Craik, Charles S.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

Global landscape of HIV–human protein complexes

Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., et al. (2012) · Nature

HIV Research and TreatmentAdvanced Proteomics Techniques and Applications

Cited by 731

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

Jäger, S., Kim, D. Y., Hultquist, J. F., Shindo, K., LaRue, R. S., Kwon, E., Li, M., Anderson, B. D., Yen, L., Stanley, D., et al. (2012) · Nature

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 352

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Dang, S., Feng, S., Tien, J., Peters, C. J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbühler, K., Ye, W., Qi, L., et al. (2017) · Nature

Ion channel regulation and functionIon Transport and Channel Regulation

Cited by 333

A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms

Williamson, A. L., Lecchi, P., Turk, B. E., Choe, Y., Hotez, P. J., McKerrow, J. H., Cantley, L. C., Sajid, M., Craik, C. S., & Loukas, A. (2004) · Journal of Biological Chemistry

Parasites and Host InteractionsHelminth infection and control

Cited by 181

A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy

Zhang, Z., Rohweder, P. J., Ongpipattanakul, C., Basu, K., Bohn, M.-F., Dugan, E. J., Steri, V., Hann, B., Shokat, K. M., & Craik, C. S. (2022) · Cancer Cell

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 136

Cullin E3 Ligases and Their Rewiring by Viral Factors

Mahon, C., Krogan, N., Craik, C., & Pick, E. (2014) · Biomolecules

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 101

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Schirle Oakdale, N. T., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 87

GPS-Prot: A web-based visualization platform for integrating host-pathogen interaction data

Fahey, M. E., Bennett, M. J., Mahon, C., Jäger, S., Pache, L., Kumar, D., Shapiro, A., Rao, K., Chanda, S. K., Craik, C. S., et al. (2011) · BMC Bioinformatics

Bioinformatics and Genomic NetworksHIV Research and Treatment

Cited by 87

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Miller-Vedam, L. E., Bräuning, B., Popova, K. D., Oakdale, N. T. S., Bonnar, J. L., Prabu, J. R., Boydston, E. A., Sevillano, N., Shurtleff, M. J., Stroud, R. M., et al. (2020) · eLife

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 86

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

Leontovyč, A., Ulrychová, L., O’Donoghue, A. J., Vondrášek, J., Marešová, L., Hubálek, M., Fajtová, P., Chanová, M., Jiang, Z., Craik, C. S., et al. (2018) · PLOS Neglected Tropical Diseases

Parasites and Host InteractionsBlood Coagulation and Thrombosis Mechanisms

Cited by 45

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Sampognaro, P. J., Arya, S., Knudsen, G. M., Gunderson, E. L., Sandoval-Perez, A., Hodul, M., Bowles, K., Craik, C. S., Jacobson, M. P., & Kao, A. W. (2023) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 35