Mallette, Frédérick A.

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 406

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science

Neutrophil, Myeloperoxidase and Oxidative MechanismsRetinal Diseases and Treatments

Cited by 283

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

Oubaha, M., Miloudi, K., Dejda, A., Guber, V., Mawambo, G., Germain, M.-A., Bourdel, G., Popovic, N., Rezende, F. A., Kaufman, R. J., et al. (2016) · Science Translational Medicine

Telomeres, Telomerase, and SenescenceRetinal Diseases and Treatments

Cited by 259

DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A., & Ferbeyre, G. (2006) · Molecular Biology of the Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 252

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Deschênes-Simard, X., Gaumont-Leclerc, M.-F., Bourdeau, V., Lessard, F., Moiseeva, O., Forest, V., Igelmann, S., Mallette, F. A., Saba-El-Leil, M. K., Meloche, S., et al. (2013) · Genes & Development

Telomeres, Telomerase, and SenescenceMelanoma and MAPK Pathways

Cited by 194

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

Sapieha, P., & Mallette, F. A. (2018) · Trends in Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 193

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Carbonneau, M., M. Gagné, L., Lalonde, M.-E., Germain, M.-A., Motorina, A., Guiot, M.-C., Secco, B., Vincent, E. E., Tumber, A., Hulea, L., et al. (2016) · Nature Communications

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 180

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell

Melanoma and MAPK PathwaysEpigenetics and DNA Methylation

Cited by 156

The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Mallette, F. A., & Ferbeyre, G. (2007) · Cell Cycle

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 125

Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., Huot, G., & Ferbeyre, G. (2007) · Journal of Biological Chemistry

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 51

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., et al. (2018) · Cancer Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 46

A genome-wide screen reveals that Dyrk1A kinase promotes nucleotide excision repair by preventing aberrant overexpression of cyclin D1 and p21

Bélanger, F., Roussel, C., Sawchyn, C., St-Hilaire, E., Gezzar-Dandashi, S., Kimenyi Ishimwe, A. B., Mallette, F. A., Wurtele, H., & Drobetsky, E. (2023) · Journal of Biological Chemistry

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 9