Related Decline in Pancreas Regeneration Is Associated With an Increased Proinflammatory Response to Injury

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Reorganization of pancreas circadian transcriptome with aging

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KRASG12D inhibition in pancreatic cancer: Fas expression facilitates immune clearance

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Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population

Sini, M. C., Doro, M. G., Frogheri, L., Zinellu, A., Paliogiannis, P., Porcu, A., Scognamillo, F., Delogu, D., Santeufemia, D. A., Persico, I., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04923-3 · Cited by 4 · see citing works

CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRAS G12D inhibition in pancreatic ductal adenocarcinomaPreprint

McAndrews, K. M., Mahadevan, K. K., Li, B., Sockwell, A. M., Morse, S. J., Kelly, P. J., Patel, S. I., Kirtley, M. L., Diaz, B. A. M., Lyu, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.29.635543 · Cited by 4 · see citing works

Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer

Elhossiny, A. M., Kadiyala, P., Okoye, J. O., Hiraki, H. L., Procario, M. C., Giridharan, T., Watkoske, H. R., Ruckert, M. T., Wang, J., Griffith, B. D., et al. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-2001 · Cited by 3 · see citing works

Case report: A successful case of targeted immunotherapy for locally advanced pancreatic cancer under non-surgical conditions

Bi, Y., Yv, H., Ma, X., & Chen, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1519186 · Cited by 3 · see citing works

Activin A signaling stimulates neutrophil activation and macrophage migration in pancreatitis

Wiley, M. B., Bauer, J. I., Álvarez, V., Mehrotra, K., Cheng, W., Kolics, Z., Giarrizzo, M., Ingle, K., Bialkowska, A. B., & Jung, B. H. (2024) · Scientific Reports · doi:10.1038/s41598-024-60065-y · Cited by 3 · see citing works

Oncogenic KRAS promotes pancreatic ductal adenocarcinoma (PDAC) through post-transcriptionally regulated KRAS-induced granules (KGs)Preprint

Bortoletto, A. S., Yang, Z., Cardenas, M. G., Wang, M.-T., McCormick, F. P., & Parchem, R. J. (2023) · Research Square · doi:10.21203/rs.3.rs-3064215/v1 · Cited by 3 · see citing works

Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage ReprogrammingPreprint

Thielman, N. R. J., Funes, V., Davuluri, S., Ibanez, H. E., Sun, W., Fu, J. L., Li, K., Muth, S. T., Pan, X., Fujiwara, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563862 · Cited by 3 · see citing works

Wilms Tumor 1–Expressing Stromal Cells Promote Pancreatic Cancer Progression

Bischoff, A. C., Brown, K. L., Lasse-Opsahl, E., Watkoske, H. R., Espinoza, C. E., Okoye, J., Olivei, A., Green, L. M., Rai, R., The, S., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-25-1014

Regulatory Effects of Oncogenes and Tumor Suppressor Genes on Tumor Immune Microenvironment

Shu-Yi, T. A. N., & Zhang, J. (2025) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/j.pibb.2025.0317 · Cited by 2 · see citing works

One Mutation to Rule Them All: Mutant KRAS Controls Tumor Intrinsic and Microenvironment Signaling

Müller, S., & Krishnamurty, A. T. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-3682 · Cited by 2 · see citing works

SMURF2 Facilitates GAP17 Isoform 1 Membrane Displacement to Promote Mutant p53–KRAS Oncogenic Synergy

Ray, P., Shukla, S., Zhang, Y., Donahue, K. L., Nancarrow, D. J., Kasturirangan, S., Shankar, S., Cuneo, K. C., Thomas, D. G., Gadgeel, S. M., et al. (2025) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-24-0701 · Cited by 2 · see citing works

Exposomal determinants of non-genetic plasticity in tumor initiation

Carra, D., Maas, S. C. E., Seoane, J. A., & Alonso‐Curbelo, D. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.01.010 · Cited by 2 · see citing works

Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis

Sozzi, S., Manni, I., Ercolani, C., Diodoro, M. G., Bartolazzi, A., Spallotta, F., Piaggio, G., Monteonofrio, L., Soddu, S., Rinaldo, C., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03189-3 · Cited by 1 · see citing works

Personalized Neoadjuvant Chemotherapy for Gastrointestinal Cancers: Shaping Imprecision to be Precise

Høgdall, D., Schou, J. V., Bromann, J. J. A., Andersen, J. B., & O’Rourke, C. J. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-4309 · Cited by 1 · see citing works

Precancerous microenvironment: A signalling perspective

Qin, X. (2026) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102611 · Cited by 1 · see citing works

Breaking barriers: nano-boosted drug delivery systems in overcoming the defenses of pancreatic cancer

Wang, Y., Zhang, Y., Wang, X., Zhao, W., Li, Q., Zhou, M., Liu, Y., Yi, X., He, J. I., Li, Y. P., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02712-8 · Cited by 1 · see citing works

