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Blocking GP130 binding in interleukin-11 through site-specific PEGylation attenuates bleomycin-induced pulmonary fibrosis in mice

Wang, S., Wang, P., Zhang, M., Song, X., Wei, L., Ma, X., Yao, X., Zhang, S., Chen, Z., Zheng, Y., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124916 · Cited by 6

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist SignalingPreprint

Expòsit, M., Abedi, M. H., Krishnakumar, A., Jain, S., Yu, T.-Y., Hercus, T. R., Mathew, D., Gray-Gaillard, S. L., Chen, Z., Grubbe, W. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.12.681819 · Cited by 6

Pharmacological modulation of gp130 signalling enhances Achilles tendon repair by regulating tenocyte migration and collagen synthesis via SHP2-mediated crosstalk of the ERK/AKT pathway

He, Y., Zhou, H., Qu, Y., Chi, R., Xu, H., Chen, S., Meng, C., Liu, Q., Huang, X., You, H., et al. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116370 · Cited by 5

Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies

Pudewell, S., Heuser, J., Dorogobed, I., Lipinski, B., Tran, T. H. H., Metzenmacher, P., Kunze, R., Geyer, F. K., Zielonka, S., Floss, D. M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1613004 · Cited by 5

Towards a structural and functional analysis of the immunoglobulin-fold proteome

Tawfeeq, C., Song, J., Khaniya, U., Madej, T., Wang, J., Youkharibache, P., & Abrol, R. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.11.002 · Cited by 5

The CLCF1-CNTFR axis drives an immunosuppressive tumor microenvironment and blockade enhances the effects of established cancer therapiesPreprint

Sweet-Cordero, A., Marini, K. D., Champion, E. C., Lee, A. G., Young, I., Leung, S. G., Mathey‐Andrews, N., Jacks, T., Jackson, P. K., & Cochran, J. R. (2024) · Research Square · doi:10.21203/rs.3.rs-4046823/v1 · Cited by 5

Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex

Gao, B., Liu, H., Zhu, M., Zhang, S., Wang, M., Ruan, Y., & Zheng, Y. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.01.014 · Cited by 4

Hexosamine biosynthesis dysfunction-induced LIFR N-glycosylation deficiency exacerbates steatotic liver ischemia/reperfusion injury

Liu, R., Wang, G., Qian, Y., Jiang, Z., Wang, W., Cai, M., Zhang, S., Wang, G., Wang, C., Zou, T., et al. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156258 · Cited by 4

Understanding complex formation of gp130 cytokines for the design of selective therapeutics

Roth, I. R., Fuehring, J. I., & Garbers, C. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120105 · Cited by 3

Updated Mechanisms of IL ‐6 in Human Endothelial Cells

Pirlet, E., Alders, L., Lins, P. M. P., & Bronckaers, A. (2025) · The FASEB Journal · doi:10.1096/fj.202500492rr · Cited by 3

Structural plasticity of human leptin binding to its receptor LepR

Xie, Y., Li, X., Qi, J., Shang, G., Lu, D., & Gao, G. F. (2023) · hLife · doi:10.1016/j.hlife.2023.10.010 · Cited by 3

Investigating plasticity within the interleukin-6 family with AlphaFold-Multimer

Düsterhöft, S., Greve, J. N., & Garbers, C. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.02.030 · Cited by 3

High-yield production of recombinant CLCF1 protein fused with human serum albumin in animal cells and toxicity evaluation in rodents

Lee, J., Kang, J. S., Yang, Y. R., & Park, J. H. (2025) · Protein Expression and Purification · doi:10.1016/j.pep.2025.106740 · Cited by 2

CLCF1 promotes IL12Rβ2 proteolysis and limits Th1 differentiation

Laplante, V., Rousseau, M., Pasquin, S., Bourel, C., Uriarte, M., Affar, E. B., Najmanovich, R., Lesage, S., & Gauchat, J. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156989 · Cited by 2

CRLF1 Secreted by Cardiac Fibroblasts Promotes Human Hypertrophic Cardiomyopathy

Lin, B., Wang, J., Li, C., Wang, S., Shen, M., Hu, L., Chen, L., Zhou, F., Liu, Y., Yang, J. P., et al. (2026) · Circulation · doi:10.1161/circulationaha.125.075290 · Cited by 2

Structural Model of the Oncostatin M (OSM)-OSMRβ-gp130 Ternary Complex Reveals Pathways of Allosteric Communication in OSM Signaling

Du, Q., Luo, D., Xue, W., & Qian, Y. (2025) · Current Medicinal Chemistry · doi:10.2174/0109298673362742250508113436 · Cited by 1

Structural insights into IL-31 signaling inhibition by a neutralizing antibody

Guo, T., Zheng, Y., Fan, Z., Liu, P., Chai, Y., Liao, X., Zhang, C., Pang, X., Li, D., Gao, F., et al. (2025) · Structure · doi:10.1016/j.str.2025.09.002 · Cited by 1

Insights into the regulation and signaling landscape of cardiotrophin-like cytokine factor 1 (CLCF1)

Rousseau, M., Côté, F., Chemtob, S., Gauchat, J., Pasquin, S., & Lesage, S. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120123 · Cited by 1

Transfer learning algorithm assisted in the discovery of novel gp130 inhibitors and their application in colorectal cancer treatment

