Sudarshan, Sunil

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

Sullivan, L. B., Martinez-Garcia, E., Nguyen, H., Mullen, A. R., Dufour, E., Sudarshan, S., Licht, J. D., Deberardinis, R. J., & Chandel, N. S. (2013) · Molecular Cell

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 304

l -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

Shim, E.-H., Livi, C. B., Rakheja, D., Tan, J., Benson, D., Parekh, V., Kho, E.-Y., Ghosh, A. P., Kirkman, R., Velu, S., et al. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 280

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

Sudarshan, S., Sourbier, C., Kong, H.-S., Block, K., Romero, V. A. V., Yang, Y., Galindo, C., Mollapour, M., Scroggins, B., Goode, N., et al. (2009) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 217

The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer

Nam, H., Kundu, A., Karki, S., Brinkley, G. J., Chandrashekar, D. S., Kirkman, R. L., Liu, J., Liberti, M. V., Locasale, J. W., Mitchell, T., et al. (2021) · JCI Insight

Cancer, Hypoxia, and MetabolismTGF-β signaling in diseases

Cited by 36