Finding Method in the Madness of Pancreatic Carcinogenesis

Sherman, M. H. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.03.004

Re‐interpreting tumour behaviour and the tumour microenvironment as normal responses to tissue disorganisation

Edwards, P. A. (2023) · The Journal of Pathology · doi:10.1002/path.6070

Calligraphy tool offers clues to the origin of pancreatic cancer

Bednar, F., & di Magliano, M. P. (2023) · Nature · doi:10.1038/d41586-023-02518-4

WITHDRAWN: Oncogenic KRAS G12D extrinsically induces an immunosuppressive microenvironment in lung adenocarcinomaPreprint

Opsahl, E. L. L., Baliira, R. K., Barravecchia, I., McLintock, E., Lee, J. M., Ferris, S. F., Espinoza, C. E., Hinshaw, R., Cavanaugh, S., Robotti, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.16.568090

Mechanistic Insights Driving Translational Progress in Pancreatic Cancer

Strickland, L. N., Klute, K. A., & Bailey, J. M. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101685

Additional file 1 of Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population

Sini, M. C., Doro, M. G., Frogheri, L., Zinellu, A., Paliogiannis, P., Porcu, A., Scognamillo, F., Delogu, D., Santeufemia, D. A., Persico, I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673525

Additional file 2 of Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population

Sini, M. C., Doro, M. G., Frogheri, L., Zinellu, A., Paliogiannis, P., Porcu, A., Scognamillo, F., Delogu, D., Santeufemia, D. A., Persico, I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26673528

Additional file 1 of Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis

Sozzi, S., Manni, I., Ercolani, C., Diodoro, M. G., Bartolazzi, A., Spallotta, F., Piaggio, G., Monteonofrio, L., Soddu, S., Rinaldo, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.27129495

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition

Reyes, J. (2026) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · doi:10.5281/zenodo.18892592

Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer

Zhang, Y., Kadiyala, P., Yan, W., Brown, K. L., Avritt, F. R., Donahue, K. L., Procario, M. C., Okoye, J. O., Giridharan, T., Elhossiny, A. M., et al. (2026) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-1300

CAF-derived PAI-1 serves as an EGFR ligand and fuels KRAS-mutant pancreatic cancer

Wang, Y., Liu, C., Gao, S., Wang, B., Wang, H., Shi, Z., Xia, S., Li, J., Yao, X., Guo, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75132-3

Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway

Du, H.-J., Fang, W., Zhang, Q.-C., Chen, N.-N., Zhang, F., Zhao, J.-G., Lv, J.-H., Anthony, K. M., Chen, H., Zou, J., et al. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-026-01880-z

Mechanisms of Immune Cell Dysregulation in Pancreatic Ductal Adenocarcinoma

Ahmady, F., Luwor, R. B., & Kannourakis, G. (2026) · Biology · doi:10.3390/biology15181599 · Cited by 1 · see citing works

Pulsed Field Ablation Enables Stromal Manipulation and Tumor Reduction in Pancreatic Ductal AdenocarcinomaPreprint

Demmel, M. V., Strickland, L. N., McAndrews, K. L., Turabi, K. S., Waller, A., Dash, S., Sardarni, U. K., Thosani, N. C., Viswanathan, R., & Bailey, J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.06.756887

Abstract IA19: Oncogenic KRAS and the regulation of the pancreatic cancer microenvironment.

di Magliano, M. P. (2023) · Molecular Cancer Research · doi:10.1158/1557-3125.ras23-ia19

Abstract PR-016: Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming

Velez-Delgado, A., Donahue, K. L., Brown, K. L., Du, W., Irizarry-Negron, V. M., Menjivar, R. E., Opsahl, E. L. L., Steele, N. G., The, S., Lazarus, J., et al. (2021) · Cancer Research · doi:10.1158/1538-7445.panca21-pr-016 · Cited by 1 · see citing works

Abstract A68: Oncogenic Kras prevents myeloid cell-mediated pancreatic tissue repair

Zhang, Y., Yan, W., Mathew, E., Kane, K. T., & di Magliano, M. P. (2016) · Cancer Research · doi:10.1158/1538-7445.panca16-a68

Abstract IA12: Oncogenic KRAS and the inflammatory microenvironment in pancreatic cancer

Zhang, Y., Yan, W., Bednar, F., Wan, S., Collins, M. A., Evans, R. A., Mathew, E., Welling, T. H., Vonderheide, R. H., & di Magliano, M. P. (2014) · Molecular Cancer Research · doi:10.1158/1557-3125.rasonc14-ia12 · Cited by 1 · see citing works

Abstract C084: Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer

Caligiuri, G., Thalappillil, J. S., Shakiba, M., Nadella, S., Hinds, J., Courtois, E. T., Flynn, W. F., Alagesan, B., Yordanov, G. N., Kaminow, B., et al. (2022) · Cancer Research · doi:10.1158/1538-7445.panca22-c084