Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
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Genetic interference with senescence-essential factors, especially using inducible systems, underscored that, similar to other biological states, senescence is not necessarily irreversible.
“Of note, genetic interference with senescence- essential factors, especially using inducible systems, underscored that, similar to other biological states, senescence is not necessarily irreversible 125,126,149 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [149]
Robust evidence from studies in primary cell cultures supports the view that fully senescent cells might indeed re-acquire proliferative capacity while remaining, to some extent, locked into other features of cellular senescence.
“Nevertheless, robust evidence from studies in primary cell cultures supports the view that fully senescent cells might indeed re- acquire proliferative capacity while remaining, to some extent, locked into other features of cellular senescence 5,149 .”
From Senescence and cancer — role and therapeutic opportunities (2022) · cites this paper as [149]
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Senescence and cancer — role and therapeutic opportunities
Schmitt, C. A., Wang, B., & Demaria, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00668-4 · Cited by 794 · see citing works
Self-citationChemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity
Guillon, J., Petit, C., Toutain, B., Guette, C., Lelièvre, E., & Coqueret, O. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1652047 · Cited by 102 · see citing works
- Authors
- Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., Silvis, M. R., Qutob, N., van Rooijen, E., Werner-Klein, M., Li, L., Dhawan, D., Meierjohann, S., Reimann, M., Elkahloun, A., Treitschke, S., Dörken, B., Speck, C., Mallette, F. A., Zon, L. I., Holmen, S. L., Peeper, D. S., Samuels, Y., Schmitt, C. A., & Lee, S.
- Corresponding author
- Schmitt, Clemens A.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 33
- Issue
- 4
- Pages
- 785
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2888416224
- Cited by
- 46
- References
- 0
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 1
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/M003760/1)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- LSD1, JMJD2C, melanoma, cellular senescence, oncogenic Ras, BRAF, E2F target genes, histone demethylation, tumor growth inhibition, epigenetic therapy
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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