Yancopoulos, George D.

The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies

Copin, R., Baum, A., Wloga, E., Pascal, K. E., Giordano, S., Fulton, B. O., Zhou, A., Negron, N., Lanza, K., Chan, N., et al. (2021) · Cell

SARS-CoV-2 and COVID-19 ResearchMonoclonal and Polyclonal Antibodies Research

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ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

Gusarova, V., Alexa, C. A., Wang, Y., Rafique, A., Kim, J. H., Buckler, D., Mintah, I. J., Shihanian, L. M., Cohen, J. C., Hobbs, H. H., et al. (2015) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 210

Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., et al. (2020) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 208

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion

Gusarova, V., Alexa, C. A., Na, E., Stevis, P. E., Xin, Y., Bonner-Weir, S., Cohen, J. C., Hobbs, H. H., Murphy, A. J., Yancopoulos, G. D., et al. (2014) · Cell

Pancreatic function and diabetesLipid metabolism and disorders

Cited by 202

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response

Xin, Y., Dominguez Gutierrez, G., Okamoto, H., Kim, J., Lee, A.-H., Adler, C., Ni, M., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Diabetes

Pancreatic function and diabetesEndoplasmic Reticulum Stress and Disease

Cited by 191

Activin A more prominently regulates muscle mass in primates than does GDF8

Latres, E., Mastaitis, J., Fury, W., Miloscio, L., Trejos, J., Pangilinan, J., Okamoto, H., Cavino, K., Na, E., Papatheodorou, A., et al. (2017) · Nature Communications

Muscle Physiology and DisordersTGF-β signaling in diseases

Cited by 185

Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8 + T cell dysfunction and maintain memory phenotype

Wang, B., Zhang, W., Jankovic, V., Golubov, J., Poon, P., Oswald, E. M., Gurer, C., Wei, J., Ramos, I., Wu, Q., et al. (2018) · Science Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 167

IL-22 promotes fibroblast-mediated wound repair in the skin

McGee, H. M., Schmidt, B. A., Booth, C. J., Yancopoulos, G. D., Valenzuela, D. M., Murphy, A. J., Stevens, S., Flavell, R. A., & Horsley, V. (2013) · Journal of Investigative Dermatology

Wound Healing and TreatmentsCytokine Signaling Pathways and Interactions

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Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Latres, E., Pangilinan, J., Miloscio, L., Bauerlein, R., Na, E., Potocky, T. B., Huang, Y., Eckersdorff, M., Rafique, A., Mastaitis, J., et al. (2015) · Skeletal Muscle

Muscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

Cited by 143

Agouti-related protein-deficient mice display an age-related lean phenotype

Wortley, K. E., Anderson, K. D., Yasenchak, J., Murphy, A., Valenzuela, D., Diano, S., Yancopoulos, G. D., Wiegand, S. J., & Sleeman, M. W. (2005) · Cell Metabolism

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 128

Germline Mutations in CIDEB and Protection against Liver Disease

Verweij, N., Haas, M. E., Nielsen, J. B., Sosina, O. A., Kim, M., Akbari, P., De, T., Hindy, G., Bovijn, J., Persaud, T., et al. (2022) · New England Journal of Medicine

Liver Disease Diagnosis and TreatmentGenetic Associations and Epidemiology

Cited by 127

Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank

Van Hout, C. V., Tachmazidou, I., Backman, J. D., Hoffman, J. X., Ye, B., Pandey, A. K., Gonzaga-Jauregui, C., Khalid, S., Liu, D., Banerjee, N., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 110

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

Okamoto, H., Kim, J., Aglione, J., Lee, J., Cavino, K., Na, E., Rafique, A., Kim, J. H., Harp, J., Valenzuela, D. M., et al. (2015) · Endocrinology

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 100

Antidrug Antibodies in Patients Treated with Alirocumab

Roth, E. M., Goldberg, A. C., Catapano, A. L., Torri, A., Yancopoulos, G. D., Stahl, N., Brunet, A., Lecorps, G., & Colhoun, H. M. (2017) · New England Journal of Medicine

Lipoproteins and Cardiovascular HealthBiosimilars and Bioanalytical Methods

Cited by 90

Glucagon contributes to liver zonation

Cheng, X., Kim, S. Y., Okamoto, H., Xin, Y., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

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Peripheral Myelin Protein 22 Is in Complex with α6β4 Integrin, and Its Absence Alters the Schwann Cell Basal Lamina

Amici, S. A., Dunn, W. A., Murphy, A. J., Adams, N. C., Gale, N. W., Valenzuela, D. M., Yancopoulos, G. D., & Notterpek, L. (2006) · The Journal of Neuroscience

Hereditary Neurological DisordersPeripheral Neuropathies and Disorders

Cited by 75

Structural insights into the assembly of gp130 family cytokine signaling complexes

Zhou, Y., Stevis, P. E., Cao, J., Saotome, K., Wu, J., Glatman Zaretsky, A., Haxhinasto, S., Yancopoulos, G. D., Murphy, A. J., Sleeman, M. W., et al. (2023) · Science Advances

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

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GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates

Mastaitis, J. W., Gomez, D., Raya, J. G., Li, D., Min, S., Stec, M., Kleiner, S., McWilliams, T., Altarejos, J. Y., Murphy, A. J., et al. (2025) · Nature Communications

Muscle Physiology and DisordersNutrition and Health in Aging

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Activin E–ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice

Adam, R. C., Pryce, D. S., Lee, J. S., Zhao, Y., Mintah, I. J., Min, S., Halasz, G., Mastaitis, J., Atwal, G. S., Aykul, S., et al. (2023) · Proceedings of the National Academy of Sciences

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 44

GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial

Gonzalez Trotter, D., Donahue, S., Wynne, C., Ali, S., Parasoglou, P., Boyapati, A., Mohammadi, K., Musser, B. J., Meier, P., Mastaitis, J., et al. (2025) · Nature Communications

Muscle Physiology and DisordersTGF-β signaling in diseases

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