Guan, J., Xiao, L., Hong, J., (29560), J. W., Cai, G., Richardson, D. R., Liao, Y., & Yu, W. (2026) · Targetome · doi:10.48130/targetome-0026-0010 · Cited by 1

Cytokine multimerization: when more is more and sometimes less

Rudloff, I., Christie, M., Deen, N. S., Ellisdon, A. M., Nold‐Petry, C. A., & Nold, M. F. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01290-6 · Cited by 1

Realizing the potential of agonistic antibody immunotherapy

Cragg, M. S., Yu, X., Paluch, C., & Davis, S. J. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01442-2 · Cited by 1

Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction

Dehkhoda, F., Chhabra, Y., Whelan, F., Nowell, C. J., Morris, M. J., Furness, S. G. B., & Brooks, A. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag118 · Cited by 1

Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomasPreprint

Zhou, Y., Cao, J., Ramlall, T. F., McGoldrick, L. L., Jones, J. L., Cook, A. S., Leidich, R., Sleeman, M. W., Olson, W. C., Stevis, P. E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.11.685192

Caractérisation des rôles de CLCF1 dans la biologie de l’IL-12

Laplante, V. (2025) · doi:10.71781/32656

The secretory protein, CLCF1, improves cholestatic liver disease by inhibiting hepatic bile acid synthesis and promoting bile acid excretion

Liu, M., Su, Y., Hu, Y., Shen, M., Bao, S., Gong, Y., Ji, Y., Wang, L., Zhang, Y., Wang, X., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09847-w

Metal-induced energy transfer uncovers activation-induced axial reorganization of signaling complexes inside cellsPreprint

Wienbeuker, E., Felker, A., Nevskyi, O., Harms, S. T., Marx, D., Tanzusch, K., Chizhik, A. M., Kurre, R., You, C., Enderlein, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.23.719849

From in silico to in vitro: discovery and validation of peptide modulators of IL-6/IL-6R signaling in rheumatoid arthritis

Yang, J., Wang, Y., Huang, J., Zhang, J., & Xie, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1794095

The Role of Leukemia Inhibitory Factor in Attenuating Skeletal Muscle Atrophy: Mechanisms to Exercise Interventions

Jiang, N., Wang, S., Zhang, J., & Jia, D. (2026) · Cells · doi:10.3390/cells15110981

Herpes simplex virus type 1 interferes with signal transducer and activator of transcription 3 expression in infected mature dendritic cells

Birzer, A., Draßner, C., Muehl-Zuerbes, P., Kuhnt, C., Krawczyk, A., Thoma‐Kress, A. K., Steinkasserer, A., & Popella, L. (2026) · Journal of General Virology · doi:10.1099/jgv.0.002280

Cryo-EM structure of the interleukin-31 receptor complex defines non-canonical interactions that confer receptor specificity

Feng, Y., Qian, G., Wei, Z., & Dong, X. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113472

Multi-omics analysis of therapeutic targets of Terrestris saponin D in pulmonary fibrosis

Li, S., Zhang, H., Wu, G., 柏玉坤, Zhao, D., Yang, X., Yang, D., Guo, J., Lu, Y., & An, M. (2026) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2026.117754

Surrogate Ligand-Encoded Leptin Receptor Dimer Geometry Modulates Type I Tall Cytokine Receptor SignalingPreprint

Yan, L., Chen, X., Tao, P., Wang, F., Wang, F., Shen, J., Shen, Y., Zhang, L., Huang, Q., Dong, L., et al. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7564260

LIF and let die: Generation, mechanistical, and structural characterization of bispecific antibodies triggering leukemia inhibitory factor (LIF) receptor activation independent of the cytokine LIF

Harwardt, J., Pudewell, S., Keil, K., Lipinski, B., Unmuth, L., Tran, T. H. H., Guarnera, E., Elter, D., Pekar, L., Floss, D. M., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113634

Selective inhibition of IL-6 trans-signalling reveals distinct mechanisms of human classic and trans-signalling receptor-complex formation

Rieneck, E., Haak, J. R., Asgarov, K., Pallandre, J., Wundrack, N., Ettich, J., Miri, N., Floss, D. M., Scheller, J., Garbers, C., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-11014-0

IL-37a, an Anti-Inflammatory Molecule and a Nuclear Cytokine: Linking Alternative Splicing, Nuclear Trafficking, and Epigenetic Regulation of Inflammation

Wang, Z.-Y., Feng, Y.-Q., Hu, X.-X., Zhang, Y., Zhang, X.-Y., Wang, S., & Xie, J. (2026) · Journal of Interferon & Cytokine Research · doi:10.1177/10799907261499951

Following the Assembly of Receptor Complex

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A structural template for gp130-cytokine signaling assemblies

Chow, D., Brevnova, L., He, X. L., Martick, M. M., Bankovich, A. J., & García, K. C. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00317-8 · Cited by 33

Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane

Schroers, A., Hecht, O., Kallen, K., Pachta, M., Rose‐John, S., & Grötzinger, J. (2005) · Protein Science · doi:10.1110/ps.041117105 · Cited by 78

A New Paradigm of Cytokine Action Revealed by Viral IL-6 Complexed to gp130: Implications for GCSF Interaction with GCSFR

Chow, D., Brevnova, L., He, X. L., & García, K. C. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50405-8

The Cytokine Receptor gp130: Faithfully Promiscuous

Müller‐Newen, G. (2003) · Science Signaling · doi:10.1126/scisignal.2012003pe40 · Cited by 7