l -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Mutation in <i>TET2</i> in Myeloid Cancers

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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Integrated molecular analysis of clear-cell renal cell carcinoma

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

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2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

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Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

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( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

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Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint

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Papillary Thyroid Carcinoma

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

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RUNX1Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group

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5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis

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Patterns of Gene Expression and Copy-Number Alterations in von-Hippel Lindau Disease-Associated and Sporadic Clear Cell Carcinoma of the Kidney

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Germline SDHB Mutations and Familial Renal Cell Carcinoma

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In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

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5-hydroxymethylcytosine and its potential roles in development and cancer

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A gene encoding a putative FAD-dependent <scp>l</scp> -2-hydroxyglutarate dehydrogenase is mutated in <scp>l</scp> -2-hydroxyglutaric aciduria

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<i>TET2</i> Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group

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Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

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l ‐2‐Hydroxyglutaric aciduria, a defect of metabolite repair

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Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

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L-2-hydroxyglutaric aciduria and brain malignant tumors: A predisposing condition?

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Expression Profile of the Polycomb Group Protein Enhancer of Zeste Homologue 2 and its Prognostic Relevance in Renal Cell Carcinoma

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Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate

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Novel insights into L ‐2‐hydroxyglutaric aciduria: Mass isotopomer studies reveal 2‐oxoglutaric acid as the metabolic precursor of L ‐2‐hydroxyglutaric acid

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Wilms Tumor in a Child with L-2-hydroxyglutaric Aciduria

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Fundamentals of Cancer Metabolism

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Hypoxia Induces Production of L-2-Hydroxyglutarate

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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

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L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

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Metabolic adaptation in hypoxia and cancer

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Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

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Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

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Abstract LB-131: Elevated (L) -2-hydroxyglutarate promotes loss of 5-hydroxymethylcytosine in clear cell renal cancer

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Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer

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Oncometabolite L-2-Hydroxyglutarate Promotes Oncogenesis of Renal Cell Carcinomas by Down-Regulating Differentiation

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Abstract 5482: L-2HG/ L2HGDH axis as therapeutic target for kidney cancer

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